Abstract: A stably storable and readily water soluble composition for use in preparing injections and containing Cefditoren, namely a cephalosporin of the formula ##STR1## is now provided, which composition comprises a physical mixture of Cefditoren or a non-toxic salt thereof with a proportion of arginine and/or lysine and/or a non-toxic salt thereof. This new composition of Cefditoren can be stored for long periods of time without discoloration and without undesirable reduction in the antibacterial activity, and the composition can be dissolved completely and quickly in water.

Abstract: The present invention provides a method of detecting microorganisms, comprising the step of converting physical forms of microorganisms by antigen-antibody reaction and successively measuring the information that shows the physical forms of the converted data, and the step of comparing a statistical pattern of the values thus measured and a reference statistical pattern of a control subjected to no antigen-antibody reaction, thus detecting the microorganisms of interest. A change in both patterns, i.e., no correspondence thereof, enables recognition of the presence of the microorganisms of interest.

Abstract: Novel cephalosporin derivatives having formulae (V) and (III): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.8 and A are defined as in the specification.

Abstract: A novel ester of a cephem compound having a carboxyl group at the 4-position in the nucleus; a process for preparing the same by reacting a cephem carboxylic acid or its salt with a halogenide; and a method for removing the protective group for the carboxyl group in the nucleus of a cephem compound by contacting it with an alcohol, or with an organic solvent in the presence of a Lewis acid.

Abstract: A process for preparing a cephalosporanic acid derivative or a 7-acylaminocephalosporanic acid derivative which comprises subjecting an esterifying agent to reaction in liquid sulfur dioxide in the presence of a base with an N-protected-cephalosporin C to obtain a diester, subjecting the diester to reaction in an inert solvent with an iminohalide forming agent to produce an iminohalide, subjecting the iminohalide with a lower alcohol to produce an iminoether, subjecting the product produced, after subjecting the iminoether to reaction with a reactive derivative of an organic acid, to hydrolysis and further eliminating the ester group of the carboxylic acid.

Abstract: A compound having the formula: ##EQU1## and a 7-amihocephalosporanic acid derivative having the formula: ##SPC1##Are reacted in a homogeneous aqueous solution of the reactants to prepare a reaction of the formula: ##SPC2##In the formulas, R may be H or other defined substituents such as carboxyl group; R.sub.1 is H, an alkyl of 1-4 carbons or other defined substitents; R.sub.2 is H or phenyl or when taken together with R.sub.1 form a defined cyclicradical; R.sub.3 is H or other defined substituents and M is an alkali metal cation, ammonium cation or H.