Abstract: A composition and method are disclosed for ameliorating infertility, the composition an extract of one or both of pericarp and fruit of a plant of the genus Trapa, or one or compounds isolated therefrom, as the active ingredient that is safe and has high activity, in which the one or more compounds preferably has an inhibition activity against one or more reactions involving a formation of advanced glycation end products from proteins and saccharides, an enhancing activity against one or more reactions involving a decomposition of the advanced glycation end products and an activity to reduce allergic symptoms.