Patents by Inventor Shomir Ghosh

Shomir Ghosh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CCR8 inhibitors
    Patent number: 7378525
    Abstract: Disclosed are CCR8 inhibitors represented by Structural Formulas (I): The variables in Structural Formula (I) are described herein. Also disclosed are methods of treating a subject with a CCR8 mediated condition, especially asthma, by administering one of the disclosed CCR8 inhibitors to the subject.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: May 27, 2008
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Bing Guan, Charles Minor, Mingshi Dai, Shomir Ghosh, Tracy J. Jenkins, Gang Li, Douglas F. Burdi, Robert A. Bennett
  • CCR8 inhibitors
    Patent number: 7329755
    Abstract: Disclosed is an inhibitor of CCR8 that is represented by Structural Formula (I): Also disclosed are pharmaceutical compositions comprising a pharmaceutically acceptable carrier or diluent and a CCR8 inhibitor represented by Structural Formula (I). Also disclosed is a method of treating inflammatory disorders in a subject by administering a CCR8 inhibitor to the subject.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: February 12, 2008
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Mingshi Dai, Tracy J. Jenkins, Bing Guan, Shomir Ghosh, Charles Minor
  • Chemokine receptor antagonists and methods of use thereof
    Patent number: 7271176
    Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation.
    Type: Grant
    Filed: November 13, 2002
    Date of Patent: September 18, 2007
    Assignees: Millennium Pharmaceuticals, Inc., Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C. B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
  • PGD2 receptor antagonists for the treatment of inflammatory diseases
    Patent number: 7211672
    Abstract: Disclosed herein are compounds represented by Structural Formula (I): (I), wherein the variables are defined herein. Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2 (“CRTH2”) for the treatment of inflammatory disorders.
    Type: Grant
    Filed: October 3, 2003
    Date of Patent: May 1, 2007
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Shomir Ghosh, Amy M. Elder, Kenneth G. Carson, Kevin Sprott, Sean Harrison
  • Chemokine receptor antagonists and methods of use therefor
    Publication number: 20070060592
    Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
    Type: Application
    Filed: November 10, 2006
    Publication date: March 15, 2007
    Inventors: Jay Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine Harriman, Kenneth Carson, Shomir Ghosh, Amy Elder, Karen Mattia
  • Chemokine receptor antagonists and methods of use thereof
    Patent number: 7186729
    Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation.
    Type: Grant
    Filed: November 13, 2002
    Date of Patent: March 6, 2007
    Assignees: Millennium Pharmaceuticals, Inc., Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C. B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
  • PGD2 receptor antagonists for the treatment of inflammatory diseases
    Publication number: 20060241109
    Abstract: Disclosed are CRTH2 inhibitors represented by Structural Formula (I): The values for the variables of Structural Formula (I) are provided herein.
    Type: Application
    Filed: February 23, 2006
    Publication date: October 26, 2006
    Inventors: Jeremy Little, Shomir Ghosh, Sean Harrison, Amy Elder, Christelle Renou, Kenneth Carson
  • Compounds useful as chemokine receptor antagonists
    Publication number: 20060172994
    Abstract: The present invention relates to compounds useful as Chemokine Receptor antagonists. Compounds of general formula I are provided: or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions for the inhibition of Chemokine Receptors and also for the treatment of various diseases, conditions, or disorders, including acute or chronic inflammatory disease, cancer or osteolytic bone disorders.
    Type: Application
    Filed: December 28, 2005
    Publication date: August 3, 2006
    Inventors: Kenneth Carson, Prakash Raman, Francois Soucy, Qing Ye, Shomir Ghosh
  • PGD2 receptor antagonists for the treatment of inflammatory diseases
    Publication number: 20060106061
    Abstract: Disclosed herein are compounds represented by Structural Formula (I): (I), wherein the variables are defined herein. Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2 (“CRTH2”) for the treatment of inflammatory disorders.
    Type: Application
    Filed: December 20, 2005
    Publication date: May 18, 2006
    Inventors: Shomir Ghosh, Amy Elder, Kenneth Carson, Kevin Sprott, Sean Harrison
  • PGD2 receptor antagonists for the treatment of inflammatory diseases
    Publication number: 20050256158
    Abstract: Disclosed herein are compounds represented by Structural Formula (I) and (I-A): Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2, or simply “CRTH2” for the treatment of inflammatory disorders. The variables in Structural Formula (I) and (I-A) are defined herein.
    Type: Application
    Filed: April 7, 2005
    Publication date: November 17, 2005
    Inventors: Shomir Ghosh, Amy Elder, Kenneth Carson, Kevin Sprott, Sean Harrison, Frederick Hicks, Christelle Renou, Dominic Reynolds
  • Compounds, pharmaceutical compositions and methods of use therefor
    Publication number: 20050143372
    Abstract: The invention relates to compounds having the formula (I). Preferred compounds are antagonists of C—C chemokine receptor 8. The invention also relates to a method for treating a subjected having an inflammatory disorder or viral disorder comprising administering to a subject in need thereof an effective amount of a compound of the invention.
    Type: Application
    Filed: October 30, 2002
    Publication date: June 30, 2005
    Inventors: Shomir Ghosh, Michael Patane, Kenneth Carson, I-Cheng Chi, Qing Ye, Amy Elder, Tracy Jenkins
  • Aryl sulfonamides useful as inhibitors of chemokine receptor activity
    Publication number: 20050085518
    Abstract: The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein R1, X, Z, R2, X., Ar, n, R3 and R4 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR8 and accordingly are useful for the treatment of a variety of inflammatory and allergic disorders.
    Type: Application
    Filed: July 14, 2004
    Publication date: April 21, 2005
    Inventors: Mingshi Dai, Bing Guan, Robert Bennett, Douglas Burdi, Shomir Ghosh, Gang Li, Charles Minor, Tracy Jenkins
  • Chemokine receptor antagonists and methods of use thereof
    Publication number: 20050070549
    Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt thereof.
    Type: Application
    Filed: November 13, 2002
    Publication date: March 31, 2005
    Inventors: Jay Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine Harriman, Kenneth Carson, Shomir Ghosh, Amy Elder, Karen Mattia
  • CCR8 inhibitors
    Publication number: 20040224978
    Abstract: Disclosed is an inhibitor of CCR8 that is represented by Structural Formula (I): 1
    Type: Application
    Filed: December 23, 2003
    Publication date: November 11, 2004
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Mingshi Dai, Tracy J. Jenkins, Bing Guan, Shomir Ghosh, Charles Minor
  • CCR8 Inhibitors
    Publication number: 20040209948
    Abstract: Disclosed are CCR8 inhibitors represented by Structural Formulas (I): 1
    Type: Application
    Filed: December 23, 2003
    Publication date: October 21, 2004
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Bing Guan, Charles Minor, Mingshi Dai, Shomir Ghosh, Tracy J. Jenkins, Gang Li, Douglas F. Burdi, Robert A. Bennett
  • PGD2 receptor antagonists for the treatment of inflammatory diseases
    Publication number: 20040082609
    Abstract: Disclosed herein are compounds represented by Structural Formula (I): 1
    Type: Application
    Filed: October 3, 2003
    Publication date: April 29, 2004
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Shomir Ghosh, Amy M. Elder, Kenneth G. Carson, Kevin Sprott, Sean Harrison