Patents by Inventor Shon R. Pulley

Shon R. Pulley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BORON CONTAINING PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM, METHODS AND USES THEREOF
    Publication number: 20240132525
    Abstract: The present disclosure describes boron containing pyrimidine compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the present disclosure have activity as Janus kinase (JAK) inhibitors and are useful in the in the treatment or control of inflammation, auto-immune diseases, cancer, and other disorders and indications where modulation of JAK would be desirable. Also described are methods of treating inflammation, auto-immune diseases, cancer, and other conditions that are susceptible to the inhibition of a Janus kinase by administering a compound herein described.
    Type: Application
    Filed: June 16, 2023
    Publication date: April 25, 2024
    Inventors: ALAN LONG, SHON R. PULLEY, KEITH ANDREW NEWTON GRAHAM, CHUNLIANG LIU, YASHEEN ZHOU
  • Boron containing pyrazole compounds, compositions comprising them, methods and uses thereof
    Patent number: 11827657
    Abstract: The present invention describes novel boron containing pyrazole compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the invention have activity as Janus kinase (JAK) inhibitors and are useful in the in the treatment or control of inflammation, auto-immune diseases, cancer, and other disorders and indications where modulation of JAK would be desirable. Also described are methods of treating inflammation, auto-immune diseases, cancer, and other conditions that are susceptible to the inhibition of a Janus kinase by administering a compound herein described.
    Type: Grant
    Filed: December 13, 2021
    Date of Patent: November 28, 2023
    Assignees: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC., BORAH, INC.
    Inventors: Alan Long, Chun Yu Liu, Chunliang Liu, Yasheen Zhou, Shon R. Pulley, Keith Andrew Newton Graham
  • BORON CONTAINING PYRAZOLE COMPOUNDS, COMPOSITIONS COMPRISING THEM, METHODS AND USES THEREOF
    Publication number: 20220194965
    Abstract: The present invention describes novel boron containing pyrazole compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the invention have activity as Janus kinase (JAK) inhibitors and are useful in the in the treatment or control of inflammation, auto-immune diseases, cancer, and other disorders and indications where modulation of JAK would be desirable. Also described are methods of treating inflammation, auto-immune diseases, cancer, and other conditions that are susceptible to the inhibition of a Janus kinase by administering a compound herein described.
    Type: Application
    Filed: December 13, 2021
    Publication date: June 23, 2022
    Inventors: Alan LONG, Chun Yu LIU, Chunliang LIU, Yasheen ZHOU, Shon R. PULLEY, Keith Andrew Newton GRAHAM
  • ACETYL 2-HYDROXY-1,3-DIAMINOALKANES
    Publication number: 20100145056
    Abstract: Disclosed are compounds of the formula: where variables Z, X, R15, R2, R3, and Rc are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.
    Type: Application
    Filed: November 23, 2009
    Publication date: June 10, 2010
    Inventors: Varghese John, Michel Maillard, James P. Beck, Eric T. Baldwin, Robert Hughes, Shon R. Pulley, Ruth T. TenBrink
  • Acetyl 2-hydroxy-1, 3-diaminoalkanes
    Patent number: 7645780
    Abstract: Disclosed are compounds of the formula: where variables Z, X, R15, R2, R3, and Rc are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.
    Type: Grant
    Filed: June 6, 2006
    Date of Patent: January 12, 2010
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Varghese John, Michel Maillard, James P. Beck, Eric T. Baldwin, Robert Hughes, Shon R. Pulley, Ruth T. TenBrink
  • Substituted Ureas and Carbamates
    Publication number: 20080306136
    Abstract: The invention provides compounds of formula I: useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Application
    Filed: April 1, 2008
    Publication date: December 11, 2008
    Inventors: Shon R. Pulley, John A. Tucker
  • Macrocycles useful in the treatment of alzheimer's disease
    Patent number: 7456163
    Abstract: The present invention is macrocycles of the formula (X): for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme for the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: August 19, 2005
    Date of Patent: November 25, 2008
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Shon R. Pulley, James P. Beck, Ruth E. TenBrink, Jon S. Jacobs
  • Macrocycles useful in the treatment of alzheimer's disease
    Patent number: 7442691
    Abstract: The present invention are macrocycles of the formula (IX): for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: September 2, 2005
    Date of Patent: October 28, 2008
    Assignee: Pharmacia & Upjohn Company
    Inventors: Shon R. Pulley, James P. Beck, Ruth E. TenBrink
  • Substituted ureas and carbamates
    Patent number: 7351738
    Abstract: The invention provides compounds of formula I: useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: April 1, 2008
    Assignees: Elan Pharmaceuticals, Inc., Pharmacia & Upjohn Company
    Inventors: Shon R. Pulley, John A. Tucker
  • 3,4-disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines
    Patent number: 7338965
    Abstract: The invention relates to substituted piperidine, piperazine, morpholine and thiomorpholine compounds useful in the treatment of Alzheimer's disease and more specifically to compounds that are capable of inhibiting beta-secretase, an enzyme that cleaves amyloid precursor protein to produce amyloid beta peptide (A-beta), a major component of the amyloid plaques found in the brains of Alzheimer's sufferers. One embodiment of the invention relates to compounds having the structure: where Z is CR or N, and R1, R2 and R3 are as described in the specification.
    Type: Grant
    Filed: November 19, 2002
    Date of Patent: March 4, 2008
    Assignees: Pharmacia & Upjohn Company, Elan Pharmaceuticals, Inc.
    Inventors: Joseph B. Moon, Shon R. Pulley, Daniel H. Rich, David L. Brown, Barbara Jagodzinska, Varghese John, John Jacobs
  • Hydroxypropyl amides for the treatment of Alzheimer's disease
    Patent number: 7262208
    Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: April 30, 2003
    Date of Patent: August 28, 2007
    Assignees: Elan Pharmaceuticals, Inc., Pharmacia & Upjohn Company
    Inventors: John A. Tucker, Brian A. Sherer, Ying Zi Xu, Louis Brogley, Shon R. Pulley, Jon S. Jacobs, James P. Beck, Varghese John
  • Acetyl 2-hydroxy-1, 3-diaminoalkanes
    Patent number: 7244725
    Abstract: Disclosed are compounds of the formula: where variables Z, X, R15, R2, R3, and RC are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.
    Type: Grant
    Filed: September 10, 2003
    Date of Patent: July 17, 2007
    Assignees: Elan Pharmaceuticals, Inc., Pharmacia & Upjohn Company
    Inventors: Varghese John, Michel Maillard, James P. Beck, Eric T. Baldwin, Robert Hughes, Shon R. Pulley, Ruth TenBrink
  • Compounds to treat Alzheimer's disease
    Patent number: 7214715
    Abstract: The present invention is substituted amines of formula (X) and of the formula (X?) useful in treating Alzheimer's disease and other similar diseases.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: May 8, 2007
    Assignees: Pharmacia & Upjohn, Elan Pharmaceuticals
    Inventors: James P. Beck, Lawrence Y. Fang, John N. Freskos, Andrea Gailunas, Roy Hom, Barbara Jagodzinska, Varghese John, Michel Maillard, Shon R. Pulley, Ruth E. TenBrink
  • Macrocycles useful in the treatment of Alzheimer's disease
    Patent number: 7067507
    Abstract: The present invention is macrocycles of the formula (X): for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme for the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: June 13, 2002
    Date of Patent: June 27, 2006
    Assignee: Pharmacia & Upjohn Company
    Inventors: Shon R. Pulley, James P. Beck, Ruth E. TenBrink, Jon S. Jacobs
  • Macrocycles useful in the treatment of Alzheimer's disease
    Patent number: 6969709
    Abstract: The present invention are macrocycles of the formula (IX): for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: November 29, 2005
    Assignee: Pharmacia & Upjohn Company
    Inventors: Shon R. Pulley, James P. Beck, Ruth E. TenBrink
  • Substituted ureas and carbamates
    Publication number: 20040209925
    Abstract: The invention provides compounds of formula I: 1
    Type: Application
    Filed: November 26, 2003
    Publication date: October 21, 2004
    Applicants: ELAN PHARMACEUTICALS, INC., PHARMACIA & UPJOHN COMPANY
    Inventors: Shon R. Pulley, John A. Tucker
  • Acetyl 2-hydroxy-1, 3-diaminoalkanes
    Publication number: 20040180939
    Abstract: Disclosed are compounds of the formula: 1
    Type: Application
    Filed: September 10, 2003
    Publication date: September 16, 2004
    Inventors: Varghese John, Michel Maillard, James P. Beck, Eric T. Baldwin, Robert Hughes, Shon R. Pulley, Ruth TenBrink
  • Hydroxypropyl amides for the treatment of Alzheimer's disease
    Publication number: 20040039034
    Abstract: The present invention relates to compounds of formula (I): 1
    Type: Application
    Filed: April 30, 2003
    Publication date: February 26, 2004
    Inventors: John A. Tucker, Brian A. Sherer, Ying Zi Xu, Louis Brogley, Shon R. Pulley, Jon S. Jacobs, James P. Beck, Varghese John
  • 3,4-Disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines
    Publication number: 20040034031
    Abstract: The invention relates to substituted piperidine, piperazine, morpholine and thiomorpholine compounds useful in the treatment of Alzheimer's disease and more specifically to compounds that are capable of inhibiting beta-secretase, an enzyme that cleaves amyloid precursor protein to produce amyloid beta peptide (A-beta), a major component of the amyloid plaques found in the brains of Alzheimer's sufferers.
    Type: Application
    Filed: November 19, 2002
    Publication date: February 19, 2004
    Inventors: Joseph B. Moon, Shon R. Pulley, Daniel H. Rich, David L. Brown, Barbara Jagodzinska, Varghese John, John Jacobs
  • Mycrocycles useful in the teatment of Alzheimer's disease
    Publication number: 20030236199
    Abstract: The present invention are macrocycles of the formula (IX): 1
    Type: Application
    Filed: June 12, 2002
    Publication date: December 25, 2003
    Inventors: Shon R. Pulley, James P. Beck, Ruth E. TenBrink