Patents by Inventor Shoshana Bascomb

Shoshana Bascomb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6043048
    Abstract: In an assay for determination of beta-lactam antibiotic resistance in a target bacterial strain, the strain is grown in the presence of both a beta-lactamese inducing antibiotic and a beta-lactam indicator antibiotic [which kills or inhibits the growth of bacteria] unable to hydrolyze beta-lactam antibiotics. Growth, indicative of drug resistance in the target strain, is monitored by detecting a fluorophor released by the enzymatic cleavage of a metabolizable fluorogenic compound.
    Type: Grant
    Filed: July 26, 1996
    Date of Patent: March 28, 2000
    Assignee: Dade MicroScan Inc.
    Inventors: Judith Johnston, Tracy Felland, Shoshana Bascomb, James H. Godsey
  • Patent number: 5565328
    Abstract: The present invention relates to a method to determine the concentration of an unknown substance in a colorimetric reaction using a fluorometric reader. The change in color can be monitored by observing the change of fluorescence of a known amount of a suitable fluorophore in the reaction chamber. Under appropriate conditions the absorption spectrum of the chromophore overlaps with the emission spectrum of the fluorophore thereby allowing the change in fluorescence to be proportional to the intensity of color in the reaction and thus, proportional to the quantity of the substance of interest. Specifically, 8-methoxypyrene tri-sulfonic acid is used as the fluorophore.
    Type: Grant
    Filed: December 27, 1995
    Date of Patent: October 15, 1996
    Assignee: Dade International Inc.
    Inventors: Shoshana Bascomb, Frank J. Swenson, Ted Sand
  • Patent number: 5457030
    Abstract: This invention relates to a method to determine susceptibility to antimicrobial agents of a majority of clinically significant Gram positive organisms. This invention also relates to a mixture of fluorogenic substrates used to detect the growth of Gram positive bacteria.
    Type: Grant
    Filed: September 29, 1993
    Date of Patent: October 10, 1995
    Assignee: MicroScan, Inc.
    Inventors: Robert Badal, Roger Kelley, Theodore T. Sand, Shoshana Bascomb
  • Patent number: 5372784
    Abstract: A multi-layer blood culture sensor includes two matrices. The first matrix is a polymer that is permeable to carbon dioxide and water, but impermeable to protons. A pH sensitive absorbance based dye is encapsulated or isolated in the polymer. The second matrix is a polymer with a pH insensitive fluorescent dye encapsulated or isolated in the polymer. The matrices are spectrally coupled and are useful for the determination of microorganisms in a blood culture bottle.
    Type: Grant
    Filed: March 11, 1994
    Date of Patent: December 13, 1994
    Assignee: Baxter Diagnostics Inc.
    Inventors: Roger J. Morris, Shoshana Bascomb, Carolyn S. Olson, Jamie Bobolis, David Sherman
  • Patent number: 5173434
    Abstract: A process to determine the concentration of any substance in a colorimetric, turbidimetric or nephelometric reaction using a fluorometric detector to measure fluorescence intensity. In particular, a change in color can be monitored by observing the measurement of fluorescence intensity of a fluorophore in an inert matrix. The absorption spectrum of the chromophore may overlap the excitation and/or emission spectrum of the fluorophore, thereby allowing the change in fluorescence to be related to the intensity of color in the reaction and thus related to the quantity of the substance of interest.
    Type: Grant
    Filed: November 5, 1990
    Date of Patent: December 22, 1992
    Assignee: Baxter Diagnostics Inc.
    Inventors: Roger J. Morris, Shoshana Bascomb, Carolyn S. Olson
  • Patent number: 4603108
    Abstract: A method for identifying specific bacterial species in derived samples is based on 26 tests for the presence of constitutive enzymes, which, with the exception of two tests which require about two and a half hours, can be done relatively quickly, and without need for bacterial growth. By quantifying the amount of enzyme identified by the substrate test, a highly reliable identification of bacterial species present can be made. A kit, comprising substrates specific to the enzymes to be tested for, is provided for carrying out the test.
    Type: Grant
    Filed: November 8, 1982
    Date of Patent: July 29, 1986
    Assignee: National Research Development Corp.
    Inventor: Shoshana Bascomb