Patents by Inventor Shouping Liu
Shouping Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11912650Abstract: A bakuchiol derivative, a pharmaceutically acceptable salt thereof, and a preparation method and use of the same. The bakuchiol derivative has a structure shown in formula (I): The above series of amphiphilic antibacterial compounds based on bakuchiol have comparatively excellent antibacterial activities and can overcome the generation of drug resistance of bacteria in drug resistance research simulated in a laboratory.Type: GrantFiled: October 30, 2020Date of Patent: February 27, 2024Assignee: JIANGXI SHIMEI PHARMACEUTICAL CO., LTDInventors: Shuimu Lin, Shouping Liu, Hongxia Li, Hong Jiang
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Publication number: 20230391717Abstract: A bakuchiol derivative, a pharmaceutically acceptable salt thereof, and a preparation method and use of the same. The bakuchiol derivative has a structure shown in formula (I): The above series of amphiphilic antibacterial compounds based on bakuchiol have comparatively excellent antibacterial activities and can overcome the generation of drug resistance of bacteria in drug resistance research simulated in a laboratory.Type: ApplicationFiled: October 30, 2020Publication date: December 7, 2023Applicant: JIANGXI SHIMEI PHARMACEUTICAL CO., LTD.Inventors: Shuimu LIN, Shouping LIU, Hongxia LI, Hong JIANG
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Publication number: 20190002429Abstract: The present invention relates to xanthone analogs. Such compounds may be used in the treatment of bacterial infections.Type: ApplicationFiled: March 23, 2018Publication date: January 3, 2019Inventors: Hanxun Zou, Lakshminarayanan Rajamani, Lei Zhou, Chang Chui Charles Tang, Jun Jie Koh, Tiang Hwee Donald Tan, Chandra Verma, Roger W. Beuerman, Shouping Liu, Saraswathi Padmanabhan
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Publication number: 20180193209Abstract: The present invention provides a polymer product and a method for preparing the polymer product comprising electrospinning from a dope solution comprising at least one polymer and at least one cross-linking agent to prepare and/or fabricate the polymer product. In certain embodiments, the cross-linking agent comprises at least one catecholamine or at least one polyphenol, wherein the method comprises (i) electrospinning the biocompatible polymer product using a dope solution comprising a polymer and at least one catecholamine or at least one polyphenol and (ii) exposing the polymer product to at least one gaseous alkaline reagent. The dope solutions and polymer products of the invention can further include antimicrobial agents, metal ions, and other substances.Type: ApplicationFiled: July 6, 2016Publication date: July 12, 2018Inventors: Lakshminarayanan RAJAMANI, Chetna DHAND, Seeram RAMAKRISHNA, Shouping LIU, Roger Wilmer BEUERMAN
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Patent number: 9220264Abstract: The invention relates to multimeric forms of antimicrobial peptides, for example, defensin peptides. The multimeric forms of defensin peptides possesses antimicrobial activity and may be formulated into antimicrobial compositions, pharmaceutical compositions, eyedrop composition, contact lens solution compositions for coating medical devices and the like. The invention also relates to the use of these multimeric forms of peptides, e.g. multimeric forms of defensin peptides for inhibiting and/or reducing the growth of microorganisms in general, including in a host. The invention further relates to a method of preparing multimers of peptides derived from defensins, for example hBD3. The method includes a composition or combination comprising the multimeric antimicrobial peptides and at least one active pharmaceutical ingredient.Type: GrantFiled: November 26, 2013Date of Patent: December 29, 2015Assignees: Singapore Health Services Pte Ltd., Agency for Science, Technology and ResearchInventors: Roger W. Beuerman, Shouping Liu, Jing Li, Lei Zhou, Chandra Shekhar Verma, Donald Tan
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Publication number: 20150231199Abstract: Disclosed are antimicrobial peptides. Also disclosed are methods of treating bacterial infection and fungal infection and a method of removing biofilm. Also disclosed is the use of these peptides.Type: ApplicationFiled: September 9, 2013Publication date: August 20, 2015Inventors: Verma Chandra Shekhar, Jianguo Li, Lakshminarayanan Rajamani, Roger Wilmer Beuerman, Shouping Liu, Jun Jie Koh
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Publication number: 20150225454Abstract: An isolated peptide tetramer includes the formula [(RGRKVVRR)2K]2KK and its derivatives thereof. The derivatives may include at least one amino acid substitution, at least one amino acid deletion, a rearrangement of the peptide monomer and/or at least one non-proteogenic amino acid modification in at least one peptide monomer. The isolated peptide tetramer and derivatives thereof have antimicrobial (antibacterial, antifungal and/or anti-protozoan) properties.Type: ApplicationFiled: September 9, 2013Publication date: August 13, 2015Applicants: SINGAPORE HEALTH SERVICES PTE LTD, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Roger Beuerman, Shouping Liu, Lakshminarayanan Rajamani, Chandra Verma, Jianguo Li
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Publication number: 20140349918Abstract: The present invention relates to xanthone analogs. Such compounds may be used in the treatment of bacterial infections.Type: ApplicationFiled: September 10, 2012Publication date: November 27, 2014Applicants: Singapore Health Services Pte Ltd., Agency for Science, Technology and ResearchInventors: Hanxun Zou, Lakshminiarayan Rajanmani, Lei Zhou, Chang Chui Charles Tang, Jun Jie Koh, Tiang Hwee Donald Tan, Chandra Verma, Roger W. Beuerman, Shouping Liu, Saraswathi Padmanabhan
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Patent number: 8809262Abstract: The invention relates to multimeric forms of antimicrobial peptides, for example, defensin peptides. The multimeric forms of defensin peptides possesses antimicrobial activity and may be formulated into antimicrobial compositions, pharmaceutical compositions, eyedrop composition, contact lens solution compositions for coating medical devices and the like. The invention also relates to the use of these multimeric forms of peptides, e.g. multimeric forms of defensin peptides for inhibiting and/or reducing the growth of microorganisms in general, including in a host. The invention further relates to a method of preparing multimers of peptides derived from defensins, for example hBD3.Type: GrantFiled: April 21, 2009Date of Patent: August 19, 2014Assignees: Singapore Health Service Pte Ltd., Agency for Science, Technology and ResearchInventors: Roger W. Beuerman, Shouping Liu, Jing Li, Lei Zhou, Chandra Shekhar Verma, Donald Tan
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Publication number: 20140142027Abstract: The invention relates to multimeric forms of antimicrobial peptides, for example, defensin peptides. The multimeric forms of defensin peptides possesses antimicrobial activity and may be formulated into antimicrobial compositions, pharmaceutical compositions, eyedrop composition, contact lens solution compositions for coating medical devices and the like. The invention also relates to the use of these multimeric forms of peptides, e.g. multimeric forms of defensin peptides for inhibiting and/or reducing the growth of microorganisms in general, including in a host. The invention further relates to a method of preparing multimers of peptides derived from defensins, for example hBD3. The method includes a composition or combination comprising the multimeric antimicrobial peptides and at least one active pharmaceutical ingredient.Type: ApplicationFiled: November 26, 2013Publication date: May 22, 2014Applicants: Agency for Science, Technology and Research, Singapore Health Services Pte Ltd.Inventors: Roger W. BEUERMAN, Shouping Liu, Jing Li, Lei Zhou, Chandra Shekhar Verma, Donald Tan
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Patent number: 8691945Abstract: There is provided at least one isolated antimicrobial peptide, wherein the peptide is a linear analog of hBD3 or a fragment thereof. In particular, there is provided a linear analog of hBD3 wherein the peptide has a reduced cytotoxicity to at least one cell compared to the wild type hBD3.Type: GrantFiled: April 27, 2007Date of Patent: April 8, 2014Assignees: Singapore Health Services Pte Ltd., Agency for Science, Technology and ResearchInventors: Roger Beuerman, Lei Zhou, Shouping Liu, Jing Li, Anita Suresh, Chandra Shekhar Verma, Donald Tan
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Patent number: 8080428Abstract: The present invention relates to diagnosis and/or treatment of medical conditions. The present invention relates to new method of diagnosing dry mucosa condition in a subject. The condition may be dry eye. The present invention also provides a method to monitor the efficacy of a treatment of a dry mucosa condition, a method of treating a dry mucosa condition and/or a diagnostic kit for a dry mucosa condition.Type: GrantFiled: April 26, 2007Date of Patent: December 20, 2011Assignees: Singapore Health Services Pte Ltd., Agency for Science, Technology and ResearchInventors: Roger Beuerman, Lei Zhou, Shouping Liu, He Yang, Donald Tan
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Publication number: 20110039760Abstract: The invention relates to multimeric forms of antimicrobial peptides, for example, defensin peptides. The multimeric forms of defensin peptides possesses antimicrobial activity and may be formulated into antimicrobial compositions, pharmaceutical compositions, eyedrop composition, contact lens solution compositions for coating medical devices and the like. The invention also relates to the use of these multimeric forms of peptides, e.g. multimeric forms of defensin peptides for inhibiting and/or reducing the growth of microorganisms in general, including in a host. The invention further relates to a method of preparing multimers of peptides derived from defensins, for example hBD3.Type: ApplicationFiled: April 21, 2009Publication date: February 17, 2011Applicant: SINGAPORE HEALTH SERVICES PTE LTDInventors: Roger W. Beuerman, Shouping Liu, Jing Li, Lei Zhou, Chandra Shekhar Verma, Donald Tan
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Publication number: 20100048469Abstract: There is provided at least one isolated antimicrobial peptide, wherein the peptide is a linear analog of hBD3 or a fragment thereof. In particular, there is provided a linear analog of hBD3 wherein the peptide has a reduced cytotoxicity to at least one cell compared to the wild type hBD3.Type: ApplicationFiled: April 27, 2007Publication date: February 25, 2010Applicants: SINGAPORE HEALTH SERVICES PTE LTD., AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Roger Beuerman, Lei Zhou, Shouping Liu, Jing Li, Anita Suresh, Chandra Shekhar Verma, Donald Tan
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Publication number: 20090258828Abstract: The present invention relates to diagnosis and/or treatment of medical conditions. The present invention relates to new method of diagnosing dry mucosa condition in a subject. The condition may be dry eye. The present invention also provides a method to monitor the efficacy of a treatment of a dry mucosa condition, a method of treating a dry mucosa condition and/or a diagnostic kit for a dry mucosa condition.Type: ApplicationFiled: April 26, 2007Publication date: October 15, 2009Applicants: SINGAPORE HEALTH SERVICES PTE LTD., AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Roger Beuerman, Lei Zhou, Shouping Liu, He Yang, Donald Tan