Abstract: A compound as shown in general formula (I) or stereoisomers, deuterated compounds, solvates, prodrugs, metabolites, pharmaceutically acceptable salts or co-crystals thereof, and intermediates thereof, a preparation method therefor, and a use thereof for treating BTK-related diseases, such as cancer or autoimmune diseases.

Abstract: Substituted piperidines as BTK inhibitors, a preparation method thereof and a pharmaceutical application thereof. The substituted piperidines is a compound represented by a general formula (I) or a stereoisomer or a pharmaceutically acceptable salt thereof, and the substituted piperidines is used to treat BTK-related diseases such as tumors or autoimmune system diseases.

Abstract: Provided herein are a quinolinone compound, pharmaceutical composition thereof, and use of the compound or the pharmaceutical composition in drug preparation, the drug being used to prevent, manage, treat or relieve diseases related to HIF and/or EPO of a patient, including anemia, vascular disease, myocardial ischemia, dysmetabolism, or for wound healing.

Abstract: Provided herein are a quinolinone compound, pharmaceutical composition thereof, and use of the compound or the pharmaceutical composition in drug preparation, the drug being used to prevent, manage, treat or relieve diseases related to HIF and/or EPO of a patient, including anemia, vascular disease, myocardial ischemia, dysmetabolism, or for wound healing.

Abstract: The boost turn-up method comprises a belt drum, which is carried and driven by a belt drum case, and a forming drum, which is carried and driven by a forming drum case; a first boost device, which is arranged along the axial direction, is arranged at the side part of the belt drum; a second boost device, which is arranged along the axial direction, is arranged at the side part of the forming drum; the first boost device and the second boost device are symmetrical along the vertical center line of the forming drum in the turn-up preparation process of a tire blank; the first boost device and the second boost device push the Bladder or the turn-up rods towards the center from two sides of the forming drum. Thus, the same thrust is simultaneously exerted to assist implementation of the turn-up operation.

Abstract: A bead ring and a belt-tread component are prepared in advance, and a forming drum capable of axially moving carries a tire body component to enter a forming pressing workstation. The forming machine comprises a main machine and a servicer, wherein a belt drum laminating workstation at one side of a belt drum, a main servicer laminating workstation at one side of the forming drum, and a forming pressing workstation at one side of a combined roller are arranged along the center line of a main shaft of the main machine; the prepared belt-cap ply-tread component and sidewall-inner liner-carcass ply component are conveyed to the workstations and combined with the bead ring, so as to carry out turn-up forming and pressing operation technologies of a tire blank; the forming pressing workstation is arranged between the belt drum laminating workstation and the forming pressing workstation.