Abstract: A pet toothbrush includes a hybrid brush head populated by both stiffer plastic bristles and softer TPE bristles, a brush handle and a connecting neck connecting the brush head and the brush handle. A toothpaste tube accommodates pet toothpaste. A toothpaste outlet is provided in the vicinity of the brush head. The connecting neck is provided with a toothpaste channel connected with the toothpaste outlet. The connection between the connecting neck and the brush handle is provided with a one-way delivery valve of toothpaste from the toothpaste tube to the toothpaste channel and then extruded from the toothpaste outlet. The toothbrush can continuously squeeze the toothpaste by way of a push cap or button to ensure the cleaning effect. The toothbrush has replaceable brush heads. The toothpaste outlet can be closed to maintain toothbrush cleanliness.