Abstract: Although compounds for treating or ameliorating malignant diseases have been proposed, patients had to endure a large burden since many of such compounds could not be orally ingested. Mangiferin has an effect of ameliorating malignant diseases through oral ingestion. However, such effect is minor and realistically it was not easy to ingest mangiferin. Further, in order to develop more effective pharmaceutical agents and the like for treating malignant diseases, it has been considered constantly necessary to obtain new or improved forms of an existing medical agent for inhibiting kinases such as NIK. Compounds represented by formula (1), formula (2), formula (3), formula (4), formula (5), formula (6), formula (7), formula (8), formula (9), formula (10), formula (11), and formula (12) have an effect of ameliorating malignant diseases through oral ingestion, and can exhibit said effect with an amount less than that for mangiferin.

Abstract: [Problem] COVID-19 caused by coronavirus SARS-CoV-2, cytokine release syndrome, cytokine release syndrome with CAR (chimeric antigen receptor)-T therapy, sepsis, systemic inflammatory response syndrome, hemophagocytic syndrome, macrophage activation syndrome, influenza, GVHD, systemic vasculitis, Kawasaki disease, Takayasu arteritis, and other diseases, if severe, can cause acute respiratory distress syndrome, disseminated intravascular coagulation syndrome, acute circulatory insufficiency, multi-organ failure, and other symptoms which are one of the causes of death. [Solution to Problem] Compounds represented by formulas (1) to (4) are effective when taken orally and can be expressed in smaller amounts than mangiferin.

Abstract: There are no drugs or food medicines that can prevent or ameliorate, among side effects caused by drugs, particularly peripheral neuropathy that is caused by anticancer drugs such as oxaliplatin. An agent for preventing or ameliorating peripheral neuropathy including at least one selected from xylitol, L-talitol, and D-threitol as an active ingredient can ameliorate tingling limbs, limb pain, decreased deep tendon reflexes, muscle weakness, allodynia, hyperalgesia, hand fine motor skill disability, gait disturbance, stumbling, falling, flexion impairment (difficulty or inability to sit on one's knees, cross-legged, sideways, in a chair, etc.), limb paralysis, or the like, induced by drugs such as anticancer drugs or diabetes.

Abstract: No drug has been available for treating a peripheral sensory neuropathy caused as a side effect by a drug, in particular, by an anticancer drug such as oxaliplatin. A composition for ameliorating peripheral sensory neuropathy, which is characterized by including a Lentinus edodes mycelium extract, ameliorates symptoms induced by the drug such as the anticancer drug, including numbness of extremities, a pain in extremities, a reduction in deep tendon reflection, a reduction in muscle force, allodynia, hyperalgesia, impaired finger fine movement, impaired walking, stumbling, falling, impaired flexion (being difficult or impossible to sit on one's heels, sit cross-legged, sit with one's legs out to one side, sit on a chair, or the like), or paralysis of extremities.

Abstract: No drug has been available for treating a peripheral sensory neuropathy caused as a side effect by a drug, in particular, by an anticancer drug such as oxaliplatin. A composition for ameliorating peripheral sensory neuropathy, which is characterized by including a Lentinus edodes mycelium extract, ameliorates symptoms induced by the drug such as the anticancer drug, including numbness of extremities, a pain in extremities, a reduction in deep tendon reflection, a reduction in muscle force, allodynia, hyperalgesia, impaired finger fine movement, impaired walking, stumbling, falling, impaired flexion (being difficult or impossible to sit on one's heels, sit cross-legged, sit with one's legs out to one side, sit on a chair, or the like), or paralysis of extremities.

Abstract: No drug has been available for treating a peripheral sensory neuropathy caused as a side effect by a drug, in particular, by an anticancer drug such as oxaliplatin. A composition for ameliorating peripheral sensory neuropathy, which is characterized by including a Lentinus edodes mycelium extract, ameliorates symptoms induced by the drug such as the anticancer drug, including numbness of extremities, a pain in extremities, a reduction in deep tendon reflection, a reduction in muscle force, allodynia, hyperalgesia, impaired finger fine movement, impaired walking, stumbling, falling, impaired flexion (being difficult or impossible to sit on one's heels, sit cross-legged, sit with one's legs out to one side, sit on a chair, or the like), or paralysis of extremities.

Abstract: Provided is an exposure-preventing cap of a novel and simple structure that, by being mounted on a vial, can more reliably inhibit leaking of drug solution to an outside when pulling out and collecting drug solution in a syringe from the vial. An exposure-preventing cap, which is mounted on a mouth of a vial sealed with a rubber stopper, wherein a puncturing hole is formed in a center part of a cap-shaped housing that is attached to a mouth of the vial, and a rubber membrane is arranged at the puncturing hole so as to form an internal space between facing surfaces of the rubber membrane and the rubber stopper. The rubber membrane has a dome shape that is convex facing the rubber stopper.

Abstract: Provided is an exposure-preventing cap of a novel and simple structure that, by being mounted on a vial, can more reliably inhibit leaking of drug solution to an outside when pulling out and collecting drug solution in a syringe from the vial. An exposure-preventing cap, which is mounted on a mouth of a vial sealed with a rubber stopper, wherein a puncturing hole is formed in a center part of a cap-shaped housing that is attached to a mouth of the vial, and a rubber membrane is arranged at the puncturing hole so as to form an internal space between facing surfaces of the rubber membrane and the rubber stopper. The rubber membrane has a dome shape that is convex facing the rubber stopper.

Abstract: A plug for a container capable of improving air-tightness and liquid-tightness is provided. A plug includes a first split piece having a cylindrical first fitting portion to be mounted on an opening portion of a container body and fitted to an opening portion space of the opening portion, an end wall which blocks one end of the first fitting portion, and a first flange portion extending outwardly in a radial direction of the first fitting portion from the other end thereof; and a second split piece having a second fitting portion which is fitted to the first fitting portion of the first split piece and forms a closed space between the end wall and the second fitting portion and a second flange portion extending outwardly in a radial direction of the second fitting portion therefrom.

Abstract: A plug for a container capable of improving air-tightness and liquid-tightness is provided. A plug includes a first split piece having a cylindrical first fitting portion to be mounted on an opening portion of a container body and fitted to an opening portion space of the opening portion, an end wall which blocks one end of the first fitting portion, and a first flange portion extending outwardly in a radial direction of the first fitting portion from the other end thereof; and a second split piece having a second fitting portion which is fitted to the first fitting portion of the first split piece and forms a closed space between the end wall and the second fitting portion and a second flange portion extending outwardly in a radial direction of the second fitting portion therefrom.

Abstract: An apparatus for mixing a fluid feed stock, such as a heavy oil, and particles of a catalyst for gasifying the heavy oil in a reactor, comprises the reactor having in the upper portion a circular port through which the particles are fed, a moving bed-forming section disposed on and in communication with the reactor for forming the particles into an annular or cylindrical high-velocity moving bed by dropping the particles downwardly into the reactor, while dispersing the particles radially, an external fluid feed section located so as to spray the feed stock over the entire upper outer periphery of the annular or cylindrical moving bed passing through the reactor, and an internal fluid-feed section located so as to spray the fluid over the entire upper inner periphery corresponding to the outer periphery of the annular moving bed.

Abstract: An apparatus for mixing a fluid feed stock, such as a heavy oil, and particles of a catalyst for gasifying the heavy oil in a reactor, comprises the reactor having in the upper portion a circular port through which the particles are fed, a moving bed-forming section disposed on and in communication with the reactor for forming the particles into an annular or cylindrical high-velocity moving bed by dropping the particles downwardly into the reactor, while dispersing the particles radially, an external fluid feed section located so as to spray the feed stock over the entire upper outer periphery of the annular or cylindrical moving bed passing through the reactor, and an internal fluid-feed section located so as to spray the fluid over the entire upper inner periphery corresponding to the outer periphery of the annular moving bed.

Abstract: An apparatus for mixing a fluid feed stock, such as a heavy oil, and particles of a catalyst for gasifying the heavy oil in a reactor, comprises the reactor having in the upper portion a circular port through which the particles are fed, a moving bed-forming section disposed on and in communication with the reactor for forming the particles into an annular or cylindrical high-velocity moving bed by dropping the particles downwardly into the reactor, while dispersing the particles radially, an external fluid feed section located so as to spray the feed stock over the entire upper outer periphery of the annular or cylindrical moving bed passing through the reactor, and an internal fluid-feed section located so as to spray the fluid over the entire upper inner periphery corresponding to the outer periphery of the annular moving bed.

Abstract: A method for manufacturing hollow parts using a mold assembly including a movable mold having a male die and a female die for shaping two split halves, respectively, of the hollow part and being mounted on a movable platen and a sliding mold capable of movement between two positions within a horizontally moving sliding mold guide and having a female die and a male die that face the male die and the female die, respectively, the method comprises the steps of: injecting a molten resin into a pair of cavities formed between the opposing male die and female die and between the opposing male die and female die through a primary sprue in the sliding mold, thereby forming split halves; separating the movable mold from a fixed mold together with the sliding mold guide so that a resin sprue runner portion that has solidified within the primary sprue is knocked out of the mold assembly and then sliding the mold so that the split halves left within the respective female dies will face each other; bringing the movable an

Abstract: A coated paper prepared by coating an original paper with a paper-coating composition is provided containing a pigment and a copolymer latex having a gel content of 10% by weight or more obtained by polymerizing,(a) 20-65% by weight of a conjugated diene compound,(b) 0.1 to 10% by weight of an ethylenically unsaturated carboxylic acid, and(c) 33-79.5% by weight of at least one ethylenically unsaturated compound other than said components (a) and (b),(d) in the presence of 0.1 to 10 parts by weight of .alpha.-methylstyrene dimer, per 100 parts by weight of a total of components (a), (b) and (c).

Abstract: A process is provided for producing a copolymer latex having a gel content of 10-98% by weight, involving emulsion polymerizing:(a) 20-65% by weight of a conjugated diene compound;(b) 0.1-10% by weight of a combination of an ethylenically unsaturated monocarboxylic acid with an ethylenically unsaturated dicarboxylic acid; and(c) 33-79.5% by weight of at least one ethylenically unsaturated compound other than the components (a) and (b),in the presence of (d) 0.1 to 10 parts by weight of an .alpha.-methylstyrene dimer, per 100 parts by weight of a total of components (a), (b) and (c).

Abstract: A two-stage process for producing a copolymer, comprising emulsion polymerizing (a) a 2-80% by weight of a conjugated diene compound, (b) 0.1-10% by weight of an ethylenically unsaturated carboxylic acid, and (c) 10-97.9% by weight of an ethylenically unsaturated compound other than the components (a) and (b) in the presence of (d) and .alpha.-methylstyrene dimer, wherein in the first stage, 10-50% by weight of the total amount of the components (a), (b) and (c) are added and polymerized at 70.degree.-80.degree. C. for 2-6 hours after the addition of the monomer, and after said first stage, 50-90% by weight of the total amount of the components (a), (b) and (c) are continuously fed and polymerized in a second stage.

Abstract: Liquid mobility is judged by the steps of filling the specimen in a specimen chamber formed in a specimen bed made of a transparent material just up to the level of the upper surface of the specimen bed, of pressing a liquid-absorbent material keeper for keeping a liquid-absorbent material horizontally to make the liquid-absorbent material contact with the specimen bed from the upper side of the specimen chamber, and of continuously detecting an intensity of a scattered light coming from the specimen in the specimen chamber with an optical detector consisting of a light emitting source and a light receiver and being disposed on the side of the lower surface of the specimen bed while the liquid-absorbent material is forced to contact the specimen bed. The liquid mobility is grasped in a short period of time.