Patents by Inventor Shozo Takagi

Shozo Takagi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6491900
    Abstract: Candies and confectioneries containing non-toxic sparingly soluble calcium and phosphate compounds as additives, cause the release of calcium and phosphate ions into the oral cavity gradually and persistently for a period no less than five minutes. Released calcium phosphate ions diffuse into partially demineralized tooth enamel or dentin, leasing to remineralization and repair of caries lesions, dental plaque, open dentinal tubules and exposed dentin. Agents and methods for remineralization of teeth, for reducing or eradicating cariogenic challenge in plaque following sucrose intake for producing effective anticaries actions without the use of fluoride and for desensitizing hypersensitive teeth are disclosed.
    Type: Grant
    Filed: January 26, 2001
    Date of Patent: December 10, 2002
    Assignee: American Dental Association Health Foundation
    Inventors: Laurence C. Chow, Shozo Takagi, Gerald L. Vogel
  • Publication number: 20020137812
    Abstract: A bone or dental implant material in the form of a paste includes a mixture of calcium phosphate powders, that are capable of forming hydroxyapatite, with liquid glycerol and hydroxypropyl methylcellulose and Na2HPO4. The paste will harden upon exposure to water with the time to harden controlled by the choice and ratio of constituents.
    Type: Application
    Filed: January 23, 2002
    Publication date: September 26, 2002
    Applicant: American Dental Association Health Foundation
    Inventors: Laurence C. Chow, Shozo Takagi
  • Patent number: 6398859
    Abstract: A pulp-capping and base/lining cement comprising the combination of paste 1 and either paste 2 or a powder, wherein paste 1 contains a carboxylated monomer, dicalcium phophate, and water; and paste 2 or the powder contains a polymerizable base monomer and tetracalcium phosphate. The cement is useful in the repair and/or restoration of dental lesions as well as repair and/or restoration of other calcium and calcium phosphorus containing parts of living organisms.
    Type: Grant
    Filed: December 23, 1999
    Date of Patent: June 4, 2002
    Assignee: American Dental Association Health Foundation
    Inventors: Sabine H. Dickens, Shozo Takagi
  • Patent number: 6325992
    Abstract: Calcium phosphate compositions that are particularly useful and unique as orthopedic and dental cements and remineralizers, as well as methods and kits for their use, and the resulting products are disclosed. The compositions comprise tetracalcium phosphate which has been prepared from a mixture with a calcium to phosphorous ratio of less than 2, or prepared and maintained under substantially anhydrous conditions prior to use or, preferably, both. The novel compositions are converted substantially to hydroxyapatite upon setting, are substantially gradually resorbable and replaced by bone when implanted in contact with living bony tissue, and offer distinct advantages in terms of cement strength, setting time and reliability and other properties.
    Type: Grant
    Filed: February 28, 2000
    Date of Patent: December 4, 2001
    Assignee: American Dental Association Health Foundation
    Inventors: Laurence C. Chow, Shozo Takagi
  • Publication number: 20010033831
    Abstract: Candies and confectioneries containing non-toxic sparingly soluble calcium and phosphate compounds as additives, cause the release of calcium and phosphate ions into the oral cavity gradually and persistently for a period no less than five minutes. Released calcium phosphate ions diffuse into partially demineralized tooth enamel or dentin, leasing to remineralization and repair of caries lesions, dental plaque, open dentinal tubules and exposed dentin. Agents and methods for remineralization of teeth, for reducing or eradicating cariogenic challenge in plaque following sucrose intake for producing effective anticaries actions without the use of fluoride and for desensitizing hypersensitive teeth are disclosed.
    Type: Application
    Filed: January 26, 2001
    Publication date: October 25, 2001
    Inventors: Laurence C. Chow, Shozo Takagi, Gerald L. Vogel
  • Patent number: 5997624
    Abstract: The invention includes methods and compositions relating to calcium phosphate cements, which self-harden substantially to hydroxyapatite at ambient temperature when in contact with an aqueous medium. More specifically the cements comprise a combination of one or more sparingly soluble calcium phosphates other than tetracalcium phosphate with an aqueous solution adjusted with a base to maintain a pH of about 12.5 or above and having sufficient dissolved phosphate salt to yield a solution mixture with phosphate concentration equal to or greater than about 0.2 mol/L.
    Type: Grant
    Filed: April 16, 1998
    Date of Patent: December 7, 1999
    Assignee: American Dental Association Health Foundation
    Inventors: Laurence C. Chow, Shozo Takagi
  • Patent number: 5993786
    Abstract: The invention relates to anticarious delivery vehicles, specifically chewing gums, candies, confectioneries, toothpastes, dentifrices and gels. The invention specifically provides chewing gums, candies, confectioneries, toothpastes, dentifrices and gels containing non-toxic sparingly soluble calcium and phosphate compounds as additives, causing the release of calcium and phosphate ions into the oral cavity gradually and persistently for a period no less than 5 minutes. The invention provides released calcium phosphate ions that diffuse into partially demineralized tooth enamel or dentin, leading to remineralization and repair of caries lesions, dental plaque, open dentinal tubules and exposed dentin. The invention thus provides agents and methods for remineralization of teeth and for reducing or eradicating cariogenic challenge in plaque following sucrose intake. The formulations of the invention can thereby produce effective anticaries actions without the use of fluoride.
    Type: Grant
    Filed: June 2, 1998
    Date of Patent: November 30, 1999
    Assignee: American Dental Association Health Foundation
    Inventors: Laurence C. Chow, Shozo Takagi, Gerald L. Vogel
  • Patent number: 5976234
    Abstract: The invention includes methods and compositions relating to calcium phosphate cements, which self-harden substantially to hydroxyapatite at ambient temperature when in contact with an aqueous medium. More specifically the cements comprise a combination of one or more sparingly soluble calcium phosphates other than tetracalcium phosphate with an aqueous solution adjusted with a base to maintain a pH of about 12.5 or above and having sufficient dissolved phosphate salt to yield a solution mixture with phosphate concentration equal to or greater than about 0.2 mol/L.
    Type: Grant
    Filed: April 25, 1997
    Date of Patent: November 2, 1999
    Assignee: American Dental Association Health Foundation
    Inventors: Laurence C. Chow, Shozo Takagi
  • Patent number: 5954867
    Abstract: The invention includes methods and compositions relating to calcium phosphate cements, which self-harden substantially to hydroxyapatite at ambient temperature when in contact with an aqueous medium. More specifically the cements comprise a combination of one or more sparingly soluble calcium phosphates other than tetracalcium phosphate with an aqueous solution adjusted with a base to maintain a pH of about 12.5 or above and having sufficient dissolved phosphate salt to yield a solution mixture with phosphate concentration equal to or greater than about 0.2 mol/L.
    Type: Grant
    Filed: April 25, 1997
    Date of Patent: September 21, 1999
    Assignee: American Dental Health Foundation Association
    Inventors: Laurence C. Chow, Shozo Takagi
  • Patent number: 5891448
    Abstract: Specific compositions and methods are disclosed employing calcium fluoride inhibitors in two-component fluoride delivery systems to produce an initial delay in calcium fluoride formation and to control the rate of reactions that precipitate calcium fluoride in order to achieve enhanced fluoride deposition in the oral environment. In the two-component fluoride delivery system, one component contains a source of calcium ions and the other a source of fluoride ions. An inhibitor of calcium fluoride formation is present in one or both phases such that when one or both components are mixed the formation of calcium fluoride precipitate does not occur until at least about five seconds after mixing. The system may be employed in the form of mouth rinses, dentifrices, or chewable tablets.
    Type: Grant
    Filed: October 29, 1996
    Date of Patent: April 6, 1999
    Assignee: American Dental Association Health Foundation
    Inventors: Laurence C. Chow, Shozo Takagi
  • Patent number: 5833954
    Abstract: The invention relates to anticarious delivery vehicles, specifically chewing gums, candies, confectioneries, toothpastes, dentifrices and gels. The invention specifically provides chewing gums, candies, confectioneries, toothpastes, dentifrices and gels containing non-toxic sparingly soluble calcium and phosphate compounds as additives, causing the release of calcium and phosphate ions into the oral cavity gradually and persistently for a period no less than 5 minutes. The invention provides released calcium phosphate ions that diffuse into partially demineralized tooth enamel or dentin, leading to remineralization and repair of caries lesions, dental plaque, open dentinal tubules and exposed dentin. The invention thus provides agents and methods for remineralization of teeth and for reducing or eradicating cariogenic challenge in plaque following sucrose intake. The formulations of the invention can thereby produce effective anticaries actions without the use of fluoride.
    Type: Grant
    Filed: August 20, 1996
    Date of Patent: November 10, 1998
    Assignee: American Dental Association Health Foundation
    Inventors: Laurence C. Chow, Shozo Takagi, Gerald L. Vogel
  • Patent number: 5695729
    Abstract: Calcium phosphate compositions that are particularly useful and unique as orthopedic and dental cements and remineralizers, as well as methods and kits for their use, and the resulting products are disclosed. The compositions comprise tetracalcium phosphate which has been prepared from a mixture with a calcium to phosphorous ratio of less than 2, or prepared and maintained under substantially anhydrous conditions prior to use or, preferably, both. The novel compositions are converted substantially to hydroxyapatite upon setting, are substantially gradually resorbable and replaced by bone when implanted in contact with living bony tissue, and offer distinct advantages in terms of cement strength, setting time and reliability and other properties.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 9, 1997
    Assignee: American Dental Association Health Foundation
    Inventors: Laurence C. Chow, Shozo Takagi
  • Patent number: 5545254
    Abstract: Calcium phosphate compositions that are particularly useful and unique as orthopedic and dental cements and remineralizers, as well as methods and kits for their use, and the resulting products are disclosed. The compositions comprise tetracalcium phosphate which has been prepared from a mixture with a calcium to phosphorous ratio of less than 2, or prepared and maintained under substantially anhydrous conditions prior to use or, preferably, both. The novel compositions are converted substantially to hydroxyapatite upon setting, are substantially gradually resorbable and replaced by bone when implanted in contact with living bony tissue, and offer distinct advantages in terms of cement strength, setting time and reliability and other properties.
    Type: Grant
    Filed: December 9, 1994
    Date of Patent: August 13, 1996
    Assignee: The American Dental Association Health Foundation
    Inventors: Laurence C. Chow, Shozo Takagi
  • Patent number: 5542973
    Abstract: Calcium phosphate compositions that are particularly useful and unique as orthopedic and dental cements and remineralizers, as well as methods and kits for their use, and the resulting products are disclosed. The compositions comprise tetracalcium phosphate which has been prepared from a mixture with a calcium to phosphorous ratio of less than 2, or prepared and maintained under substantially anhydrous conditions prior to use or, preferably, both. The novel compositions are converted substantially to hydroxyapatite upon setting, are substantially gradually resorbable and replaced by bone when implanted in contact with living bony tissue, and offer distinct advantages in terms of cement strength, setting time and reliability and other properties.
    Type: Grant
    Filed: December 9, 1994
    Date of Patent: August 6, 1996
    Assignee: The American Dental Association Health Foundation
    Inventors: Laurence C. Chow, Shozo Takagi
  • Patent number: 5525148
    Abstract: The invention includes methods and compositions relating to calcium phosphate cements, which self-harden substantially to hydroxyapatite at ambient temperature when in contact with an aqueous medium. More specifically the cements comprise a combination of one or more sparingly soluble calcium phosphates other than tetracalcium phosphate with an aqueous solution adjusted with a base to maintain a pH of about 12.5 or above and having sufficient dissolved phosphate salt to yield a solution mixture with phosphate concentration equal to or greater than about 0.2 mol/L.
    Type: Grant
    Filed: September 24, 1993
    Date of Patent: June 11, 1996
    Assignee: American Dental Association Health Foundation
    Inventors: Laurence C. Chow, Shozo Takagi
  • Patent number: 5522893
    Abstract: Calcium phosphate compositions that are particularly useful and unique as orthopedic and dental cements and remineralizers, as well as methods and kits for their use, and the resulting products are disclosed. The compositions comprise tetracalcium phosphate which has been prepared from a mixture with a calcium to phosphorous ratio of less than 2, or prepared and maintained under substantially anhydrous conditions prior to use or, preferably, both. The novel compositions are converted substantially to hydroxyapatite upon setting, are substantially gradually resorbable and replaced by bone when implanted in contact with living bony tissue, and offer distinct advantages in terms of cement strength, setting time and reliability and other properties.
    Type: Grant
    Filed: March 12, 1993
    Date of Patent: June 4, 1996
    Assignee: American Dental Association Health Foundation
    Inventors: Laurence C. Chow, Shozo Takagi
  • Patent number: 5476647
    Abstract: The present invention relates to compositions and methods for fluoridating teeth. More specifically, the invention is a reactive, multi-component composition consisting of an admixture of a stable, non-toxic soluble calcium salt and a soluble calcium complexing (chelating) agent, with a stable, non-toxic soluble fluoride compound, a buffer, and one or more non-interfering carriers. The components of this admixture are mixed in an aqueous environment, resulting in a controlled precipitation of calcium fluoride, and then promptly applied to the tooth surfaces. The invention contemplates mouth rinses, dentifrices, gels, and chewable tablets for application of these compositions and methods.
    Type: Grant
    Filed: September 13, 1993
    Date of Patent: December 19, 1995
    Assignee: American Dental Association Health Foundation
    Inventors: Laurence C. Chow, Shozo Takagi
  • Patent number: 5145668
    Abstract: Previous mouthwashes and dentifrices containing fluoride contributed relatively modest amounts of additional fluoride to the tooth surfaces, and scavenged calcium from the teeth. The present invention can deposit significantly more fluoride in the mouth than previously used formulations containing comparable amounts of fluoride, without scavenging calcium from the teeth. The invention includes a method of fluoridating teeth comprising (1) mixing in an aqueous environment a first component comprising a stable, non-toxic soluble calcium salt with a second component comprising a stable, non-toxic readily hydrolyzable complex fluoride compound, resulting in hydrolysis of the fluoride compound and precipitation of calcium fluoride, followed by (2) prompt application of the mixture to tooth surfaces. The invention also contemplates mouth rinses, denifrices, gels or pastes, and chewable tablets for application of the above-described compositions.
    Type: Grant
    Filed: December 21, 1990
    Date of Patent: September 8, 1992
    Assignee: American Dental Association Health Foundation
    Inventors: Laurence C. Chow, Shozo Takagi
  • Patent number: 4553795
    Abstract: A method and arrangement for setting metal molds on a press bolster are disclosed. A plurality of spaced bearing units are arranged in a press bolster wherein freely rotatable main large balls of the bearing units protrude at their tops slightly above a level of an upper surface of the bolster so as to cooperate to freely slidably support a combined set of an upper and a lower molds placed thereon, for positional adjustment of the molds to a desired exact position on the bolster.
    Type: Grant
    Filed: March 30, 1984
    Date of Patent: November 19, 1985
    Inventor: Shozo Takagi
  • Patent number: 4459909
    Abstract: A method and arrangement for setting metal molds on a press bolster are disclosed. A plurality of spaced bearing units are arranged in a press bolster wherein freely rotatable main large balls of the bearing units protrude at their tops slightly above a level of an upper surface of the bolster so as to cooperate to freely slidably support a combined set of an upper and a lower molds placed thereon, for positional adjustment of the molds to a desired exact position on the bolster.
    Type: Grant
    Filed: April 2, 1982
    Date of Patent: July 17, 1984
    Inventor: Shozo Takagi