Patents by Inventor Shozo Takagi
Shozo Takagi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6491900Abstract: Candies and confectioneries containing non-toxic sparingly soluble calcium and phosphate compounds as additives, cause the release of calcium and phosphate ions into the oral cavity gradually and persistently for a period no less than five minutes. Released calcium phosphate ions diffuse into partially demineralized tooth enamel or dentin, leasing to remineralization and repair of caries lesions, dental plaque, open dentinal tubules and exposed dentin. Agents and methods for remineralization of teeth, for reducing or eradicating cariogenic challenge in plaque following sucrose intake for producing effective anticaries actions without the use of fluoride and for desensitizing hypersensitive teeth are disclosed.Type: GrantFiled: January 26, 2001Date of Patent: December 10, 2002Assignee: American Dental Association Health FoundationInventors: Laurence C. Chow, Shozo Takagi, Gerald L. Vogel
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Publication number: 20020137812Abstract: A bone or dental implant material in the form of a paste includes a mixture of calcium phosphate powders, that are capable of forming hydroxyapatite, with liquid glycerol and hydroxypropyl methylcellulose and Na2HPO4. The paste will harden upon exposure to water with the time to harden controlled by the choice and ratio of constituents.Type: ApplicationFiled: January 23, 2002Publication date: September 26, 2002Applicant: American Dental Association Health FoundationInventors: Laurence C. Chow, Shozo Takagi
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Patent number: 6398859Abstract: A pulp-capping and base/lining cement comprising the combination of paste 1 and either paste 2 or a powder, wherein paste 1 contains a carboxylated monomer, dicalcium phophate, and water; and paste 2 or the powder contains a polymerizable base monomer and tetracalcium phosphate. The cement is useful in the repair and/or restoration of dental lesions as well as repair and/or restoration of other calcium and calcium phosphorus containing parts of living organisms.Type: GrantFiled: December 23, 1999Date of Patent: June 4, 2002Assignee: American Dental Association Health FoundationInventors: Sabine H. Dickens, Shozo Takagi
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Patent number: 6325992Abstract: Calcium phosphate compositions that are particularly useful and unique as orthopedic and dental cements and remineralizers, as well as methods and kits for their use, and the resulting products are disclosed. The compositions comprise tetracalcium phosphate which has been prepared from a mixture with a calcium to phosphorous ratio of less than 2, or prepared and maintained under substantially anhydrous conditions prior to use or, preferably, both. The novel compositions are converted substantially to hydroxyapatite upon setting, are substantially gradually resorbable and replaced by bone when implanted in contact with living bony tissue, and offer distinct advantages in terms of cement strength, setting time and reliability and other properties.Type: GrantFiled: February 28, 2000Date of Patent: December 4, 2001Assignee: American Dental Association Health FoundationInventors: Laurence C. Chow, Shozo Takagi
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Publication number: 20010033831Abstract: Candies and confectioneries containing non-toxic sparingly soluble calcium and phosphate compounds as additives, cause the release of calcium and phosphate ions into the oral cavity gradually and persistently for a period no less than five minutes. Released calcium phosphate ions diffuse into partially demineralized tooth enamel or dentin, leasing to remineralization and repair of caries lesions, dental plaque, open dentinal tubules and exposed dentin. Agents and methods for remineralization of teeth, for reducing or eradicating cariogenic challenge in plaque following sucrose intake for producing effective anticaries actions without the use of fluoride and for desensitizing hypersensitive teeth are disclosed.Type: ApplicationFiled: January 26, 2001Publication date: October 25, 2001Inventors: Laurence C. Chow, Shozo Takagi, Gerald L. Vogel
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Patent number: 5997624Abstract: The invention includes methods and compositions relating to calcium phosphate cements, which self-harden substantially to hydroxyapatite at ambient temperature when in contact with an aqueous medium. More specifically the cements comprise a combination of one or more sparingly soluble calcium phosphates other than tetracalcium phosphate with an aqueous solution adjusted with a base to maintain a pH of about 12.5 or above and having sufficient dissolved phosphate salt to yield a solution mixture with phosphate concentration equal to or greater than about 0.2 mol/L.Type: GrantFiled: April 16, 1998Date of Patent: December 7, 1999Assignee: American Dental Association Health FoundationInventors: Laurence C. Chow, Shozo Takagi
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Patent number: 5993786Abstract: The invention relates to anticarious delivery vehicles, specifically chewing gums, candies, confectioneries, toothpastes, dentifrices and gels. The invention specifically provides chewing gums, candies, confectioneries, toothpastes, dentifrices and gels containing non-toxic sparingly soluble calcium and phosphate compounds as additives, causing the release of calcium and phosphate ions into the oral cavity gradually and persistently for a period no less than 5 minutes. The invention provides released calcium phosphate ions that diffuse into partially demineralized tooth enamel or dentin, leading to remineralization and repair of caries lesions, dental plaque, open dentinal tubules and exposed dentin. The invention thus provides agents and methods for remineralization of teeth and for reducing or eradicating cariogenic challenge in plaque following sucrose intake. The formulations of the invention can thereby produce effective anticaries actions without the use of fluoride.Type: GrantFiled: June 2, 1998Date of Patent: November 30, 1999Assignee: American Dental Association Health FoundationInventors: Laurence C. Chow, Shozo Takagi, Gerald L. Vogel
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Patent number: 5976234Abstract: The invention includes methods and compositions relating to calcium phosphate cements, which self-harden substantially to hydroxyapatite at ambient temperature when in contact with an aqueous medium. More specifically the cements comprise a combination of one or more sparingly soluble calcium phosphates other than tetracalcium phosphate with an aqueous solution adjusted with a base to maintain a pH of about 12.5 or above and having sufficient dissolved phosphate salt to yield a solution mixture with phosphate concentration equal to or greater than about 0.2 mol/L.Type: GrantFiled: April 25, 1997Date of Patent: November 2, 1999Assignee: American Dental Association Health FoundationInventors: Laurence C. Chow, Shozo Takagi
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Patent number: 5954867Abstract: The invention includes methods and compositions relating to calcium phosphate cements, which self-harden substantially to hydroxyapatite at ambient temperature when in contact with an aqueous medium. More specifically the cements comprise a combination of one or more sparingly soluble calcium phosphates other than tetracalcium phosphate with an aqueous solution adjusted with a base to maintain a pH of about 12.5 or above and having sufficient dissolved phosphate salt to yield a solution mixture with phosphate concentration equal to or greater than about 0.2 mol/L.Type: GrantFiled: April 25, 1997Date of Patent: September 21, 1999Assignee: American Dental Health Foundation AssociationInventors: Laurence C. Chow, Shozo Takagi
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Patent number: 5891448Abstract: Specific compositions and methods are disclosed employing calcium fluoride inhibitors in two-component fluoride delivery systems to produce an initial delay in calcium fluoride formation and to control the rate of reactions that precipitate calcium fluoride in order to achieve enhanced fluoride deposition in the oral environment. In the two-component fluoride delivery system, one component contains a source of calcium ions and the other a source of fluoride ions. An inhibitor of calcium fluoride formation is present in one or both phases such that when one or both components are mixed the formation of calcium fluoride precipitate does not occur until at least about five seconds after mixing. The system may be employed in the form of mouth rinses, dentifrices, or chewable tablets.Type: GrantFiled: October 29, 1996Date of Patent: April 6, 1999Assignee: American Dental Association Health FoundationInventors: Laurence C. Chow, Shozo Takagi
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Patent number: 5833954Abstract: The invention relates to anticarious delivery vehicles, specifically chewing gums, candies, confectioneries, toothpastes, dentifrices and gels. The invention specifically provides chewing gums, candies, confectioneries, toothpastes, dentifrices and gels containing non-toxic sparingly soluble calcium and phosphate compounds as additives, causing the release of calcium and phosphate ions into the oral cavity gradually and persistently for a period no less than 5 minutes. The invention provides released calcium phosphate ions that diffuse into partially demineralized tooth enamel or dentin, leading to remineralization and repair of caries lesions, dental plaque, open dentinal tubules and exposed dentin. The invention thus provides agents and methods for remineralization of teeth and for reducing or eradicating cariogenic challenge in plaque following sucrose intake. The formulations of the invention can thereby produce effective anticaries actions without the use of fluoride.Type: GrantFiled: August 20, 1996Date of Patent: November 10, 1998Assignee: American Dental Association Health FoundationInventors: Laurence C. Chow, Shozo Takagi, Gerald L. Vogel
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Patent number: 5695729Abstract: Calcium phosphate compositions that are particularly useful and unique as orthopedic and dental cements and remineralizers, as well as methods and kits for their use, and the resulting products are disclosed. The compositions comprise tetracalcium phosphate which has been prepared from a mixture with a calcium to phosphorous ratio of less than 2, or prepared and maintained under substantially anhydrous conditions prior to use or, preferably, both. The novel compositions are converted substantially to hydroxyapatite upon setting, are substantially gradually resorbable and replaced by bone when implanted in contact with living bony tissue, and offer distinct advantages in terms of cement strength, setting time and reliability and other properties.Type: GrantFiled: June 7, 1995Date of Patent: December 9, 1997Assignee: American Dental Association Health FoundationInventors: Laurence C. Chow, Shozo Takagi
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Patent number: 5545254Abstract: Calcium phosphate compositions that are particularly useful and unique as orthopedic and dental cements and remineralizers, as well as methods and kits for their use, and the resulting products are disclosed. The compositions comprise tetracalcium phosphate which has been prepared from a mixture with a calcium to phosphorous ratio of less than 2, or prepared and maintained under substantially anhydrous conditions prior to use or, preferably, both. The novel compositions are converted substantially to hydroxyapatite upon setting, are substantially gradually resorbable and replaced by bone when implanted in contact with living bony tissue, and offer distinct advantages in terms of cement strength, setting time and reliability and other properties.Type: GrantFiled: December 9, 1994Date of Patent: August 13, 1996Assignee: The American Dental Association Health FoundationInventors: Laurence C. Chow, Shozo Takagi
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Patent number: 5542973Abstract: Calcium phosphate compositions that are particularly useful and unique as orthopedic and dental cements and remineralizers, as well as methods and kits for their use, and the resulting products are disclosed. The compositions comprise tetracalcium phosphate which has been prepared from a mixture with a calcium to phosphorous ratio of less than 2, or prepared and maintained under substantially anhydrous conditions prior to use or, preferably, both. The novel compositions are converted substantially to hydroxyapatite upon setting, are substantially gradually resorbable and replaced by bone when implanted in contact with living bony tissue, and offer distinct advantages in terms of cement strength, setting time and reliability and other properties.Type: GrantFiled: December 9, 1994Date of Patent: August 6, 1996Assignee: The American Dental Association Health FoundationInventors: Laurence C. Chow, Shozo Takagi
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Patent number: 5525148Abstract: The invention includes methods and compositions relating to calcium phosphate cements, which self-harden substantially to hydroxyapatite at ambient temperature when in contact with an aqueous medium. More specifically the cements comprise a combination of one or more sparingly soluble calcium phosphates other than tetracalcium phosphate with an aqueous solution adjusted with a base to maintain a pH of about 12.5 or above and having sufficient dissolved phosphate salt to yield a solution mixture with phosphate concentration equal to or greater than about 0.2 mol/L.Type: GrantFiled: September 24, 1993Date of Patent: June 11, 1996Assignee: American Dental Association Health FoundationInventors: Laurence C. Chow, Shozo Takagi
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Patent number: 5522893Abstract: Calcium phosphate compositions that are particularly useful and unique as orthopedic and dental cements and remineralizers, as well as methods and kits for their use, and the resulting products are disclosed. The compositions comprise tetracalcium phosphate which has been prepared from a mixture with a calcium to phosphorous ratio of less than 2, or prepared and maintained under substantially anhydrous conditions prior to use or, preferably, both. The novel compositions are converted substantially to hydroxyapatite upon setting, are substantially gradually resorbable and replaced by bone when implanted in contact with living bony tissue, and offer distinct advantages in terms of cement strength, setting time and reliability and other properties.Type: GrantFiled: March 12, 1993Date of Patent: June 4, 1996Assignee: American Dental Association Health FoundationInventors: Laurence C. Chow, Shozo Takagi
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Patent number: 5476647Abstract: The present invention relates to compositions and methods for fluoridating teeth. More specifically, the invention is a reactive, multi-component composition consisting of an admixture of a stable, non-toxic soluble calcium salt and a soluble calcium complexing (chelating) agent, with a stable, non-toxic soluble fluoride compound, a buffer, and one or more non-interfering carriers. The components of this admixture are mixed in an aqueous environment, resulting in a controlled precipitation of calcium fluoride, and then promptly applied to the tooth surfaces. The invention contemplates mouth rinses, dentifrices, gels, and chewable tablets for application of these compositions and methods.Type: GrantFiled: September 13, 1993Date of Patent: December 19, 1995Assignee: American Dental Association Health FoundationInventors: Laurence C. Chow, Shozo Takagi
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Patent number: 5145668Abstract: Previous mouthwashes and dentifrices containing fluoride contributed relatively modest amounts of additional fluoride to the tooth surfaces, and scavenged calcium from the teeth. The present invention can deposit significantly more fluoride in the mouth than previously used formulations containing comparable amounts of fluoride, without scavenging calcium from the teeth. The invention includes a method of fluoridating teeth comprising (1) mixing in an aqueous environment a first component comprising a stable, non-toxic soluble calcium salt with a second component comprising a stable, non-toxic readily hydrolyzable complex fluoride compound, resulting in hydrolysis of the fluoride compound and precipitation of calcium fluoride, followed by (2) prompt application of the mixture to tooth surfaces. The invention also contemplates mouth rinses, denifrices, gels or pastes, and chewable tablets for application of the above-described compositions.Type: GrantFiled: December 21, 1990Date of Patent: September 8, 1992Assignee: American Dental Association Health FoundationInventors: Laurence C. Chow, Shozo Takagi
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Patent number: 4553795Abstract: A method and arrangement for setting metal molds on a press bolster are disclosed. A plurality of spaced bearing units are arranged in a press bolster wherein freely rotatable main large balls of the bearing units protrude at their tops slightly above a level of an upper surface of the bolster so as to cooperate to freely slidably support a combined set of an upper and a lower molds placed thereon, for positional adjustment of the molds to a desired exact position on the bolster.Type: GrantFiled: March 30, 1984Date of Patent: November 19, 1985Inventor: Shozo Takagi
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Patent number: 4459909Abstract: A method and arrangement for setting metal molds on a press bolster are disclosed. A plurality of spaced bearing units are arranged in a press bolster wherein freely rotatable main large balls of the bearing units protrude at their tops slightly above a level of an upper surface of the bolster so as to cooperate to freely slidably support a combined set of an upper and a lower molds placed thereon, for positional adjustment of the molds to a desired exact position on the bolster.Type: GrantFiled: April 2, 1982Date of Patent: July 17, 1984Inventor: Shozo Takagi