Abstract: The invention provides a system for detection and quantification of Parkinson's disease, including a substantially planar digitizer tablet fixedly mounted on a base plate and capable of translating graphic information into digital information displayable, via a computer, as graphic information on a monitor screen viewable by the subject to be tested, and a handle to be gripped and steered by the subject. The handle is fixedly attached to, and supported by, a guide providing the handle with two degrees of freedom in translation in a plane above, and substantially parallel to, the plane of the digitizer tablet. The system further includes a stylus moving together with the handle and adapted to produce signals sensible by the digitizer tablet, and means to produce on the monitor screen a model path of a predetermined shape and size, as well as a target to be tracked by the subject, the target moving at a predetermined speed along the model path.