Abstract: An article includes a path that extends across at least a portion of a surface of the article, the path being defined by at least one channel that traverses at least a portion of the surface or a first plurality of spaced features disposed on or in at least a portion of the surface. The first plurality of spaced features are arranged in a plurality of groupings. The groupings of features comprise repeat units, where the spaced features within a grouping are spaced apart at an average distance of about 1 nanometer to about 500 micrometers to define a path that traverses the plurality of spaced features.

Abstract: Generally, an intraocular implant having on the external surface a plurality of pattern surface elements disposed in spaced apart relation defining a tortuous pathway adapted to control a flow of fluid or a flow of particles suspended in a fluid or inhibit the growth or migration of cells is provided. In particular, an intraocular implant that is implanted between an intraocular lens and the surface of the posterior capsule of the eye inhibits growth or migration of residual lens epithelial cells after cataract surgery by providing structural barriers to reduce posterior capsule opacification of the eye.

Abstract: An article has a surface topography for resisting bioadhesion of organisms and includes a base article having a surface. A composition of the surface includes a polymer. The surface has a topography comprising a pattern defined by a plurality of spaced apart features attached to or projected into the base article. The plurality of features each have at least one microscale dimension and at least one neighboring feature having a substantially different geometry, wherein neighboring patterns share a common feature. The surface has an optical transmission at 400 nm to 700 nm of equal to or greater than 70%. In one embodiment, the surface can comprise a coating layer disposed on the base article.

Abstract: Generally, an intraocular implant having on the external surface a plurality of pattern surface elements disposed in spaced apart relation defining a tortuous pathway adapted to control a flow of fluid, or a flow of particles suspended in a fluid, or inhibits the growth or migration of cells. In particular, an intraocular implant which implanted between an intraocular lens and the surface of the posterior capsule of the eye inhibits growth or migration of residual lens epithelial cells after cataract surgery by providing structural barriers to reduce posterior capsule opacification of the eye.

Abstract: Disclosed herein is a ventilator text fixture comprising a ventilator port that connects to a ventilator through a breathing circuit; where the ventilator delivers air through the ventilator port to a ventilator test fixture at a rate and pressure that can be controlled by a user to simulate inhalation; an input port; where the input port is in fluid communication with the ventilator port; where the input port permits additional simulated secretions or test liquids to be pumped into the ventilator text fixture; one or more bent supports; a liquid reservoir; where the liquid reservoir is operative to hold test fluids; and one or more tubes; where the one or more tubes are in fluid communication with the ventilator port and the input port via the liquid reservoir; and where the one or more bent supports are operative to mimic an anatomy of the trachea.

Abstract: Disclosed herein is an article including a path that extends across at least a portion of a surface of the article, the path being defined by at least one channel that traverses at least a portion of the surface or a first plurality of spaced features disposed on or in at least a portion of the surface; the spaced features arranged in a plurality of groupings; the groupings of features comprising repeat units; the spaced features within a grouping being spaced apart at an average distance of about 1 nanometer to about 500 micrometers to define a path that traverses the plurality of spaced features; each feature having a surface that is substantially parallel to a surface on a neighboring feature; each feature being separated from its neighboring feature; the groupings of features being arranged with respect to one another so as to define a tortuous pathway.

Abstract: Disclosed herein is an article that includes a first plurality of spaced features. The spaced features are arranged in a plurality of groupings; the groupings of features include repeat units; the spaced features within a grouping are spaced apart at an average distance of about 1 nanometer to about 500 micrometers; each feature having a surface that is substantially parallel to a surface on a neighboring feature; each feature being separated from its neighboring feature; the groupings of features being arranged with respect to one another so as to define a tortuous pathway. The plurality of spaced features provide the article with an engineered roughness index of about 5 to about 20.

Abstract: Disclosed herein is a ventilator text fixture comprising a ventilator port that connects to a ventilator through a breathing circuit; where the ventilator delivers air through the ventilator port to a ventilator test fixture at a rate and pressure that can be controlled by a user to simulate inhalation; an input port; where the input port is in fluid communication with the ventilator port; where the input port permits additional simulated secretions or test liquids to be pumped into the ventilator text fixture; one or more bent supports; a liquid reservoir; where the liquid reservoir is operative to hold test fluids; and one or more tubes; where the one or more tubes are in fluid communication with the ventilator port and the input port via the liquid reservoir; and where the one or more bent supports are operative to mimic an anatomy of the trachea.

Abstract: Generally, an intraocular implant having on the external surface a plurality of pattern surface elements disposed in spaced apart relation defining a tortuous pathway adapted to control a flow of fluid, or a flow of particles suspended in a fluid, or inhibits the growth or migration of cells. In particular, an intraocular implant which implanted between an intraocular lens and the surface of the posterior capsule of the eye inhibits growth or migration of residual lens epithelial cells after cataract surgery by providing structural barriers to reduce posterior capsule opacification of the eye.