Abstract: AUTO-INJECTOR ASSEMBLY The auto-injector assembly (100) includes a housing (102), a syringe assembly (202) to store a predetermined volume of a drug to be administered, a needle guard (212) to surround the syringe assembly (202) such that a portion of the needle guard (212) is adapted to extend out of the housing (102) in an initial state and to retract into the housing (102) when the portion is pressed on to an injection site, a spring holder (218) to hold a dose delivery spring (216) in a compressed state, locking unit (220) to keep the spring holder (218) in a locked state, and a plunger (222) engaged with the spring holder (218) and adapted to move towards the syringe assembly (202) when the spring holder (218) is unlocked. A position of engagement of the plunger 222) with the spring holder (218) is adapted to change for controlling a travelling distance of the plunger (222) within the housing (102) based on the predetermined volume of the drug in the syringe assembly (202).

Abstract: An auto-injector device for delivering medicaments is disclosed. The auto-injector device includes a syringe assembly having a needle adapted to expel medicaments from the syringe assembly and a barrel adapted to hold the medicaments. The syringe assembly includes a plunger positioned coaxially with respect to the barrel and adapted to reciprocate within the barrel to expel the medicaments from the barrel. Further, the syringe assembly includes a locking member adapted to be engaged with the plunger to hold he plunger in a position with respect to the barrel. The position of the plunger with respect to the barrel is adapted to be adjusted to vary a volume of medicaments to be expelled from the barrel. The position of the plunger is adjusted by engaging the locking member with the plunger at one of a plurality of positions along a length of the plunger.

Abstract: The present invention provides an improved method for the manufacture of Cyclosporin A is disclosed. Cyclosporin A is produced by solid state fermentation of Fusarium solani in a bioreactor under optimal fermentation parameters. The product is extracted and further purified by treating with alum and subsequent chromatographic procedures to get pharmaceutical acceptable purity.

Abstract: The present invention provides an improved method for the manufacture of Mycophenolic acid by solid substrate fermentation of Pencillium brevi-campactum, in a contained bioreactor under optimal fermentation parameters with its subsequent purification steps.