Abstract: The present invention relates to a process for preparing pharmaceutical compositions and other herbal products derived from herbs of Traditional Chinese Medicine (TCM), including Radix astragali (Milkvetch—Huang Qi), Ligusticum chuanxiong (Chuan Xiong), Radix angelicae sinensis (Chinese Angelica—Dang Gui) and Radix polygalae (Thinleaf milkwort—Yuan Zhi). The process includes a single extraction of the TCM herbs by heating in a hydro-alcoholic solvent, wherein the alcohol may be ethanol. FIG. 2 provides an overview of one embodiment of the process. The invention also relates to products of the process of the invention, and their use in the treatment of stroke and various neurological disorders.

Abstract: The present invention relates to a process for preparing pharmaceutical compositions and other herbal products derived from herbs of Traditional Chinese Medicine (TCM), including Radix astragali (Milkvetch—Huang Qi), Ligusticum chuanxiong (Chuan Xiong), Radix angelicae sinensis (Chinese Angelica—Dang Gui) and Radix polygalae (Thinleaf milkwort—Yuan Zhi). The process includes a single extraction of the TCM herbs by heating in a hydro-alcoholic solvent, wherein the alcohol may be ethanol. FIG. 2 provides an overview of one embodiment of the process. The invention also relates to products of the process of the invention, and their use in the treatment of stroke and various neurological disorders.

Abstract: This invention relates to a stable, easy to constitute, injectable formulation of anticancer agent BMY-25067. More specifically, the present invention concerns a formulation of BMY-25067 obtained from lyophilizing a solution comprising up to 4 mg of BMY-25067 per mL of 65% t-butanol/water, further comprising about 2% PVP (K-12 or K-17), optionally comprising pharmaceutically acceptable carrier(s).

Abstract: A stabilized pharmaceutical composition containing paclitaxel, teniposide, camptothecin or other antineoplastic agent susceptible to degradation during storage is produced using a solvent system containing a low carboxylate anion content. The solvent system is a mixture of ethanol and a polyoxyethylated castor oil. The polyoxyethylated castor oil is treated with an acid or contacted with alumina to reduce the carboxylate anion content of the solvent. The low carboxylate anion content of the solvent provides extended shelf life and lower amounts of degradation by-products.

Abstract: A stable solution of mitomycin C in propylene glycol or propylene glycol/water is disclosed. The solutions have an acceptable shelf-life of greater than 24 months at 4.degree. C. and can be injected directly or diluted with water or other aqueous parenteral vehicle for parenteral administration.

Abstract: A solution of etoposide in dimethylisosorbide is disclosed. The solution is useful for filling gelatin capsules and may also be formulated into parenteral dosage forms.

Abstract: Stable, injectable, aqueous solutions of 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-[(substituted)alkoxy]benzamid e antiemetic agents are prepared by adding, as stabilizing agent, a pharmaceutically acceptable, water-miscible, hydroxylic organic solvent or water-soluble polyhydric alcohol or sugar which decreases the polarity of the solution.