Patents by Inventor Shreesti Shrestha

Shreesti Shrestha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS OF TREATMENT OF MUSCLE DISORDERS BY TARGETING H19X-ENCODED NON-CODING RNAS
    Publication number: 20230304007
    Abstract: Provided here are compositions and methods of preventing or treating a muscle disorder in a subject, such as muscle wasting, cachexia, sarcopenia and heart failure. The compositions include inhibitors targeting one or more of the H19X-encoded non-coding RNAs. The inhibitors can inhibit expression of one or more of the H19X-encoded non-coding RNAs or inhibit interaction between one or more of the H19X-encoded non-coding RNAs and their natural target mRNA. Also, provided are methods of preventing or treating a muscle disorder in a subject by inducing specific mutations to decrease levels of one or more of the H19X-encoded non-coding RNAs utilizing gene editing tools such as, but not limited to, integrases, CRISPR/Cas nucleases, TALAN nucleases, zinc finger Nucleases, triplex forming oligonucleotides, or combinations thereof.
    Type: Application
    Filed: March 26, 2023
    Publication date: September 28, 2023
    Inventors: Yu Liu, Robert J. Schwartz, Xiaopeng Shen, Rui Liang, Shreesti Shrestha