Patents by Inventor SHRIKANTA CHATTOPADHYAY

SHRIKANTA CHATTOPADHYAY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ALDH3A2 INHIBITION AND FERROPTOSIS INDUCTION FOR CANCER THERAPY
    Publication number: 20230000896
    Abstract: Disclosed herein are methods and compositions for inhibiting Aldh3a2 expression and activity to improve leukemia outcomes. Aldh3a2 depletion results in iron-dependent oxidative cell death of leukemia cells while sparing normal hematopoiesis.
    Type: Application
    Filed: December 9, 2020
    Publication date: January 5, 2023
    Inventors: David T. Scadden, Rushdia Yusuf, Nick Van Gastel, Azeem S. Sharda, Borja Saez, Shrikanta Chattopadhyay, Vasanthi S. Viswanathan
  • Compositions and methods for treating multiple myeloma
    Patent number: 10851051
    Abstract: In one aspect, the present invention provides a method of inhibiting proliferation of a multiple myeloma cell, the method comprising contacting the cell with BRD9647, thereby inhibiting proliferation of the cell. In another aspect, the present invention provides a method of treating multiple myeloma in a pre-selected subject, the method comprising administering an effective amount of BRD9647 to the subject, wherein the subject is pre-selected by detecting a mutation in an AZIN1 polynucleotide or polypeptide relative to a reference in a biological sample obtained from the subject. In another aspect, the present invention provides a method of modulating benzoylation of an agent in a cell, the method comprising contacting the cell with BRD9647, thereby modulating benzoylation of an agent in the cell.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: December 1, 2020
    Assignees: THE BROAD INSTITUTE, INC., THE GENERAL HOSPITAL CORPORATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Shrikanta Chattopadhyay, Stuart L. Schreiber, Zarko Boskovic
  • COMPOUNDS AND METHODS FOR INCREASING TUMOR INFILTRATION BY IMMUNE CELLS
    Publication number: 20190008961
    Abstract: Provided herein are compounds, compositions, and methods that increase the infiltration of tumor cell microenvironments by immune cells. Such methods are useful for enhancing a subject's immune response against the tumor.
    Type: Application
    Filed: January 6, 2017
    Publication date: January 10, 2019
    Applicants: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE GENERAL HOSPITAL CORPORATION
    Inventors: SHRIKANTA CHATTOPADHYAY, STUART L. SCHREIBER
  • COMPOSITIONS AND METHODS FOR TREATING MULTIPLE MYELOMA
    Publication number: 20190010120
    Abstract: In one aspect, the present invention provides a method of inhibiting proliferation of a multiple myeloma cell, the method comprising contacting the cell with BRD9647, thereby inhibiting proliferation of the cell. In another aspect, the present invention provides a method of treating multiple myeloma in a pre-selected subject, the method comprising administering an effective amount of BRD9647 to the subject, wherein the subject is pre-selected by detecting a mutation in an AZIN1 polynucleotide or polypeptide relative to a reference in a biological sample obtained from the subject. In another aspect, the present invention provides a method of modulating benzoylation of an agent in a cell, the method comprising contacting the cell with BRD9647, thereby modulating benzoylation of an agent in the cell.
    Type: Application
    Filed: August 12, 2016
    Publication date: January 10, 2019
    Applicants: THE BROAD INSTITUTE, INC., THE GENERAL HOSPITAL CORPORATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: SHRIKANTA CHATTOPADHYAY, STUART L. SCHREIBER, ZARKO BOSKOVIC