Patents by Inventor Shrikumar Nair

Shrikumar Nair has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for delivery of growth factor to fibrous connective tissue
    Patent number: 8067021
    Abstract: The presently disclosed subject matter relates to a peptide composition for non-covalently localizing fibrous connective tissue-inducing growth factor to a surface of an implant, the composition comprising a peptide having binding affinity for a surface material of an implant coupled to a peptide having binding affinity for a fibrous connective tissue-inducing growth factor. Methods are provided for delivering fibrous connective tissue-inducing growth factor GDF-7 in an amount effective to promote fibrous connective tissue repair and fibrous connective tissue formation. Also provided are methods of applying the peptide composition to an implant by contacting the composition with a surface of the implant; and kits comprising the compositions.
    Type: Grant
    Filed: September 4, 2008
    Date of Patent: November 29, 2011
    Assignee: Affinergy, Inc.
    Inventors: Benjamin Marcus Buehrer, Paul Hamilton, Dalia Juzumiene, Shrikumar Nair, Yuchen Chen
  • Fibrin targeted therapeutics
    Publication number: 20070111947
    Abstract: Fibrin targeted therapeutic agents for the treatment of thromboembolism, infection, and cancer are provided.
    Type: Application
    Filed: October 16, 2006
    Publication date: May 17, 2007
    Inventors: Thomas McMurry, Andrew Kolodziej, Alan Carpenter, Simon Jones, Philip Graham, Richard Looby, Shrikumar Nair, Xifang Wang, Kirsten Overoye-Chan, John Barrett
  • Peptide-based multimeric targeted contrast agents
    Patent number: 6991775
    Abstract: Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: January 31, 2006
    Assignee: Epix Medical, Inc.
    Inventors: Steffi K. Koerner, Andrew Kolodziej, Thomas J. McMurry, Shrikumar Nair, Alexander L. Nivorozhkin, Wei-Chuan Sun, Xifang Wang
  • Binding moieties for fibrin
    Publication number: 20050261472
    Abstract: The present invention provides binding moieties for fibrin, which have a variety of uses wherever detecting, isolating or localizing fibrin, and particularly fibrin as opposed to fibrinogen, is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding fibrin and recognizing the form of polymerized fibrin found in thrombi. Such polypeptides and disclosed derivatives are useful, e.g., as imaging agents for thrombi. Preferred embodiments useful as magnetic resonance imaging (MRI) contrast agents useful for detecting a thrombus in vivo are also disclosed.
    Type: Application
    Filed: August 26, 2003
    Publication date: November 24, 2005
    Inventors: Charles Wescott, James Beltzer, Shrikumar Nair, Andrew Kolodziej
  • Targeting multimeric imaging agents through multilocus binding
    Publication number: 20040005274
    Abstract: The present invention relates to contrast agents for diagnostic imaging. In particular, this invention relates to novel multimeric compounds which exhibit improved relaxivity properties upon binding to endogenous proteins or other physiologically relevant sites.
    Type: Application
    Filed: May 27, 2003
    Publication date: January 8, 2004
    Applicant: Epix Medical, Inc., a Delaware corporation
    Inventors: Randall B. Lauffer, Thomas J. McMurry, Stephane Dumas, Andrew Kolodziej, John C. Amedio, Peter D. Caravan, Zhaoda Zhang, Shrikumar Nair, Robert M. Weisskoff
  • Peptide-based multimeric targeted contrast agents
    Publication number: 20030216320
    Abstract: Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
    Type: Application
    Filed: July 30, 2002
    Publication date: November 20, 2003
    Inventors: Steffi K. Koerner, Andrew Kolodziej, Thomas J. McMurry, Shrikumar Nair, Alexander L. Nivorozhkin, Wei-Chuan Sun, Xifang Wang
  • Peptides peptide analogs peptidomimetics and other small molecules useful for inhibiting the activity of ribonucleotide reductase
    Patent number: 6030942
    Abstract: The invention relates to compositions which are useful for inhibiting ribonucleotide reductase enzymes, including the mammalian ribonucleotide reductase enzyme. The compositions include, but are not limited to, linear peptides, cyclic peptides, peptide analogs, and peptidomimetics. Methods of using the compositions of the invention to treat cancer and viral and bacterial infections are disclosed.
    Type: Grant
    Filed: March 17, 1998
    Date of Patent: February 29, 2000
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Barry S. Cooperman, Ralph F. Hirschmann, Amos B. Smith, III, Paul Laub, Setsuya Sasho, Paul A. Sprengeler, Bari A. Barwis, Alison Fisher, Shrikumar Nair