Abstract: An integrated autonomous operation system that holistically renders the operation in digital form at multiple scales, including reservoir, surface infrastructure, workflows, processes, and the real asset. The system provides an end-to-end digital twin connecting subsurface to production. A subsurface model identifies and monitors water-producing zones for strategic decisions. The models use intelligent AI to provide optimum water injection setpoints. The models provide data to systems that automatically control the chokes and valves to meet the setpoints, thus achieving fully integrated, autonomous operations.