Abstract: The present invention relates to compounds as defined herein, which are activators of long form cyclic nucleotide phosphodiesterase-4 (PDE4) enzymes (isoforms) and to therapies using these activators. In particular, the invention relates to these activator compounds for use in a method for the treatment or prevention of disorders requiring a reduction of second messenger responses mediated by cyclic 3?,5?-adenosine monophosphate (cAMP).

Abstract: A computing device may identify a plurality of equally sized data blocks of a first navigation file and may identify a plurality of equally sized data blocks of a second navigation file. The computing device may perform binary difference operations between the data blocks of the first navigation file to corresponding data blocks of the second navigation file The result of the binary difference operations is stored in a plurality of navigation patch files. At least two of the plurality of navigation patch files are merged into a merged navigation patch file.

Abstract: The present invention relates to compounds as defined herein, which are activators of long form cyclic nucleotide phosphodiesterase-4 (PDE4) enzymes (isoforms) and to therapies using these activators. In particular, the invention relates to these activator compounds for use in a method for the treatment or prevention of disorders requiring a reduction of second messenger responses mediated by cyclic 3?,5?-adenosine monophosphate (cAMP).

Abstract: A method for controlling a trajectory of an ego vehicle (EV) comprises a step of obtaining map data describing connectivity of lanes at an intersection, a step of obtaining first turn probabilities for each connection of lanes at the, and a step of planning a trajectory of the ego vehicle (EV) at the intersection in accordance with the first turn probabilities.

Abstract: Methods, systems, and apparatuses are described for throttling and management of notifications. A rules manager stores definitions of multiple classes of notifications for sending to recipients. Each of the classes has a respective set of throttling parameters that enables notifications in each class to be selectively throttled. A notification monitor monitors the number of notifications in each class transmitted to a plurality of recipients over time. In response to determining that a threshold number of notifications of a class have been transmitted to a recipient during an interval of time, the recipient is placed in a throttled mode for the class that reduces a subsequent number of notifications transmitted to the recipient. The threshold number may be dependent upon a transmission channel of the notification. The recipient is informed of being placed in the throttled mode and provided an indication of where subsequent notifications can be accessed.

Abstract: Methods, systems, and apparatuses are described for throttling and management of notifications. A rules manager stores definitions of multiple classes of notifications for sending to recipients. Each of the classes has a respective set of throttling parameters that enables notifications in each class to be selectively throttled. A notification monitor monitors the number of notifications in each class transmitted to a plurality of recipients over time. In response to determining that a threshold number of notifications of a class have been transmitted to a recipient during an interval of time, the recipient is placed in a throttled mode for the class that reduces a subsequent number of notifications transmitted to the recipient. The threshold number may be dependent upon a transmission channel of the notification. The recipient is informed of being placed in the throttled mode and provided an indication of where subsequent notifications can be accessed.

Abstract: A computing device may identify a plurality of equally sized data blocks of a first navigation file and may identify a plurality of equally sized data blocks of a second navigation file. The computing device may perform binary difference operations between the data blocks of the first navigation file to corresponding data blocks of the second navigation file The result of the binary difference operations is stored in a plurality of navigation patch files. At least two of the plurality of navigation patch files are merged into a merged navigation patch file.