Patents by Inventor Shriram Raghavan

Shriram Raghavan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11898183
    Abstract: The present disclosure discloses a recombinant microbe producing podophyllotoxin, or its derivatives, comprising genes encoding phenyl alanine ammonia-lyase (PAL), cinnamate-4-hydroxylate (C4H), 4-coumaroyl CoA-ligase (4CL), hydroxycinnamoyl-CoA quinate hydroxycinnamoyltransferase (HCT), p-coumaroyl quinate 3?-hydroxylase (C3H), caffeoyl CoA O-methyltransferase (CCoAOMT), bifunctional pinoresinol-lariciresinol reductase (DIRPLR), secoisolariciresinol dehydrogenase (SDH), cytochrome P450 oxidoreductase CYP719, O-methyltransferase (OMT), cytochrome P450 oxidoreductase CYP71, and 2-oxoglutarate/Fe(II)-dependent dioxygenase (2-ODD). Also disclosed herein is a method for producing podophyllotoxin or its derivatives. Moreover, a method of treating cancer is also disclosed.
    Type: Grant
    Filed: June 10, 2021
    Date of Patent: February 13, 2024
    Inventors: Panchapagesa Muthuswamy Murali, Arumbuliyur Sathish Kumar, Shriram Raghavan
  • Publication number: 20220033867
    Abstract: The present disclosure discloses a recombinant microbe producing podophyllotoxin, or its derivatives, comprising genes encoding phenyl alanine ammonia-lyase (PAL), cinnamate-4-hydroxylate (C4H), 4-coumaroyl CoA-ligase (4CL), hydroxycinnamoyl-CoA quinate hydroxycinnamoyltransferase (HCT), p-coumaroyl quinate 3?-hydroxylase (C3H), caffeoyl CoA O-methyltransferase (CCoAOMT), bifunctional pineresionl-lariciresinol reductase (DIRPLR), secoisolariciresinol dehydrogenase (SDH), cytochrome P450 oxidoreductase CYP719, O-methyltransferase (OMT), cytochrome P450 oxidoreductase CYP71, and 2-oxoglutarate/Fe(II)-dependent dioxygenase (2-ODD). Also disclosed herein is a method for producing podophyllotoxin or its derivatives. Moreover, a method of treating cancer is also disclosed.
    Type: Application
    Filed: June 10, 2021
    Publication date: February 3, 2022
    Inventors: Panchapagesa Muthuswamy MURALI, Arumbuliyur Sathish KUMAR, Shriram RAGHAVAN
  • Publication number: 20170306376
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express a zeaxanthin cleavage dioxygenase alone or in combination with recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce compounds from saffron such as crocetin, crocetin dialdehyde, crocin, or picrocrocin.
    Type: Application
    Filed: May 8, 2017
    Publication date: October 26, 2017
    Inventors: Shriram Raghavan, Jorgen Hansen, Shailendra Sonkar, Sathish Kumar, Kalyan Kumar, Murali Panchapagesa, Esben Hansen, Klavs Riishede Hansen
  • Publication number: 20140248668
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express a zeaxanthin cleavage dioxygenase alone or in combination with recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce compounds from saffron such as crocetin, crocetin dialdehyde, crocin, or picrocrocin.
    Type: Application
    Filed: August 7, 2012
    Publication date: September 4, 2014
    Applicant: EVOLVA SA
    Inventors: Shriram Raghavan, Jorgen Hansen, Shailendra Sonkar, Sathish Kumar, Murali Panchapagesa, Esben Halkjaer Hansen, Klavs Riishede Hansen, Kalyan Kumar