Abstract: A system for acquiring an electrical signal comprises: a plurality of electrodes, a plurality of signal quality detectors, each detector, being configured to detect a signal from a pair of electrodes and each detector comprising an analog-to-digital converter for providing a digital representation of a first resolution of the detected signal; a signal selection logic for determining at least one quality measure of each of the digital representations for selecting a pair of electrodes for signal acquisition; a multiplexer for selecting a pair of electrodes for signal acquisition based on a control signal from the signal selection logic; and a signal processing unit for performing analog-to-digital conversion on the selected signal and providing a digital representation having a second resolution, which is higher than the first resolution.