Patents by Inventor Shu-Chuan Lin
Shu-Chuan Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220186312Abstract: A method for identifying a potential biomarker for determining the probability of the success of embryo implantation by assaying a methylation profile of cervical secretions.Type: ApplicationFiled: December 10, 2021Publication date: June 16, 2022Applicant: Guzip Biomarkers CorporationInventors: Hung-Cheng Lai, Rui-Lan Huang, Shu-Chuan Lin
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Patent number: 8999688Abstract: A polysaccharide-protein binding model of SBD, and a fibril-forming 14-residue peptide consisting of X1NNNX2X3NYQX4X5X6X7X8, wherein the X1 and X8 mean a pair of opposite charged amino acid residues, and the X2, X3, X4, X5, X6, or X7 means an amino acid residue is described. A mixture for diminishing a polysaccharide, comprising at least two starch binding domains (SBDs) and a polysaccharide in a helix form is also presented. A method of providing an oligosaccharide, and a method of producing an amyloid-like fibril and use thereof are further described.Type: GrantFiled: January 19, 2011Date of Patent: April 7, 2015Assignee: National Tsing Hua UniversityInventors: Margaret Dah-Tsyr Chang, Yuh-Ju Sun, Ping-Chiang Lyu, Shu-Chuan Lin, Wei-I Chou
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Publication number: 20130149197Abstract: A biotechnology detection device with optical fibers comprises a first optical fiber connected to a light source, and a prism having a first surface and a second surface. The first surface is connected to the first optical fiber and coated with an anti-reflective layer to be passed through by short-wavelength light; a second optical fiber connected to the second surface of the prism. The end of the second optical fiber is to be coated with test sample blended with a fluorescent agent, wherein the fluorescent agent emits long-wavelength light after being excited by short-wavelength light. The second prism surface is coated with a high reflective layer to reflect part of the long-wavelength light. A third optical fiber is connected to the second prism surface to convey part of the long-wavelength light. A detector is connected to the third optical fiber for detecting part of the long-wavelength light.Type: ApplicationFiled: June 12, 2012Publication date: June 13, 2013Applicant: National Taiwan University of Science and TechnologyInventors: Shien-Kuei Liaw, Chia-Ching Chang, Shin-Hua Tseng, Yi-Lin Yu, Shu-Chuan Lin, Hung-Wei Chen
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Patent number: 8399416Abstract: The present invention is for an isolated peptide consisting of the amino acid sequence of SEQ ID NO: 9 and using the peptide for treating asthma by reducing cytotoxicity of eosinophil derived toxins in bronchial epithelial cells of the subject suffers from asthma. The method comprises preparing a pharmaceutical composition having the peptide of SEQ ID NO: 9 and administering an effective amount of the composition to the subject.Type: GrantFiled: February 27, 2012Date of Patent: March 19, 2013Assignee: National Tsing Hua UniversityInventors: Margaret Dah-Tsyr Chang, Tan-chi Fan, Shu-Chuan Lin
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Patent number: 8372951Abstract: A cell penetrating peptide which has following sequence: NYBX1BX2BNQX3, wherein B represents a basic amino acid, X1 represents an amino acid with an aromatic, a hydrophobic or an uncharged side chain, X2 represents any amino acid, and X3 represents N or none is described. A method for delivering a cargo into a subject by administrating a complex comprising the cell penetrating peptide and the desired cargo to the subject is also described.Type: GrantFiled: May 14, 2010Date of Patent: February 12, 2013Assignee: National Tsing Hua UniversityInventors: Margaret Dah-Tsyr Chang, Shun-Lung Fang, Wei-I Chou, Shu-Chuan Lin
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Patent number: 8293465Abstract: The present invention relates to an antibody mimetic of carbohydrate binding module (CBM) which specifically binds to an epitope on HIV glycoprotein. The present invention also relates to a method of detecting HIV glycoprotein.Type: GrantFiled: April 6, 2010Date of Patent: October 23, 2012Assignee: National Tsing Hua UniversityInventors: Margaret Dah-Tsyr Chang, Yuan-Chuan Lee, Rong-Yuan Huang, Shu-Chuan Lin, Wei-I Chou, Shi-Hwei Liu
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Publication number: 20120214730Abstract: The present invention is for an isolated peptide consisting of the amino acid sequence of SEQ ID NO: 9 and using the peptide for treating asthma by reducing cytotoxicity of eosinophil derived toxins in bronchial epithelial cells of the subject suffers from asthma. The method comprises preparing a pharmaceutical composition having the peptide of SEQ ID NO: 9 and administering an effective amount of the composition to the subject.Type: ApplicationFiled: February 27, 2012Publication date: August 23, 2012Applicant: NATIONAL TSING HUA UNIVERSITYInventors: Margaret Dah-Tsyr Chang, Tan-chi Fan, Shu-Chuan Lin
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Publication number: 20110280798Abstract: The present invention provides a cell penetrating peptide which has following sequence: NYBX1BX2BNQX3, wherein B represents a basic amino acid, X1 represents an amino acid with an aromatic, a hydrophobic or an uncharged side chain, X2 represents any amino acid, and X3 represents N or none. The present invention also provides a method for delivering a cargo into a subject by administrating a complex comprising the cell penetrating peptide and the desired cargo to the subject.Type: ApplicationFiled: May 14, 2010Publication date: November 17, 2011Applicant: NATIONAL TSING HUA UNIVERSITYInventors: Margaret Dah-Tsyr Chang, Shun-Lung Fang, Wei-I Chou, Shu-Chuan Lin
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Publication number: 20110129853Abstract: A polysaccharide-protein binding model of SBD, and a fibril-forming 14-residue peptide consisting of X1NNNX2X3NYQX4X5X6X7X8, wherein the X1 and X8 mean a pair of opposite charged amino acid residues, and the X2, X3, X4, X5, X6, or X7 means an amino acid residue is described. A mixture for diminising a polysaccharide, comprising at least two starch binding domains (SBDs) and a polysaccharide in a helix form is also presented. A method of providing an oligosaccharide, and a method of producing an amyloid-like fibril and use thereof are further described.Type: ApplicationFiled: January 19, 2011Publication date: June 2, 2011Applicant: NATIONAL TSING HUA UNIVERSITYInventors: Margaret Dah-Tsyr Chang, Yuh-Ju Sun, Ping-Chiang Lyu, Shu-Chuan Lin, Wei-I Chou
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Patent number: 7919580Abstract: A polysaccharide-protein binding model of SBD, and a fibril-forming 14-residue peptide consisting of X1NNNX2X3NYQX4X5X6X7X8, wherein the X1 and X8 mean a pair of opposite charged amino acid residues, and the X2, X3, X4, X5, X6, or X7 means an amino acid residue is described. A mixture for diminising a polysaccharide, comprising at least two starch binding domains (SBDs) and a polysaccharide in a helix form is also presented. A method of providing an oligosaccharide, and a method of producing an amyloid-like fibril and use thereof are further described.Type: GrantFiled: January 23, 2009Date of Patent: April 5, 2011Assignee: National Tsing Hua UniversityInventors: Margaret Dah-Tsyr Chang, Yuh-Ju Sun, Ping-Chiang Lyu, Shu-Chuan Lin, Wei-I Chou
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Patent number: 7872122Abstract: A process for making Biolimus A9 comprises reacting sirolimus (or rapamycin) with alkyl benzene sulfonate under the catalyzing of organic base and in the presence of organic solvent to undergo a nucleophilic substitution reaction to obtain the Biolimus A9 with high yield, not only for small-scale laboratory experiment, but also for rendering reproducibility of high yield even after process amplification.Type: GrantFiled: May 8, 2009Date of Patent: January 18, 2011Assignee: Chunghwa Chemical Synthesis & Biotech Co., Ltd.Inventors: Kwang-Chung Lee, Ping-Shu Chen, Shu-Chuan Lin, Tzu-Ai Lee
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Publication number: 20100322624Abstract: The present invention discloses a bidirectional transmission network apparatus based on a tunable rare-earth-doped fiber laser source. It is useful in wavelength-division-multiplexing access networks. The fiber ring laser not only generates downstream data traffic but also serves as the wavelength-selecting injection light source for the Fabry-PĂ©rot lasers (or vertical cavity surface emitting lasers) located at the subscriber site. The fiber laser is constructed based on optical filtering, polarization control and noise suppression techniques.Type: ApplicationFiled: August 22, 2008Publication date: December 23, 2010Applicant: National Taiwan University of Science and TechnologyInventors: CHENG-KUANG LIU, SAN-LIANG LEE, CHIH-LUNG TSENG, JAU-JI JOU, SHU-CHUAN LIN
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Publication number: 20100291601Abstract: The present invention relates to an antibody mimetic of carbohydrate binding module (CBM) which specifically binds to an epitope on HIV glycoprotein. The present invention also relates to a method of detecting HIV glycoprotein.Type: ApplicationFiled: April 6, 2010Publication date: November 18, 2010Applicant: NATIONAL TSING HUA UNIVERSITYInventors: Margaret Dah-Tsyr Chang, Yuan-Chuan Lee, Rong-Yuan Huang, Shu-Chuan Lin, Wei-I Chou, Shi-Hwei Liu
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Publication number: 20100291540Abstract: The present invention relates to an antibody mimetic of carbohydrate binding module (CBM) which specifically binds to an epitope on HIV glycoprotein. The present invention also relates to a method of detecting HIV glycoprotein.Type: ApplicationFiled: May 12, 2009Publication date: November 18, 2010Applicant: NATIONAL TSING HUA UNIVERSITYInventors: Margaret Dah-Tsyr Chang, Yuan-Chuan Lee, Rong-Yuan Huang, Shu-Chuan Lin, Wei-I Chou, Shi-Hwei Liu
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Publication number: 20100016239Abstract: A method for reducing cytotoxicity of eosinophil derived toxins comprising administering to a subject an effective amount of heparin, heparan sulfate, a potent heparanase inhibitor or a polypeptide which has sequence as follows: BZBXBX, XBBBXXBX, XBBXBX, BBXXBBBXXBB, BXBBXB, XBBBXXBBBXXBBX, or TXXBXXTBXXXTBB, wherein X represents any amino acid, Z represents an aromatic amino acid, and B represents a basic amino acid and T represents a turn.Type: ApplicationFiled: August 21, 2009Publication date: January 21, 2010Applicant: NATIONAL TSING HUA UNIVERSITYInventors: Margaret Dah-Tsyr Chang, Tan-chi Fan, Shu-Chuan Lin
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Publication number: 20090292118Abstract: A process for making Biolimus A9 comprises reacting sirolimus (or rapamycin) with alkyl benzene sulfonate under the catalyzing of organic base and in the presence of organic solvent to undergo a nucleophilic substitution reaction to obtain the Biolimus A9 with high yield, not only for small-scale laboratory experiment, but also for rendering reproducibility of high yield even after process amplification.Type: ApplicationFiled: May 8, 2009Publication date: November 26, 2009Inventors: Kwang-Chung Lee, Ping-Shu Chen, Shu-Chuan Lin, Tzu-Ai Lee
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Patent number: 7595374Abstract: A method for reducing cytotoxicity of eosinophil derived toxins comprising administering to a subject an effective amount of heparin, heparan sulfate, a potent heparanase inhibitor or a polypeptide which has sequence as follows: BZBXBX, XBBBXXBX, XBBXBX, BBXXBBBXXBB, BXBBXB, XBBBXXBBBXXBBX, or TXXBXXTBXXXTBB, wherein X represents any amino acid, Z represents an aromatic amino acid, and B represents a basic amino acid and T represents a turn.Type: GrantFiled: May 21, 2008Date of Patent: September 29, 2009Assignee: National Tsing Hua UniversityInventors: Margaret Dah-Tsyr Chang, Tan-chi Fan, Shu-Chuan Lin
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Publication number: 20090186369Abstract: The present invention relates to a polysaccharide-protein binding model of SBD, and a fibril-forming 14-residue peptide consisting of X1NNNX2X3NYQX4X5X6X7X8, wherein the X1 and X8 mean a pair of opposite charged amino acid residues, and the X2, X3, X4, X5, X6, or X7 means an amino acid residue. The present invention also relates to a mixture for diminising a polysaccharide, comprising at least two starch binding domains (SBDs) and a polysaccharide in a helix form. The present invention further relates to a method of providing an oligosaccharide, and a method of producing an amyloid-like fibril and use thereof.Type: ApplicationFiled: January 23, 2009Publication date: July 23, 2009Applicant: NATIONAL TSING HUA UNIVERSITYInventors: Margaret Dah-Tsyr Chang, Yuh-Ju Sun, Ping-Chiang Lyu, Shu-Chuan Lin, Wei-I Chou
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Patent number: 7019133Abstract: A process for making mycophenolate mofetil comprising: conducting a catalytic transesterification by reacting a low-carbon alkyl ester of mycophenolic acid with 2-morpholinoethanol [also named as 4-(2-hydroxyethyl) morpholine] to obtain a crude product of mycophenolate mofetil, which is then isolated and purified.Type: GrantFiled: December 29, 2003Date of Patent: March 28, 2006Assignee: Chunghwa Chemical Synthesis & Biotech Co., Ltd.Inventors: Kwang-Chung Lee, Shu-Chuan Lin, Ray-Hwa Chiu
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Publication number: 20040167130Abstract: A process for making mycophenolate mofetil comprising: conducting a catalytic transesterification by reacting a low-carbon alkyl ester of mycophenolic acid with 2-morpholinoethanol [also named as 4-(2-hydroxyethyl) morpholine] to obtain a crude product of mycophenolate mofetil, which is then isolated and purified.Type: ApplicationFiled: December 29, 2003Publication date: August 26, 2004Inventors: Kwang-Chung Lee, Shu-Chuan Lin, Ray-Hwa Chiu