Abstract: The present invention relates to antigen-binding molecules binding to CD3 and CD137 (4-1BB); compositions comprising the antigen-binding molecule; and methods of using the same. The present invention provides antigen-binding molecules comprising: an antibody variable region that is capable of binding to CD3 and CD137 (4-1BB), but does not bind to CD3 and CD137 at the same time; and a variable region binding to a third antigen different from CD3 and CD137. Such antigen binding molecules exhibit enhanced T-cell dependent cytotoxity activity induced by these antigen-binding molecules through binding to the three different antigens.

Abstract: The disclosure provides multispecific antigen-binding molecules that comprise a first antigen-binding moiety and a second antigen-binding moiety, each of which is capable of binding to CD3 and CD137, but does not bind to CD3 and CD137 at the same time; and a third antigen-binding moiety that is capable of binding to DLL3, preferably human DLL3, which induce T-cell dependent cytotoxity more efficiently whilst circumventing adverse toxicity concerns or side effects that other multispecific antigen-binding molecules may have. The present invention provides multispecific antigen-binding molecules and pharmaceutical compositions that can treat various cancers, especially those associated with DLL3, by comprising the antigen-binding molecule as an active ingredient.

Abstract: A manufacturing method of a battery structure is provided. A packing is provided, wherein the packing pre-forms an accommodating space. A first battery unit is disposed into the accommodating space, wherein the first battery unit includes at least one anode and at least one cathode alternately stacked with each other and a dielectric layer located between the anode and the cathode. A separation membrane is disposed into the accommodating space and located on the first battery unit. A second battery unit is stacked onto the separation membrane, located in the accommodating space and includes at least one anode and at least one cathode alternately stacked with each other and a dielectric layer located between the anode and the cathode. A dimension of the first battery unit is smaller than a dimension of the second battery unit. Electrolytes is injected into the accommodating space. The packing is sealed.

Abstract: The present invention relates to bispecific anti-CCL2 antibodies binding to two different epitopes on human CCL2, pharmaceutical compositions thereof, their manufacture, and use as medicaments for the treatment of cancers, inflammatory, autoimmune and ophthalmologic diseases.

Abstract: The invention provides anti-C1s antibodies and methods of using the same. The affinities of the antibodies to C1s depend on pH and other conditions. The invention also provides pharmaceutical formulations comprising the antibodies, and methods of treating an individual having a complement-mediated disease or disorder comprising administering the antibody to the individual. In addition, the binding affinity of the antibody at high and low pH was measured, and mice PK study was conducted on the antibodies, and pharmacokinetics parameters of the antibodies were evaluated in this application.

Abstract: A dual gate transistor circuit, a pixel circuit, and a gate drive circuit are provided. The dual gate transistor circuit includes a dual gate transistor, a first diode, and a second diode. The dual gate transistor has a first gate and a second gate, and the first gate receives a drive signal. The first diode is connected in series between the first gate and the second gate according to a first-polarity direction. The second diode is connected in series between the first gate and the second gate according to a second-polarity direction. The first-polarity direction is opposite to the second-polarity direction.

Abstract: A manufacturing method of a battery structure is provided. A packing is provided, wherein the packing pre-forms an accommodating space. A first battery unit is disposed into the accommodating space, wherein the first battery unit includes at least one anode and at least one cathode alternately stacked with each other and a dielectric layer located between the anode and the cathode. A separation membrane is disposed into the accommodating space and located on the first battery unit. A second battery unit is stacked onto the separation membrane, located in the accommodating space and includes at least one anode and at least one cathode alternately stacked with each other and a dielectric layer located between the anode and the cathode. A dimension of the first battery unit is smaller than a dimension of the second battery unit. Electrolytes is injected into the accommodating space. The packing is sealed.

Abstract: A dual gate transistor circuit, a pixel circuit, and a gate drive circuit are provided. The dual gate transistor circuit includes a dual gate transistor, a first diode, and a second diode. The dual gate transistor has a first gate and a second gate, and the first gate receives a drive signal. The first diode is connected in series between the first gate and the second gate according to a first-polarity direction. The second diode is connected in series between the first gate and the second gate according to a second-polarity direction. The first-polarity direction is opposite to the second-polarity direction.

Abstract: A battery structure including a first battery unit, a second battery unit, a separation membrane and a packing is provided. The first and the second battery units respectively include at least one anode, at least one cathode and a dielectric layer located between the at least one anode and the at least one cathode close to each other. The at least one anode and the at least one cathode are alternately stacked with each other. The second battery unit is stacked on the first battery unit. A dimension of the first battery unit is smaller than that of the second battery unit. The separation membrane is disposed between the first and the second battery units. The packing covers the first and the second battery units and the separation membrane. An electronic device including the battery structure, and a manufacturing method of the battery structure, are further provided.

Abstract: Conjugates are provided containing a graphene quantum dot, a targeting moiety, and an active agent. The conjugates can be used to provide one or more therapeutic, prophylactic, or diagnostic effects to a subject in need thereof. The subject can be a cancer patient and the active agent an anti-cancer agent. The graphene quantum dots can have an average particle size of about 1-20 nm and a monodisperse size distribution. The size distribution can have a span about 1 or less and/or a coefficient of variance of about 0.5 or less. Methods of making the conjugates are provided. The methods can include conjugating the targeting moiety to the GQD using a reactive coupling group. Methods of treating, preventing, and/or diagnosing a disease or disorder in a patient in need thereof by administering the conjugates are provided.

Abstract: A method of identifying information during navigation is provided. Fork data is extracted from navigation data, the fork data corresponding to a road having a fork. A first node and at least two exit roads are extracted from the fork data, the at least two exit roads being roads in different directions. The fork data are identified as corresponding to a target fork in response to all of the at least two exit roads converging at the first node. A second node adjacent to the first node is queried in response to at least two exit roads not completely converging at the first node. The fork data are identified as corresponding to the target fork based on a distance between the first node and the second node meeting a preset condition.

Abstract: A battery module including a connection terminal, a first battery, a second battery and a current limiting circuit is provided. The connection terminal serves as a power input terminal of the battery module during the charging of the battery module, and serves as a power output terminal of the battery module during the discharging of the battery module. The first battery is coupled to the connection terminal, and serves as a primary power source of a mobile device. The second battery serves as an auxiliary power source of the mobile device. The current limiting circuit is coupled between the second battery and the connection terminal, and restricts the magnitudes of the currents flowing into and out of the second battery according to a charging current threshold and a discharging current threshold.

Abstract: Inclusion complexes are provided containing a targeted carrier non-covalently associated with an active agent. The targeted carrier includes an inclusion host that binds the active agent or a binding partner attached to the active agent. The targeted carrier includes a targeting moiety attached to the inclusion host or to a polymer or linker attached thereto. Pharmaceutical formulations of the inclusion complexes are provided. Methods of making the inclusion complexes and formulations thereof are provided. Methods of using the inclusion complexes and formulations are provided. In some embodiments the inclusion complex includes a progesterone or estrogen targeting moiety that targets the inclusion complex to cancer cells. The targeting can cause internalization of the active agent in the target cells. In some embodiments the active agent is an anthracycline such as doxorubicin and the target cells are cancer cells.

Abstract: Methods of making graphene quantums dots are provided. The methods can produce graphene quantum dots with a monodisperse size distribution. The graphene quantum dots are produced, via one-pot synthesis, from a graphene source and a strong oxidizing mixture at an elevated temperature. The strong oxidizing mixture can contain one or more permanganates and one or more oxidizing acids. Exemplary permanganates include sodium permanganate, potassium permanganate, and calcium permanganate. Exemplary oxidizing acids include nitric acid and sulfuric acid. The graphene quantum dots can have an average particle size of between about 1 nm and 20 nm and a monodisperse size distribution. For example, the size distribution can have a span about 1 or less and/or a coefficient of variance of about 0.5 or less. About 40% or more of the graphene quantum dots can have a diameter within ±5 nm of the average particle size of the graphene quantum dots.

Abstract: A polymer and a pharmaceutical composition employing the same are disclosed. The polymer includes a first repeating unit, a second repeating unit, and a third repeating unit. In particular, the first repeating unit is the second repeating unit is wherein R1 is C1-6 alkyl group; and the third repeating unit is wherein X is and Y is a hydrophilic polymeric moiety.

Abstract: Methods of making graphene quantums dots are provided. The methods can produce graphene quantum dots with a monodisperse size distribution. The graphene quantum dots are produced, via one-pot synthesis, from a graphene source and a strong oxidizing mixture at an elevated temperature. The strong oxidizing mixture can contain one or more permanganates and one or more oxidizing acids. Exemplary permanganates include sodium permanganate, potassium permanganate, and calcium permanganate. Exemplary oxidizing acids include nitric acid and sulfuric acid. The graphene quantum dots can have an average particle size of between about 1 nm and 20 nm and a monodisperse size distribution. For example, the size distribution can have a span about 1 or less and/or a coefficient of variance of about 0.5 or less. About 40% or more of the graphene quantum dots can have a diameter within ±5 nm of the average particle size of the graphene quantum dots.

Abstract: A polymer and a pharmaceutical composition employing the same are disclosed. The polymer includes a first repeating unit, a second repeating unit, and a third repeating unit. In particular, the first repeating unit is the second repeating unit is wherein R1 is C1-6 alkyl group; and the third repeating unit is wherein X is and Y is a hydrophilic polymeric moiety.

Abstract: A semiconductor device and a manufacturing method thereof are provided. The semiconductor device includes a gate, a channel layer, a gate insulation layer, a source, a drain and a silicon-aluminum-oxide layer. The gate is disposed on a substrate. The channel layer is disposed on the substrate. The channel layer overlaps the gate. The gate insulation layer is disposed between the gate and the channel layer. The source and the drain are disposed on two sides of the channel layer. The silicon-aluminum-oxide layer is disposed on the substrate and covers the source, the drain and the channel layer.

Abstract: A battery structure including a first battery unit, a second battery unit, a separation membrane and a packing is provided. The first and the second battery units respectively include at least one anode, at least one cathode and a dielectric layer located between the at least one anode and the at least one cathode close to each other. The at least one anode and the at least one cathode are alternately stacked with each other. The second battery unit is stacked on the first battery unit. A dimension of the first battery unit is smaller than that of the second battery unit. The separation membrane is disposed between the first and the second battery units. The packing covers the first and the second battery units and the separation membrane. An electronic device including the battery structure, and a manufacturing method of the battery structure, are further provided.

Abstract: A thin-film transistor (TFT) includes a gate electrode, a gate dielectric layer, a semiconductor layer, source/drain electrodes, a passivation layer and a protection layer. The gate electrode is disposed on a substrate. The gate dielectric layer covers the gate electrode and the substrate. The semiconductor layer is disposed on the gate dielectric layer and above the gate electrode. The semiconductor layer has a channel region disposed above the gate electrode and source/drain regions disposed at both sides of the channel region. The source/drain electrodes are disposed on the source/drain regions of the semiconductor layer and each has a barrier layer disposed on the source/drain regions of the semiconductor layer and a conductive layer disposed on the barrier layer. The passivation layer is disposed over the surface of the source/drain electrodes. The protection layer is disposed over the substrate, the passivation layer, and the channel region of the semiconductor layer.