Patents by Inventor Shu-Hai Zhao

Shu-Hai Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antiviral compounds
    Patent number: 9403805
    Abstract: The present invention provides compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: August 2, 2016
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Adrian Wai-Hing Cheung, Ryan Craig Schoenfeld, Weiya Yun, Shu-Hai Zhao
  • Novel indazoles for the treatment and prophylaxis of respiratory syncytial virus infection
    Publication number: 20160200741
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R7, A1, A2 and A3 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: November 18, 2015
    Publication date: July 14, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Song FENG, LU GAO, Di HONG, Lisha WANG, Hongying YUN, Shu-Hai ZHAO
  • Indazoles for the treatment and prophylaxis of respiratory syncytial virus infection
    Patent number: 9206191
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R7, A1, A2 and A3 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: December 8, 2015
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Song Feng, Lu Gao, Di Hong, Lisha Wang, Hongying Yun, Shu-Hai Zhao
  • Antiviral Compounds
    Publication number: 20150274711
    Abstract: The present invention provides compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
    Type: Application
    Filed: June 9, 2015
    Publication date: October 1, 2015
    Inventors: Adrian Wai-Hing Cheung, Ryan Craig Schoenfeld, Weiya Yun, Shu-Hai Zhao
  • Antiviral compounds
    Patent number: 9090559
    Abstract: The present invention provides compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: July 28, 2015
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Adrian Wai-Hing Cheung, Ryan Craig Schoenfeld, Weiya Yun, Shu-Hai Zhao
  • Novel indazoles for the treatment and prophylaxis of respiratory syncytial virus infection
    Publication number: 20150158879
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R7, A1, A2 and A3 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: January 9, 2015
    Publication date: June 11, 2015
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Song Feng, Lu Gao, Di Hong, Lisha Wang, Hongying Yun, Shu-Hai Zhao
  • ANTIVIRAL COMPOUNDS
    Publication number: 20150005283
    Abstract: The present invention provides compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
    Type: Application
    Filed: February 21, 2013
    Publication date: January 1, 2015
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Adrian Wai-Hing Cheung, Ryan Craig Schoenfeld, Weiya Yun, Shu-Hai Zhao
  • BENZOXAZINE DERIVATIVES AND USES THEREOF
    Publication number: 20130123251
    Abstract: The present invention provides a compound of the formula: a pharmaceutically acceptable salt or a prodrug thereof, where R1, R2, R3, R4, R5, R6, R7, R8, R9, Y, Z1, m, n, and p are as defined herein. The present invention also provides compositions comprising, methods for using, and methods for preparing Compound of Formula I.
    Type: Application
    Filed: December 13, 2012
    Publication date: May 16, 2013
    Applicant: ROCHE PALO ALTO LLC
    Inventors: Jacob Berger, Robin Douglas Clark, Shu-Hai Zhao
  • Benzoxazine derivatives and uses thereof
    Patent number: 8377931
    Abstract: The present invention provides a compound of the formula: a pharmaceutically acceptable salt or a prodrug thereof, where R1, R2, R3, R4, R5, R6, R7, R8, R9, Y, Z1, m, n, and p are as defined herein. The present invention also provides compositions comprising, methods for using, and methods for preparing Compound of Formula I.
    Type: Grant
    Filed: September 4, 2009
    Date of Patent: February 19, 2013
    Assignee: Roche Palo Alto LLC
    Inventors: Jacob Berger, Robin Douglas Clark, Shu-Hai Zhao
  • Dihydropyridone amides as P2Xmodulators
    Patent number: 8372865
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4, R5 and Ra are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: February 12, 2013
    Assignee: Roche Palo Alto LLC
    Inventors: Jacob Berger, Joan Marie Caroon, Nancy Elisabeth Krauss, Keith Adrian Murray Walker, Shu-Hai Zhao, Francisco Javier Lopez-Tapia
  • Dihydropyridone amidesas P2Xmodulators
    Patent number: 8288552
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4, R5 and Ra are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: October 16, 2012
    Assignee: Roche Palo Alto LLC
    Inventors: Jacob Berger, Joan Marie Caroon, Francisco Javier Lopez-Tapia, Dov Nitzan, Keith Adrian Murray Walker, Shu-Hai Zhao
  • ANTIVIRAL COMPOUNDS
    Publication number: 20120230951
    Abstract: The present invention provides compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
    Type: Application
    Filed: March 8, 2012
    Publication date: September 13, 2012
    Inventors: Muzaffar Alam, Steven Joseph Berthel, John A. Brinkman, Ronald Charles Hawley, Hongju Li, Wylie Solang Palmer, Sherrie Pietranico-Cole, Ramakanth Sarabu, Mark Smith, Sung-Sau So, Lin Yi, Yansheng Zhai, Qiang Zhang, Shu-Hai Zhao
  • Dihydropyridone amides as P2Xmodulators
    Patent number: 8163929
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, R1, R2, R3, R4, R5 and R6 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: April 24, 2012
    Assignee: Roche Palo Alto LLC
    Inventors: Jacob Berger, Christine E. Brotherton-Pleiss, Francisco Javier Lopez-Tapia, Keith Adrian Murray Walker, Shu-Hai Zhao
  • Dihydropyridone amides as P2X7 modulators
    Patent number: 8153808
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
    Type: Grant
    Filed: December 14, 2009
    Date of Patent: April 10, 2012
    Assignee: Roche Palo Alto LLC
    Inventors: Francisco Javier Lopez-Tapia, Keith Adrian Murray Walker, Shu-Hai Zhao
  • Hepatitis C Virus Inhibitors
    Publication number: 20120039847
    Abstract: The present invention provides compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
    Type: Application
    Filed: August 12, 2011
    Publication date: February 16, 2012
    Inventor: Shu-Hai Zhao
  • Chroman derivatives and uses thereof
    Patent number: 7759389
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1, R2, R3 and R4 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: July 20, 2010
    Assignee: Roche Palo Alto LLC
    Inventors: Nancy Elisabeth Krauss, Shu-Hai Zhao
  • Arylsulfonyl chromans as 5-HTinhibitors
    Patent number: 7754759
    Abstract: Compounds of the formula I: wherein m, n, p, X, Ar, R1, R2, R3, R4 and R5 are as defined herein. Methods of making the compounds and using the compounds for treatment of 5-HT6 receptor-mediated diseases are disclosed.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: July 13, 2010
    Assignee: Roche Palo Alto LLC
    Inventors: Jacob Berger, Joan Marie Caroon, Francisco Javier Lopez-Tapia, Lee Edwin Lowrie, Jr., Dov Nitzan, Shu-Hai Zhao
  • DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS
    Publication number: 20100160373
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4, R5 and Ra are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
    Type: Application
    Filed: December 15, 2009
    Publication date: June 24, 2010
    Inventors: Jacob Berger, Joan Marie Caroon, Nancy Elisabeth Krauss, Keith Adrian Murray Walker, Shu-Hai Zhao, Francisco Javier Lopez-Tapia
  • DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS
    Publication number: 20100160384
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, R1, R2, R3, R4, R5 and R6 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
    Type: Application
    Filed: December 15, 2009
    Publication date: June 24, 2010
    Inventors: Jacob Berger, Christine E. Brotherton-Pleiss, Francisco Javier Lopez-Tapia, Keith Adrian Murray Walker, Shu-Hai Zhao
  • DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS
    Publication number: 20100160387
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
    Type: Application
    Filed: December 14, 2009
    Publication date: June 24, 2010
    Inventors: Francisco Javier Lopez-Tapia, Keith Adrian Murray Walker, Shu-Hai Zhao