Patents by Inventor Shu-Hong Zhang

Shu-Hong Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of preparing retroviral proteases inhibitor intermediates
    Publication number: 20060270855
    Abstract: Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtaining such key chiral amine intermediates enantiomerically, diastereomerically and chemically pure. The method is suitable for large scale (multikilogram) productions. This invention also encompasses organic acid and inorganic acid salts of the amine intermediates.
    Type: Application
    Filed: May 16, 2006
    Publication date: November 30, 2006
    Applicant: G.D. Searle & Co.
    Inventors: John Ng, Claire Przybyla, Shu-Hong Zhang
  • Method of preparing retroviral protease inhibitor intermediates
    Patent number: 7060851
    Abstract: Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtaining such key chiral amine intermediates enantiomerically, diastereomerically and chemically pure. The method is suitable for large scale (multikilogram) productions. This invention also encompasses organic acid and inorganic acid salts of the amine intermediates.
    Type: Grant
    Filed: October 12, 2004
    Date of Patent: June 13, 2006
    Assignee: G.D. Searle & Co.
    Inventors: John S Ng, Claire A Przybyla, Shu-Hong Zhang
  • Method of preparing retroviral protease inhibitor intermediates
    Publication number: 20050131075
    Abstract: Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtaining such key chiral amine intermediates enantiomerically, diasteredmerically and chemically pure. The method is suitable for large scale (multikilogram) productions. This invention also encompasses organic acid and inorganic acid salts of the amine intermediates.
    Type: Application
    Filed: October 12, 2004
    Publication date: June 16, 2005
    Applicant: G.D. Searle & Co.
    Inventors: John Ng, Claire Przybyla, Shu-Hong Zhang
  • Method of preparing retroviral protease inhibitor intermediates
    Patent number: 6849760
    Abstract: Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtaining such key chiral amine intermediates enantiomerically, diastereomerically and chemically pure. The method is suitable for large scale (multikilogram) productions. This invention also encompasses organic acid and inorganic acid salts of the amine intermediates.
    Type: Grant
    Filed: December 23, 2002
    Date of Patent: February 1, 2005
    Assignee: G. D. Searle & Co.
    Inventors: John S Ng, Claire S Przybyla, Shu-Hong Zhang
  • Method of preparing retroviral protease inhibitor intermediates
    Publication number: 20030171612
    Abstract: Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtaining such key chiral amine intermediates enantiomerically, diastereomerically and chemically pure. The method is suitable for large scale (multikilogram) productions. This invention also encompasses organic acid and inorganic acid salts of the amine intermediates.
    Type: Application
    Filed: December 23, 2002
    Publication date: September 11, 2003
    Applicant: G.D. Searle & Co.
    Inventors: John S. Ng, Claire A. Przybyla, Shu-Hong Zhang
  • Method of preparing retroviral protease inhibitor intermediates
    Patent number: 6515162
    Abstract: Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtaining such key chiral amine intermediates enantiomerically, diastereomerically and chemically pure. The method is suitable for large scale (multikilogram) productions. This invention also encompasses organic acid and inorganic acid salts of the amine intermediates.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: February 4, 2003
    Assignee: G.D. Searle & Co.
    Inventors: John S Ng, Claire S. Przybyla, Shu-Hong Zhang
  • Method of preparing retroviral protease inhibitor intermediates
    Publication number: 20010047111
    Abstract: Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtaining such key chiral amine intermediates enantiomerically, diastereomerically and chemically pure. The method is suitable for large scale (multikilogram) productions. This invention also encompasses organic acid and inorganic acid salts of the amine intermediates.
    Type: Application
    Filed: December 21, 2000
    Publication date: November 29, 2001
    Inventors: John S. Ng, Claire A. Przybyla, Shu-Hong Zhang
  • Method of preparing retroviral protease inhibitor intermediates
    Patent number: 6201150
    Abstract: Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtaining such key chiral amine intermediates enantiomerically, diastereomerically and chemically pure. The method is suitable for large scale (multikilogram) productions. This invention also encompasses organic acid and inorganic acid salts of the amine intermediates.
    Type: Grant
    Filed: February 17, 1998
    Date of Patent: March 13, 2001
    Assignee: G.D. Searle & Co.
    Inventors: John S Ng, Claire S Przybyla, Shu-Hong Zhang
  • Method of preparing retroviral protease inhibitor intermediates
    Patent number: 5831117
    Abstract: Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtaining such key chiral amine intermediates enantiomerically, diastereomerically and chemically pure. The method is suitable for large scale (multikilogram) productions. This invention also encompasses organic acid and inorganic acid salts of the amine intermediates.
    Type: Grant
    Filed: January 20, 1995
    Date of Patent: November 3, 1998
    Assignee: G. D. Searle & Co.
    Inventors: John S. Ng, Claire A. Przybyla, Shu-Hong Zhang