Patents by Inventor Shu-Jen David Chiang

Shu-Jen David Chiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for hydroxylating epothilones
    Patent number: 7214527
    Abstract: Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.
    Type: Grant
    Filed: August 9, 2004
    Date of Patent: May 8, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jonathan David Basch, Shu-Jen David Chiang, Suo-Win Liu, Akbar Nayeem, Yuhua Sun, Li You
  • Compositions and methods for hydroxylating epothilones
    Patent number: 6884608
    Abstract: Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.
    Type: Grant
    Filed: December 17, 2002
    Date of Patent: April 26, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jonathan David Basch, Shu-Jen David Chiang, Suo-Win Liu, Akbar Nayeem, Yuhua Sun, Li You
  • Compositions and methods for hydroxylating epothilones
    Publication number: 20030180760
    Abstract: Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.
    Type: Application
    Filed: December 17, 2002
    Publication date: September 25, 2003
    Inventors: Jonathan David Basch, Shu-Jen David Chiang, Suo-Win Liu, Akbar Nayeem, Yuhua Sun, Li You
  • Direct production of desacetylcephalosporin C
    Publication number: 20020048781
    Abstract: The present invention concerns the direct production of desacetylcephalosporin C by culturing a strain of Acremonium chrysogenum containing recombinant nucleic acid encoding Rhodosporidium toruloides cephalosporin esterase.
    Type: Application
    Filed: March 8, 2001
    Publication date: April 25, 2002
    Inventors: Shu-Jen David Chiang, Jonathan David Basch