Abstract: A novel polymer-supported arene-ruthenium complex represented by the following formula: , wherein A represents an organic polymer with a side chain containing an aromatic ring coordinated to Ru, X1 and X2 represent the same or different halogen atoms, and R represents a hydrocarbon group that may have a substituent is provided for use as a catalyst. This novel polymer-supported arene-ruthenium complex and catalyst thereof can be produced by a simple process, are stable and easy to recover, have a high catalytic activity, and can be used for various organic synthesis reactions. Novel methods for an organic synthesis reaction such as ring-opening metathesis reaction of an olefin compound and reduction of a carbonyl group, using the catalyst are provided.

Abstract: The objective is to present compositions obtained by supporting by polymers micro clusters of transition metals and the like that are useful as catalysts in various reactions and, once used, are readily recovered and reused. A polymer-supported metal cluster composition is obtained by supporting a transition metal by a cross-linked polymer, and the polymer-supported cluster composition is characterized by the cross-linked polymer obtained by cross-linking of a cross-linkable polymer containing a hydrophilic side chain and a hydrophobic side chain group having a cross-linkable functional group. This polymer-supported metal cluster composition is, for example, preferably formed by first forming a micelle composed of the metal clusters supported by the cross-linkable polymer in a suitable solution and subsequently subjecting the cross-linkable polymer to a cross-linking reaction.

Abstract: A method for aldol reaction in water, which comprises: reacting an aldehyde with a silyl enol ether in an aqueous medium in the presence of a boronic acid represented by the following general formula (1): R1R2BOH??(1) (wherein R1 and R2 are the same or different hydrocarbon groups that may contain a substituent), a surfactant, and a Brønsted acid is provided. This method for aldol reaction in water uses a catalytic amount of the boron source to give products in high yield and selectivity.

Abstract: A microencapsulated Group VIII metal catalyst which is stable even in air, easy to recover, and reusable is disclosed. It comprises a polymer with side chains containing an aromatic substituent, and a metal catalyst comprising a Group VIII metal encapsulated in to this polymer.

Abstract: An asymmetric reaction catalyst is obtained by mixing a pentavalent niobium compound and an optically active triol or tetraol having a binaphthol structure of R or S configuration, and the triol is represented by the following formula: (wherein, Y is divalent hydrocarbon and R1 is a hydrogen atom, a halogen atom, a trifluoromethyl group, or an alkyl group or alkoxy group having at most 4 carbons).

Abstract: An aldol reaction in an aqueous solution between an aldehyde represented by the following formula (I): R—CHO??(I) (wherein R is a hydrocarbon group which may have an substituent), and a silicon enolate represented by the following formula (II): (wherein R1 and R2 are a hydrogen atom or an aliphatic hydrocarbon group, at least one of them being an aliphatic hydrocarbon group; and R3 is a substituent selected from the group consisting of an aliphatic hydrocarbon group, an aromatic hydrocarbon group and a sulfur-containing substituent, wherein R2 and R3 may be combined with each other to form a ring) is performed so as to generate diastereoselectivity by using FeCl3, which is a low-cost Lewis acid, and a surfactant.

Abstract: A novel method of an amidocarbonylation reaction among an aldehyde compound, an amide compound, and carbon monoxide, which comprises using a palladium-supporting crosslinked-polymer composition containing palladium clusters having a major-axis length of 20 nm or shorter to conduct the amidocarbonylation reaction. Thus, an N-acyl-?-amino acid can be more efficiently and selectively synthesized in a dean reaction system. Also provided is a catalyst for use in the method.

Abstract: A method of the intramolecular and intermolecular cyclization of an N-acylhydrazone for obtaining a pyrazoline skeleton or pyrazolidine skeleton under ordinary conditions with high stereoselectivity and in high yield. An N-acylhydrazone represented by the following formula (I): (wherein R1 and R2 are the same or different and each represents hydrogen or a hydrocarbon group and Ar represents an optionally substituted aromatic hydrocarbon group) is converted to an N-acylpyrazoline derivative with high stereoselectivity in the presence of a Lewis acid catalyst or asymmetric Lewis acid catalyst.

Abstract: The objective is to incarcerate a Lewis acid metal in a polymer and to make this catalyst recoverable while maintaining its function as a Lewis acid metal catalyst. The present invention is a polymer-incarcerated Lewis acid metal catalyst in which a Lewis acid metal is incarcerated in a crosslinked polymer and the crosslinked polymer is crosslinked using the crosslinking groups contained in a crosslinkable polymer. The polymer incarcerated Lewis acid metal catalyst is characterized by the crosslinkable polymer containing at least one type of monomer unit containing hydrophobic substituents and hydrophilic substituents containing crosslinking groups, and the hydrophobic substituents contain aromatic substituents. This crosslinkable polymer preferably comprises at least one type of monomer unit containing hydrophobic substituents and hydrophilic substituents containing crosslinking groups and a monomer unit containing hydrophobic substituents.

Abstract: An asymmetric synthesis of amino acid compound that is useful as a starting material or synthetic intermediate for production of medicinal products, agrichemicals, perfumes, functional polymers, etc. There is provided a method of enanthio-selective nucleophilic addition reaction to imine compound being a method of nucleophilic addition reaction of enamide compound accompanied by amino formation to imino group (—CH?N—) of imine compound, characterized in that the reaction is performed in the presence of a chiral copper catalyst. Further, there is provided a novel method of synthesizing an amino acid compound, etc., to which the above is applied.

Abstract: A method of catalytic reaction uses a micro-reactor (1) with a metal catalyst (5) or a metal complex catalyst (5) as a solid phase supported on the inner wall (4c) of a channel (4), a solution (7) dissolving a reactant as a liquid phase and hydrogen (9) as a gas phase are flown through the channel (4) in pipe flow state, and the reaction of the solution (7) and the gas (9) accelerated by the metal catalyst (5) or the metal complex catalyst (5) is conducted by three phase catalytic reaction of solid-liquid-gas phases. The metal catalyst (5) or the metal complex catalyst (5) is incorporated in a polymer, and hydrogenation reaction by three phase catalytic reductive reaction of a substance to be reduced can be conducted in short time at good yield. For hydrogenation reaction of unsaturated organics, the rate of reaction and yield are high when palladium catalyst is used, and carbonylation reaction can be conducted if carbon monoxide is used instead of hydrogen.

Abstract: To present a reaction system that efficiently catalyzes an enantio selective asymmetric nucleophilic addition reaction of an ?-iminophosphonic acid ester. An optically active ?-amino-?-oxophosphonic acid derivative is produced through an asymmetric addition reaction of an ?-iminophosphonic acid ester and a nucleophilic agent (for example, a silyl enol ether).

Abstract: [PROBLEMS] To provide a novel method for the allylation of N-acylhydrazones by which enantioselectively allylated N-acylhydrazines can be efficiently obtained. [MEANS FOR SOLVING PROBLEMS] A method for the production of enantioselectively allylated N-acylhydrazines represented by the general formula [3]: [wherein R0 is an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, or —COOR1 (wherein R1 is a hydrocarbon group); R2 is acyl; R3 and R4 are each hydrogen, or one of R3 and R4 is hydrogen and the other is a hydrocarbon group; and R5 and R6 are each independently hydrogen or a hydrocarbon group], characterized by reacting an N-acylhydrazone represented by the general formula [1]: [wherein R0 and R2 are as defined above] with an allylating agent such as allyltrichlorosilane or crotyltrichlorosilane in the presence of a chiral phosphine oxide.

Abstract: An anilide is reacted with an acylating agent by using as a catalyst a tri(perfluoroalkane sulfonate) compound of any of the elements belonging to groups 3 to 5 and groups 13 to 15 in periods 4 to 6 of the periodic table, thereby bonding an acyl group to the benzene ring. Thus, ketoaniline derivatives, which are useful as physiologically active compounds or intermediates in synthesizing the same, are synthesized in high reaction yield by catalytic acylation.

Abstract: A method of an enantioselective nucleophilic addition reaction to carbonyl, which enables an asymmetric synthesis of an optically active ?-hydroxy-?-keto acid ester, an optically active ?-hydroxy-?-amino acid ester, hydroxydiketone compounds, etc. being useful as a raw material or synthesis intermediate for producing a pharmaceutical preparation, an agricultural chemical, a fragrance, a functional polymer or the like. In this method, the nucleophilic addition reaction of enamide compound accompanied by hydroxyl (—OH) formation to carbonyl is carried out in the presence of a chiral catalyst with copper or nickel.

Abstract: A conjugate addition reaction between an ?,?-unsaturated ketone compound and a carbamate compound is carried out to synthesize a ?-aminoketone, a salt or a hydrate salt of a transition metal of Groups 7 to 11 of the Periodic Table of Elements being present in the reaction system as the catalyst. The novel method and the catalyst are capable of synthesizing the ?-aminoketone by the Aza-Michael reaction with high yield and efficiency.

Abstract: A carrier for carrying an osmium oxide comprising an aromatic polyolefin polymer having a group shown by the general formula [1] as a substituent on the aromatic ring of said polyolefin polymer: —A?—O(—A—O)n—R[1] (wherein A is an alkylene group; A? is a direct link or an alkylene group; R is an aryl group; and n is an integer of 1 to 10), an osmium oxide carried by the carrier for carrying an osmium oxide and a method for producing the osmium oxide carried by said carrier are disclosed. Since the osmium oxide carried by the carrier of the present invention has a hydrophilic group, in an oxidation reaction and an asymmetric oxidation reaction, particularly in a heterogeneous solvent system, the osmium oxide carried by the carrier of the present invention enables to produce a diol compound easily and in a high optical yield.

Abstract: Polymer-immobilized form amides characterized by being represented by the general formula: (wherein R1 is an optionally substituted hydrocarbon chain which may have a cyclic moiety or a heteroatom; R2 is an optionally substituted hydrocarbon group or an optionally substituted hydrocarbon chain which is bonded to R1 to form a ring; and the solid circle represents a polymer); novel organic catalysts containing the same, which catalysts are free from metallic catalyst components and very easy of recovery from reaction mixtures of synthesis and reuse; polymer-immobilized organic compounds useful as intermediates for synthesis; catalysts containing the same as the active ingredient; and a process for the allylation of aldehydes or hydrazones by the use of these catalysts.

Abstract: The present invention discloses 1) a catalyst composition consisting of a crosslinked organic polymer compound and a palladium catalyst, wherein said catalyst is physically carried on said crosslinked organic polymer compound, 2) a manufacturing method of the above catalyst composition 1), characterized by homogenizing a straight chain organic polymer compound, having a crosslinkable functional group, and a palladium catalyst in a solvent dissolving said straight chain organic polymer compound, then depositing a composition thus formed and subjecting the crosslinkable functional group in said deposit to a crosslinking reaction, 3) a method for substitution reaction at an allyl position, characterized by reacting an allyl carbonate and a neucleophilic agent in the presence of the above catalyst composition 1), and 4) a method for oxidizing an alcohol, characterized by subjecting the above catalyst composition 1) to reaction with an alcohol.

Abstract: An anilide is reacted with an acylating agent by using as a catalyst a tri(perfluoroalkane sulfonate) compound of any of the elements belonging to groups 3 to 5 and groups 13 to 15 in periods 4 to 6 of the periodic table, thereby bonding an acyl group to the benzene ring. Thus, ketoaniline derivatives, which are useful as physiologically active compounds or intermediates in synthesizing the same, are synthesized in high reaction yield by catalytic acylation.