Patents by Inventor Shu S. Yang

Shu S. Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1,3-diaryl cyclopentanes and derivatives thereof as PAF antagonists
    Patent number: 5132463
    Abstract: Novel 1,3-Diaryl cyclopentanes of the following general formula were prepared. ##STR1## These compounds were found to have potent and specific PAF (Platelet Activating Factor) antagonistic activities and as such useful in the treatment or amelioration of various diseases or disorders mediated by the PAF, for example, hypotension, inflammation, nephritis, stroke and other cardiovascular disorders, asthma, allergic and skin diseases, peptic or stomach ulcer, shock, lung edema, psoriasis, adult respiratory distress syndrome, pain including dental pain, and aggregation of platelets.
    Type: Grant
    Filed: June 12, 1991
    Date of Patent: July 21, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Donald W. Graham, John C. Chabala, Tesfaye Biftu, Michael N. Chang, Yuan-Ching P. Chiang, Shu S. Yang, Kathryn L. Thompson
  • Beta-lactams as antihypercholesterolemics
    Patent number: 5120729
    Abstract: This application relates to compounds of formula (I), which are useful as antihypercholesterolemic agents.
    Type: Grant
    Filed: June 20, 1990
    Date of Patent: June 9, 1992
    Assignee: Merck & Co., Inc.
    Inventors: John C. Chabala, Michael N. Chang, Yuan-Ching P. Chiang, James V. Heck, Kathryn L. Thompson, Shu S. Yang
  • 1,3-diaryl cyclopentanes and derivatives thereof as PAF antagonists
    Patent number: 5047420
    Abstract: Novel 1,3-diaryl cyclopentanes of the following general formula were prepared. ##STR1## These compounds were found to have potent and specific PAF (Platelet Activating Factor) antagonistic activities and as such useful in the treatment or amelioration of various diseases or disorders mediate by the PAF, for example, hypotension, inflammation, nephritis, stroke and other cardiovascular disorders, asthma, allergic and skin diseases, peptic or stomach ulcer, shock, lung edema, psoriasis, adult respiratory distress syndrome, pain including dental pain, and aggregation of platelets.
    Type: Grant
    Filed: August 21, 1989
    Date of Patent: September 10, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Donald W. Graham, Tesfaye Biftu, John C. Chabala, Michael N. Chang, Yuan-Ching P. Chiang, Kathryn L. Thompson, Shu S. Yang
  • Beta-lactams as anticholesterolemic agents
    Patent number: 4983597
    Abstract: Compounds of formula (I), which are useful as antihypercholesterolemic agents, are disclosed.
    Type: Grant
    Filed: August 31, 1989
    Date of Patent: January 8, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Shu S. Yang, Yuan-Ching P. Chiang, James V. Heck, Michael N. Chang
  • Acetylenic cyclic carbonates
    Patent number: 4920106
    Abstract: This invention relates to acetylenic cyclic carbonates that are useful in the treatment of fungal diseases and hypercholesterolemic conditions.
    Type: Grant
    Filed: August 1, 1989
    Date of Patent: April 24, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Michael N. Chang, Yuan-Ching P. Chiang, James V. Heck, Michael D. Lewis, Shu S. Yang
  • Antihypercholesterolemic .beta.-lactones
    Patent number: 4847271
    Abstract: The compounds of the following general structural formula (I) ##STR1## are 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase inhibitors and useful as antihypercholesterolemic agents for the treatment of disease in which the inhibition of cholesterol biosynthesis would be useful, such as arteriosclerosis, hyperlipidemia and familial hypercholesterolemia.
    Type: Grant
    Filed: March 4, 1987
    Date of Patent: July 11, 1989
    Assignee: Merck & Co., Inc.
    Inventors: John C. Chabala, Yuan-Ching P. Chiang, Michael N. Chang, Narindar M. Girotra, Donald W. Graham, Shu S. Yang
  • Antihypercholesterolemic .beta.-lactones
    Patent number: 4816477
    Abstract: The compounds of the following structural formula (I) ##STR1## ar 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase inhibitors and useful as antihypercholesterolemic agents for the treatment of disease in which the inhibition of cholesterol biosynthesis would be useful, such as arteriosclerosis, hyperlipidemia and familial hypercholesterolemia.
    Type: Grant
    Filed: May 26, 1987
    Date of Patent: March 28, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Narindar N. Girotra, Shu S. Yang, Donald W. Graham
  • Antihypercholesterolemic beta-lactones
    Patent number: 4806564
    Abstract: The compounds of the following structural formula (I) ##STR1## are 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase inhibitors and useful as antihypercholesterolemic agents for the treatmet of disease in which the inhibition of cholesterol biosynthesis would be useful, such as arteriosclerosis, hyperlipidemia and familial hypercholesterolemia.
    Type: Grant
    Filed: May 26, 1987
    Date of Patent: February 21, 1989
    Assignee: Merck & Co., Inc.
    Inventors: John C. Chabala, Yuan-Ching P. Chiang, Michael N. Chang, Donald W. Graham, James V. Heck, Shu S. Yang
  • Indene derivatives and their use as PAF-antagonists
    Patent number: 4656190
    Abstract: Indene derivatives have been found to have potent and specific PAF (Platelet-Activating-Factor) antagonistic activities and are thereby useful in the treatment of various diseases or disorders mediated by the PAF, for example, inflammation, cardiovascular disorder, asthma, lung edema, and adult respiratory distress syndrome.
    Type: Grant
    Filed: November 14, 1983
    Date of Patent: April 7, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Tsung-Ying Shen, Shu S. Yang, San-Bao Hwang
  • Phosphatidyl inositol analogs useful as anti-inflammatory/analgesic agents
    Patent number: 4515722
    Abstract: Phosphatidyl inositol analogs are found to be effective phospholipase C inhibitors and thereby potent anti-inflammatory and analgesic agents. These phosphatidyl inositol analogs are prepared by condensation of a protected inositol with a substituted phosphonic or phosphorous acid followed by removal of protecting groups.
    Type: Grant
    Filed: March 30, 1982
    Date of Patent: May 7, 1985
    Assignee: Merck & Co., Inc.
    Inventors: Shu S. Yang, Thomas R. Beattie, Philippe L. Durette, Timothy F. Gallagher, Tsung-Ying Shen
  • Sulfonyl or carbonyl inositol derivatives useful as anti-inflammatory/analgesic agents
    Patent number: 4474806
    Abstract: Sulfonyl or carbonyl derivatives of inositols are found to be effective phospholipase C inhibitors and thereby potent anti-inflammatory and analgesic agents. These inositol derivatives are prepared by condensation of a protected inositol with a substituted sulfonic or carboxylic acid derivative followed by removal of protecting groups.
    Type: Grant
    Filed: May 10, 1982
    Date of Patent: October 2, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Thomas R. Beattie, Shu S. Yang
  • Peptide carbazates and pharmaceutical composition
    Patent number: 4064236
    Abstract: Certain novel peptide carbazates, their preparation, pharmaceutical compositions and novel methods of treating pancreatitis.
    Type: Grant
    Filed: December 23, 1975
    Date of Patent: December 20, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Conrad P. Dorn, Shu S. Yang
  • Peptide carbazates
    Patent number: 4029772
    Abstract: Certain novel peptide carbazates, their preparation, pharmaceutical compositions and novel methods of treating pancreatitis.
    Type: Grant
    Filed: December 23, 1975
    Date of Patent: June 14, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Conrad P. Dorn, Shu S. Yang