Abstract: The present disclosure provides a method for selecting a drug candidate for treating or preventing or delaying the onset or progression of an amyloidogenic disease, comprising: (a) contacting an analyte with amyloid peptide 1-42 (A?42) and an amphiphilic liposaccharide or a part thereof, wherein the amphiphilic liposaccharide or the part thereof is capable of forming a complex with A?42; and (b) determining if the analyte extends an oscillatory event of the complex; and the analyte is selected as the drug candidate.

Abstract: A new process to synthesis of compound OBI-3424 R-form and S-form products is provided. The “R-form” compound OBI-3423 was first synthesized with 48% overall yield from compound OBI-3424-5 by installation of the labile phosphate motif at later stage. The stereo chemistry is established by 5 steps chemo-enzyme combination synthesis to afford 99% optical purity. After then, the “S-form” compound OBI-3424 is prepared with improving overall yield of 54% from compound OBI-3424-5. The stereo chemistry is established by 4 steps combination of chemo-enzyme synthesis with excellent optical purity of 99%.

Abstract: The present disclosure encompasses immunogenic/therapeutic compositions including Globo series antigens (SSEA-4, Globo H or SSEA-3) glycoconjugates and therapeutic adjuvants (OBI-821 or OBI-834) as well as methods of making and using the same to treat proliferative diseases such as cancer. The therapeutic conjugates include an antigen linked to a carrier. In particular, the therapeutic conjugates include a SSEA-4, Globo H or SSEA-3 moiety and a KLH moiety subunit linked via a linker. The therapeutic compositions are in part envisaged to act as cancer vaccines (single valent, bi-valent or tri-valent vaccines) for boosting the body's natural ability to protect itself, through the immune system from dangers posed by damaged or abnormal cells such as cancer cells. Exemplary immune response can be characterized by reduction of the severity of disease, including but not limited to, prevention of disease, delay in onset of disease, decreased severity of symptoms, decreased morbidity and delayed mortality.

Abstract: The present disclosure relates to a method for treating or preventing or delaying the onset or progression of an amyloidogenic disease in a subject in need, comprising administering a pharmaceutical composition comprising a therapeutically effective amount of amphiphilic liposaccharide to the subject. The present disclosure also relates to a method for selecting an agent for treating or preventing or delaying the onset or progression of an amyloidogenic disease and a novel liposaccharide.

Abstract: A new process to synthesis of compound OBI-3424 R-form and S-form products is provided. The “R-form” compound OBI-3423 was first synthesized with 48% overall yield from compound OBI-3424-5 by installation of the labile phosphate motif at later stage. The stereo chemistry is established by 5 steps chemo-enzyme combination synthesis to afford 99% optical purity. After then, the “S-form” compound OBI-3424 is prepared with improving overall yield of 54% from compound OBI-3424-5. The stereo chemistry is established by 4 steps combination of chemo-enzyme synthesis with excellent optical purity of 99%.

Abstract: Antibody drug conjugates (ADC's) comprising a drug moiety/payload conjugated to antibody or antigen binding fragments thereof that bind to Globo series antigen disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as sarcoma, skin cancer, leukemia, lymphoma, brain cancer, glioblastoma, lung cancer, breast cancer, oral cancer, head-and-neck cancer, nasopharyngeal cancer, esophagus cancer, stomach cancer, liver cancer, bile duct cancer, gallbladder cancer, bladder cancer, pancreatic cancer, intestinal cancer, colorectal cancer, kidney cancer, cervix cancer, endometrial cancer, ovarian cancer, testical cancer, buccal cancer, oropharyngeal cancer, laryngeal cancer and prostate cancer.

Abstract: A sub-nanometer gold sticker for blocking efficiently endotoxin activity to protect against sepsis is disclosed. The sub-nanometer gold sticker comprises a gold nanocluster that serves as a flake-like substrate and a coating of short alkyl motifs that act as an adhesive, allowing the sub-nanometer gold sticker to dock with LPS by compacting the intramolecular hydrocarbon chain-chain distance (d-spacing) of lipid A, an endotoxicity active site that can cause overwhelming cytokine induction resulting in sepsis progression. Methods of blocking endotoxin activity, and suppressing pro-inflammatory cytokines are also disclosed. Also disclosed is a method of protecting against endotoxin-induced sepsis via increasing critical micelle concentration for the inhibition of LPS non-lamellar aggregation.

Abstract: The invention relates to linkers and methods for generating arrays with linkers. The invention also relates to methods for identifying agents that bind to various types of molecules on the arrays and to defining the structural elements of the molecules on the arrays that bind to those agents. The arrays and methods provided herein may be used for epitope identification, drug discovery and as analytical tools. The invention provides useful glycans and epitope determinants that are useful in detecting, diagnosing, recurrence monitoring and preventing cancer.

Abstract: The present disclosure encompasses immunogenic/therapeutic compositions including Globo series antigens (SSEA-4, Globo H or SSEA-3) glycoconjugates and therapeutic adjuvants (OBI-821 or OBI-834) as well as methods of making and using the same to treat proliferative diseases such as cancer. The therapeutic conjugates include an antigen linked to a carrier. In particular, the therapeutic conjugates include a SSEA-4, Globo H or SSEA-3 moiety and a KLH moiety subunit linked via a linker. The therapeutic compositions are in part envisaged to act as cancer vaccines (single valent, bi-valent or tri-valent vaccines) for boosting the body's natural ability to protect itself, through the immune system from dangers posed by damaged or abnormal cells such as cancer cells. Exemplary immune response can be characterized by reduction of the severity of disease, including but not limited to, prevention of disease, delay in onset of disease, decreased severity of symptoms, decreased morbidity and delayed mortality.

Abstract: An endotoxin nanovesicle for enhancing type 1 T helper cell-induced immunological responses is disclosed. The endotoxin nanovesicle comprises: (a) lipopolysaccharide molecules, assembled into a vesicle with a wall surrounding an inner space; and (b) hydrophilic gold nanodots, localized in the wall of the vesicle. Methods of suppressing formation of cubosomes and/or hexosomes in lipopolysaccharide aggregation or assembly, and methods of preparing a lipopolysaccharide adjuvant are also disclosed. Also disclosed are compositions comprising an endotoxin aggregate or an endotoxin nanoversicle and optionally an immunogenic antigen.

Abstract: The invention relates to linkers and methods for generating arrays with linkers. The invention also relates to methods for identifying agents that bind to various types of molecules on the arrays and to defining the structural elements of the molecules on the arrays that bind to those agents. The arrays and methods provided herein may be used for epitope identification, drug discovery and as analytical tools. The invention provides useful glycans and epitope determinants that are useful in detecting, diagnosing, recurrence monitoring and preventing cancer.

Abstract: A method for writing update data into a flash memory module to replace original data is provided. The flash memory module includes at least one block including a plurality of sectors. Each of the sectors records a flag. The data storing method includes: getting a first sector, wherein all the bits of the flag of the first sector are the second storage status; writing the update data into the first sector, and programming at least one bit as the first storage status and at least one bit as the second storage status in the flag of the first sector; identifying a second sector storing original data, wherein at least one bit of the flag of the second sector is first storage status and at least one other bit is second storage status; programming all the bits of the second sector as the first storage status.

Abstract: The present disclosure provides a data storing method for writing update data into a flash memory module to replace original data. The flash memory module includes at least one block including a plurality of sectors. Each of the sectors records a flag. The data storing method includes: getting a first sector, wherein all the bits of the flag of the first sector are the second storage status; writing the update data into the first sector, and programming at least one bit as the first storage status and at least one bit as the second storage status in the flag of the first sector; identifying a second sector storing original data, wherein at least one bit of the flag of the second sector is first storage status and at least one other bit is second storage status; programming all the bits of the second sector as the first storage status.

Abstract: A caged platinum nanocluster complex is disclosed. The complex comprises (a) an amine-terminated dendrimer; and (b) a platinum nanocluster comprising platinum oxides, the platinum nanocluster being confined inside of the amine-terminated dendrimer. The complex exhibits cytotoxicity to cancer cells. A double-caged platinum nanocluster complex is also disclosed, which comprises polyethylene glycol (PEG) coated on the surface of a dendrimer caged platinum nanocluster complex. The double-caged caged platinum nanocluster complex comprises pH-sensitive bonds on the surface thereof. Also disclosed are methods of preparing and using the same.

Abstract: A robot includes a storage unit, a receiving unit, a central control unit, and an implementation unit. The storage unit is used for storing a body motion script database. The receiving unit is used for receiving a sound signal. The central control unit is used for outputting a motion arrangement description file according to the messages of the sound signal, reading a corresponding body motion script from the body motion script database according to the motion arrangement description file, and generating a motion arrangement command according to the body motion script. The implementation unit includes a control circuit and a driving device. The control circuit is used for generating a control signal in response to the motion arrangement command. According to the control signal, the driving device is controlled to drive at least one moving part of the robot to generate a corresponding body motion according to the sound signal.

Abstract: A caged platinum nanocluster complex is disclosed. The complex comprises (a) an amine-terminated dendrimer; and (b) a platinum nanocluster comprising platinum oxides, the platinum nanocluster being confined inside of the amine-terminated dendrimer. The complex exhibits cytotoxicity to cancer cells. A double-caged platinum nanocluster complex is also disclosed, which comprises polyethylene glycol (PEG) coated on the surface of a dendrimer caged platinum nanocluster complex. The double-caged caged platinum nanocluster complex comprises pH-sensitive bonds on the surface thereof. Also disclosed are methods of preparing and using the same.

Abstract: An internet phone integrating system includes a PC, a VoIP phone, a softphone, an HID signal-transmitting unit, and a media transmitting unit. The VoIP phone provides an HID inputting signal. The softphone provides an HID outputting signal and a media controlling signal and decodes an audio coding streaming to a media data flow. The HID signal-transmitting unit receives the HID outputting signal from the softphone and sends the HID outputting signal to the VoIP phone, and receives the HID inputting signal from the VoIP phone and sends the HID inputting signal to the softphone. The media transmitting unit receives the media controlling signal and media data flow from the softphone and sends the media controlling signal and media data flow to the VoIP phone, and receives the media data flow from the VoIP phone and sends the media data flow to the softphone.

Abstract: A method of synthesizing a random copolymer of polyethyleneimine and polyethylene glycol, comprising exposing ethanolamine in a solution to electromagnetic radiation for a sufficient time to polymerize the ethanolamine (OHCH2CH2NH2) and thereby resulting in formation of the randome copolymer comprising polyethyleneimine and poly(ethylene glycol), wherein the polyethyleneimine comprises ethyleneimine (—CH2CH2NH—) unit and the polyethylene glycol comprises ethylene glycol (—CH2CH2O—) unit, and the polyethylenimine of the random copolymer has a substantially linear backbone.

Abstract: The present invention provides a method for estimating a capacity usage status of a storage unit, where the storage unit includes a plurality of sectors. The method includes: estimating capacity usage statuses of a portion of sectors; and utilizing a controller to estimate the capacity usage status of the storage unit according to the estimated capacity usage statuses of the portion of sectors in a situation of not estimating capacity usage statuses of all of the sectors of the storage unit.

Abstract: A method of synthesizing a random copolymer of polyethyleneimine and polyethylene glycol, comprising exposing ethanolamine in a solution to electromagnetic radiation for a sufficient time to polymerize the ethanolamine (OHCH2CH2NH2) and thereby resulting in formation of the randome copolymer comprising polyethyleneimine and poly(ethylene glycol), wherein the polyethyleneimine comprises ethyleneimine (—CH2CH2NH—) unit and the polyethylene glycol comprises ethylene glycol (—CH2CH2O—) unit, and the polyethylenimine of the random copolymer has a substantially linear backbone.