Abstract: Disclosed herein are humanized antibodies, antigen-binding fragments thereof, and antibody conjugates, that are capable of specifically binding to certain biantennary Lewis antigens, which antigens are expressed in a variety of cancers. The presently disclosed antibodies are useful to target antigen-expressing cells for treatment or detection of disease, including various cancers. Also provided are polynucleotides, vectors, and host cells for producing the disclosed antibodies and antigen-binding fragments thereof. Pharmaceutical compositions, methods of treatment and detection, and uses of the antibodies, antigen-binding fragments, antibody conjugates, and compositions are also provided.

Abstract: An optical mouse system with a high-angle optical path features small size and low power consumption. The illumination source and optical sensor are mounted in the same plane, directly on the PCB. The higher angle of the optical path causes more light to be reflected to the optical sensor, increasing optical efficiency and allowing a smaller, lower powered LED to be used. This also results in increased sensitivity of the optical sensor, allowing use of the mouse on surfaces on which conventional optical mice cannot function adequately. Sensitivity can be further increased by optional isolation of the optical sensor and illumination source. Lower power usage increases battery life for mobile or wireless-mouse use, while reducing thermal waste considerations. This allows the creation of a significantly smaller form factor for the overall package, thereby reducing materials costs and giving designers more flexibility for external design considerations.