Abstract: Disclosed are a pixel circuit, a driving method thereof, and a display apparatus. The pixel circuit includes a driving sub-circuit, a writing sub-circuit, a compensation sub-circuit, a reset sub-circuit, and a light-emitting element, the driving sub-circuit provides a driving current to a third node in response to a control signal of a first node; the writing sub-circuit writes a signal of a data signal line to a second node in response to a control signal of a first scan signal line, the signal of the data signal line is a data voltage signal or a reset voltage signal; the compensation sub-circuit writes the reset voltage signal to the third node in response to a control signal of the first scan signal line; the compensation sub-circuit further compensates the first node in response to a control signal of the first scan signal line.

Abstract: An intelligent smog-penetrating optical imaging detection device and a method of thereof, and belongs to the technical field of photoelectric imaging. The intensity information, the spectrum information, and the polarization information of light are organically combined, the three functions of intensity imaging, spectrum imaging and polarization imaging can be achieved, traditional imaging detection is beneficially supplemented, smog can be penetrated, the image contrast of imaging is improved, and therefore the working distance is increased. The intensity information reflects the detection distance, the target shape, the target size and the like; the spectrum information reflects material components, surface morphology and the like of a space target; the polarization information reflects the material and roughness of the target and the contrast with the background; and the intensity, spectrum and polarization three-dimensional information is jointly applied, the image contrast can be increased by 2-3 times.

Abstract: The present disclosure provides methods of protecting ribonucleic acid (RNA) from degradation under certain conditions by contacting the RNA with an amino acid. The present disclosure also provides compositions comprising such amino acid(s) and RNA.

Abstract: This disclosure provides an array substrate and a display device. In the array substrate, the pixel driving circuit includes a driving transistor, a first transistor and a second transistor. The driving transistor and the first transistor are P-type transistors, and the second transistor is N-type transistor. The array substrate also includes a base substrate, and a first conductive layer arranged at a side of the base substrate and including: a first conductive portion forming a gate electrode of the driving transistor; a first gate line at a side of the first conductive portion, a part of the first gate line being configured to form a gate electrode of the first transistor; and a second gate line at a side of the first gate line away from the first conductive portion, a part of the second gate line being configured to form a first gate electrode of the second transistor.

Abstract: The present invention relates to a preparation and purification method for cationic quaternary ammonium salt of sodium hyaluronate in homogeneous medium. By adding a homogeneous solvent and a sodium hyaluronate solid to a vessel, heating the vessel until the contents are dissolved to form a homogeneous system, adding an aqueous solution of 2,3-epoxypropyltrimethylammonium chloride (GTA) to the homogeneous system, then adding a base catalyst, and stirring at a preset temperature to carry out a graft reaction, a graft product is obtained wherein 2,3-epoxypropyltrimethylammonium chloride is grafted to the oxygen atom of the hydroxymethyl group of sodium hyaluronate. By using the method, a graft product wherein 2,3-epoxypropyltrimethylammonium chloride is grafted to the oxygen atom of the hydroxymethyl group of sodium hyaluronate is obtained. Addition of salts is avoided during the reaction, a grafting yield up to 0.69 is obtained, and coagulation occurred to the product is effectively solved.

Abstract: The present invention provides formulations of anti-LAG3 antibodies, and co-formulations of anti-PD-1 antibodies and anti-LAG3 antibodies, and their use in treating various disorders.

Abstract: The present invention provides formulations of anti-LAG3 antibodies, and co-formulations of anti-PD-1 antibodies and anti-LAG3 antibodies, and their use in treating various disorders.

Abstract: The present invention provides a heat-resistant cast steel, and a preparation method and use thereof. Based on the total mass of the heat-resistant cast steel, the heat-resistant cast steel includes the following elements in mass percentage: 0.08 wt %-0.18 wt % of C, 0.10 wt %-0.40 wt % of Si, 0.30 wt %-0.70 wt % of Mn, 9.80 wt %-10.70 wt % of Cr, 3.00 wt %-3.50 wt % of Co, 1.60 wt %-2.00 wt % of W, 0.45 wt %-0.85 wt % of Mo, 0.10 wt %-0.30 wt % of V, 0.02 wt %-0.08 wt % of Nb, 0.010 wt %-0.035 wt % of N, 0.001 wt %-0.010 wt % of B, <0.20 wt % of Ni and 79 wt %-85.5 wt % of Fe. The heat-resistant cast steel can satisfy the use requirements of turbine parts with a working temperature of 635° C. and below 635° C.

Abstract: This disclosure relates to stable aqueous pharmaceutical formulations comprising a therapeutically effective amount of an incretin-insulin conjugate as well as methods of using the same, and aqueous pharmaceutical formulations containing an incretin-insulin conjugate which are stable and which provide a protracted pharmacodynamics profile, which include L-arginine HCl and phenol (or m-cresol) as stabilizing agents. The invention also provide a method of treating a patient or individual having a metabolic disease, comprising administering to the patient or individual an effective amount of any of the aqueous pharmaceutical formulations described herein.

Abstract: A network standard switching method includes obtaining a network standard switching instruction including a target priority. The network standard switching instruction instructs a terminal device to be handed over to a target network whose standard is a target standard, and a priority of the target network is greater than a priority of a network in which the terminal device is currently located. The method further includes releasing a network link between the terminal device and a currently accessed first base station, intercepting and caching to-be-sent application-layer data of the terminal device, discarding a paging message in a packet switched (PS) domain received from a first-priority network to the terminal device, and handing over to the target network.

Abstract: A network fault handling method and device, the method including obtaining a first data amount of uplink data sent by a terminal device within preset duration, obtaining a second data amount of downlink packet data received by the terminal device within the preset duration, and performing, in response to determining that the first data amount is greater than a first threshold and the second data amount is equal to 0, at least one of re-establishing a radio resource control (RRC) connection or re-obtaining an Internet Protocol (IP) connection resource.

Abstract: Embodiments relate to a signaling processing method and user equipment. The signaling processing method includes: measuring a received signal level of user equipment with respect to a current cell, determining a camping parameter of the user equipment with respect to the cell according to the received signal level, making compensation for the camping parameter, and determining that the user equipment camps on the cell if the camping parameter after compensation is greater than a preset camping threshold.

Abstract: This disclosure relates to stable aqueous pharmaceutical formulations comprising a therapeutically effective amount of an incretin-insulin conjugate as well as methods of using the same, and aqueous pharmaceutical formulations containing an incretin-insulin conjugate which are stable and which provide a protracted pharmacodynamics profile, which include L-arginine HCl and phenol (or m-cresol) as stabilizing agents.

Abstract: A network fault handling method and device, the method including obtaining a first data amount of uplink data sent by a terminal device within preset duration, obtaining a second data amount of downlink packet data received by the terminal device within the preset duration, and performing, in response to determining that the first data amount is greater than a first threshold and the second data amount is equal to 0, at least one of re-establishing a radio resource control (RRC) connection or re-obtaining an Internet Protocol (IP) connection resource.

Abstract: The present invention provides formulations of anti-LAG3 antibodies, and co-formulations of anti-PD-1 antibodies and anti-LAG3 antibodies, and their use in treating various disorders.

Abstract: The present invention provides a method for simulating magnetic flux leakage based on loop current, the magnetic distribution of a single loop current is obtained by solid angle, then the magnetic field distribution of a semi-infinite solenoid is obtained based on the assumption of arrangement of loop currents in the magnetized specimen, and its equation is given; and the JA hysteresis model is introduced to obtain the distribution of quasi-static magnetic flux leakage field, on the basis of analyzing the relation between the distribution of a loop current on the surface of the defect and the excitation magnetic field, the distribution of quasi-static magnetic flux leakage field is obtained based on the semi-infinite solenoid.

Abstract: A network standard switching method includes obtaining a network standard switching instruction including a target priority. The network standard switching instruction instructs a terminal device to be handed over to a target network whose standard is a target standard, and a priority of the target network is greater than a priority of a network in which the terminal device is currently located. The method further includes releasing a network link between the terminal device and a currently accessed first base station, intercepting and caching to-be-sent application-layer data of the terminal device, discarding a paging message in a packet switched (PS) domain received from a first-priority network to the terminal device, and handing over to the target network.

Abstract: The present invention provides a method for simulating magnetic flux leakage based on loop current, the magnetic distribution of a single loop current is obtained by solid angle, then the magnetic field distribution of a semi-infinite solenoid is obtained based on the assumption of arrangement of loop currents in the magnetized specimen, and its equation is given; and the JA hysteresis model is introduced to obtain the distribution of quasi-static magnetic flux leakage field, on the basis of analyzing the relation between the distribution of a loop current on the surface of the defect and the excitation magnetic field, the distribution of quasi-static magnetic flux leakage field is obtained based on the semi-infinite solenoid.

Abstract: Disclosed is a pharmaceutical formulation comprising an insulin or insulin analog molecule covalently attached to at least one branched linker having a first arm and second arm, wherein the first arm is linked to a first ligand that includes a first saccharide and the second arm is linked to a second ligand that includes a second saccharide and wherein the first saccharide is fucose suitable for parenteral or subcutaneous administration and which is suitable for use in controlling post-prandial glucose levels in an individual.

Abstract: Disclosed is a pharmaceutical formulation comprising an insulin or insulin analog molecule covalently attached to at least one branched linker having a first arm and second arm, wherein the first arm is linked to a first ligand that includes a first saccharide and the second arm is linked to a second ligand that includes a second saccharide and wherein the first saccharide is fucose. The formulation is suitable for subcutaneous administration and provides a basal pharmacodynamic profile for the insulin oligosaccharide conjugate.