Abstract: A handheld system of automatic acupoint stimulation has a case, a camera unit, a storage unit, a human-machine-interface (HMI) unit, a processing unit, an acupoint recognizing unit, and an acupoint stimulating unit. The case has an accommodating space and a handle portion. The camera unit is to capture an image from a body part of a user. The storage unit is to store multiple predetermined acupoint data. The HMI unit is to receive an input signal. The processing unit searches for at least one predetermined acupoint datum that is corresponding to the input signal. The acupoint recognizing unit is to receive the at least one predetermined acupoint datum and obtain a reference length and a beginning basis to locate the acupoint. The acupoint stimulating unit is to stimulate the acupoint of the user located by the acupoint recognizing unit.