Abstract: Salts and crystalline forms of 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}-sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide are suitable active pharmaceutical ingredients for pharmaceutical compositions useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

Abstract: A system is for estimating a remaining lifetime of an aldehyde filter. The system comprises aa aldehyde filter (14) through which at least a portion of the gas is to be passed for removing aldehyde (10) from the gas (12) and a detecting medium (16) through which at least a portion of the gas is to be passed comprising photoluminescent carbon-based dots (18), a light source for emitting an excitation light (E) through the detecting medium for exciting the carbon-based dots which thereby emit luminescent light (L), a detector (28) for detecting the luminescent light (L), the luminescent light (L) having a luminescence property; and a controller (30) for determining information relating to intensity of a red, a green or a blue component of the luminescence property and estimating a remaining lifetime of the aldehyde filter from the determined information.

Abstract: The invention provides a system for determining a risk level of a pollen-induced allergy of a user. The system comprises an input for receiving information relating to a pollen level in a location, an input for receiving information relating to a particulate matter level in the location and an input for receiving information relating to a sensitivity of a user to pollen allergen. The system further comprises a processor which is adapted to determine the risk level by taking account of the information relating to a pollen level, the information relating to a particulate matter level and the information relating to a sensitivity of the user to pollen allergen. A user interlace communicates the risk level in the location to the user.

Abstract: A particle sensing apparatus is provided for determining particle concentration in a fluid, e.g. air. The apparatus is based on fluid-flow passageway having an upstream inlet to receive the fluid and a downstream outlet to exhaust the fluid. It also includes a recirculation passageway in fluid communication with the fluid-flow passageway. Between them, the fluid-flow passageway and the recirculation passageway define a recirculation loop. A first particle sensor is located in the recirculation loop, and other sensors may also be present at other options. A force applicator is included in the fluid-flow passageway to apply a force to the particles entrained in the fluid. The force is used to direct some or all of the particles into the recirculation loop. This provides a choice between increasing the detection limit or the detection range. A processor determines the concentration of particles in the fluid based on the concentration of particles detected at the first particle sensor.

Abstract: A borate compound serving as a proteasome inhibitor, a preparation method for the borate compound and uses thereof.

Abstract: In one general aspect, a method for rendering a web page can include receiving, from an interactive web application executing on a computing device, a plurality of application programming interface (API) calls for information and data for including in the rendering of the web page by the interactive web application, determining, for each of the plurality of API calls, whether an API call satisfies at least one criterion, storing, in a memory included on a computing device, an API call for inclusion in a batch of API calls if the API call satisfies the at least one criterion, and sending, in a single API call, the batch of API calls stored in the memory, the sending based on an occurrence of an event in the computing device.

Abstract: A particle sensing system is for sensing particles entrained in a fluid. The system comprises a flow channel having a longitudinal direction along which the fluid is to be passed, a heating arrangement for heating the fluid and thereby applying a positive thermophoretic force on the fluid in a direction perpendicular to the longitudinal direction of the flow channel and a first sensor for sensing the particles in the fluid after heating by the heating arrangement. The thermophoretic force increases the concentration of the particles at the first sensor.

Abstract: A wireless earphone comprising an in-ear portion which is in contact with a human ear when the wireless earphone is worn. The in-ear portion comprises a wearing surface which couples the human ear canal when the wireless earphone is worn. The in-ear portion is provided with a wearing detection sensor, a sound venting hole and a contact group which are all disposed on the wearing surface. The wearing detection sensor, the sound venting hole and the contact group are all disposed on the wearing surface of the in-ear portion coupling the human ear canal, so that the wearing detection sensor can directly contact the skin of the human body when the earphone is worn, and thus the wearing detection sensor is improved.

Abstract: Provided herein are methods for reserving a parking space. In a user-implemented method, a user inputs a request into an electronic device to reserve one or more parking spaces and pays for the reservation. The reservation may be for a general parking space or for a specific parking space in a parking lot or garage. In another method the user inquiry is received as input and processed on an electronic device networked to a central cloud server comprising a distributed cloud computer system. A status of the parking space is displayed to the user in real time to which the user makes a reply. Also provided is a distributed e-parking space system able to execute instructions to receive input and, via a Distributed Internet Services system, to distribute an application or components to process input, deploy the distributed applications/components and synchronize data related to the reservation process.

Abstract: An apparatus is provided for determining particle characteristics, in which a flow path is generated containing particles to be analyzed. A light detection system detecting light received from a measurement zone which has been scattered by the particles. A time duration for which a particle remains in the measurement zone is measured to determine an effective aerodynamic particle diameter and a peak detected received light intensity is measured to determine an effective optical particle diameter. A further particle parameter is also obtained relating to the shape and/or density of the particle. This approach enables more information than only a particle size to be obtained using a single-stage optical analysis system. The additional information may be used to characterize the particles more accurately.

Abstract: An infrared automobile charging system includes: a photovoltaic battery panel installed at a bottom of a vehicle; a camera module; a first actuating device connected with the camera module; an infrared light source; a second actuating device connected with the infrared light source; and a controller being connected with the camera module, the first actuating device, the infrared light source and the second actuating device. The controller is configured to control the first actuating device to rotate, and through the first actuating device control the camera module to capture a preset pattern disposed at the bottom of the vehicle. After the camera module has captured the preset pattern disposed at the bottom of the vehicle, the controller is configured to control the second actuating device to rotate accordingly so that the infrared light source projects infrared light to the photovoltaic battery panel and thereby charge the photovoltaic battery panel.

Abstract: The present invention is directed to hemostatic compositions comprising at least partially integrated agglomerated ORC fibers, fibrinogen, and thrombin and methods of forming a powdered hemostatic composition, comprising the steps of: forming a suspension of a mixture comprising particles of fibrinogen, thrombin, ORC fibers in a non-aqueous low boiling solvent, agitating and shearing said suspension in a high shear mixing reactor, adding water to allow particles to agglomerate, allowing the non-aqueous solvent to evaporate, drying and sieving the composition; and thus forming the powdered hemostatic composition.

Abstract: A filter element (1) for use in a gas purification device (100) is disclosed. It comprises a substrate (10) and a filter layer (20) covering an exterior surface of the substrate (10). The substrate (10) comprises material for containing chemicals (30) effective to remove gas pollutants from a gas. The material of the filter layer (20) is hydrophilic to adsorb liquid solution adsorbents effective in removing gas pollutants from a gas, and the exterior surface of the substrate (10) covered by the filter layer (20) is hydrophobic.

Abstract: Salts and crystalline forms of 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}-sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide are suitable active pharmaceutical ingredients for pharmaceutical compositions useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

Abstract: A computer system includes a course repository and a server. The course repository includes a video of an online course, an instructor provided output for a programming assignment associated with the online course, and a submission script for generating student provided output for the programming assignment. The server includes a submission module that receives and verifies the student provided output for the programming assignment. The server further includes one or more built-in grader applications that compare the student provided output with the instructor provided output to determine a grade for the programming assignment.

Abstract: An air purifier comprise a gas filter between an upstream air flow and a downstream air flow and a concentration sensor comprising a first electrode and a second electrode, the first electrode being exposed to the upstream air flow and the second electrode exposed to the downstream air flow, the concentration sensor providing an output signal based on the difference in concentrations of a target gas at the first and second electrodes. The output signal is processed to determine information relating to the con- dition of the gas filter.

Abstract: In one general aspect, a computer-implemented method can include receiving, by a computer system, code for a custom grader application, creating, by the computer system, a base custom grader container including the code for the custom grader application, associating the base custom grader container with an online course included in a repository included in the computer system, evaluating, by the computer system, the base custom grader container by executing the custom grader application in the base custom grader container, determining that the custom grader application violates a predetermined criterion, modifying the base custom grader container to prevent the executing of the custom grader application from violating the predetermined criterion, and storing, in the repository and in association with the online course, the modified base custom grader container including the custom grader application as a custom grader container image.

Abstract: Embodiments of the present invention relate to method and device for measuring optical signal-to-noise ratio (OSNR). A method for measuring an OSNR of a signal of interest may comprise: obtaining spectrum of the signal of interest, the spectrum including power spectrum density distribution of the signal of interest in a channel bandwidth B; obtaining spectrum of a comparative signal that has the same spectrum characteristics as but different OSNR than the signal of interest, the spectrum including power spectrum density distribution of the comparative signal in the channel bandwidth B; and calculating the OSNR of the signal of interest by using the spectrum of the signal of interest and the spectrum of a comparative signal.

Abstract: The invention describes a modular fluid sensing system comprising a fluid sensing terminal (150) and removable fluid channel units (101, 102, 103). The fluid channel units (101, 102, 103) comprise or can be combined with fluid treatment units as filters, sensors and seals. The fluid channel units (101, 102, 103) can be combined in accordance with the present needs of the user of the fluid sensing system. The invention therefore enables a reconfigurable channel system with reconfigurable measurement and treatment options within a fluid sensing system.

Abstract: Provided herein is a non-transitory computer readable medium comprising software configured to enable instructions to create of a multidimensional value model for an event, such as, a travel event. When executed information related to events from all sources is stored and categorized according to the source, value dimension and value description of the event are established and used to create an initial multidimensional value model. If the event is a travel event, the initial model is updated according to user-selected travel events and a recommendation for travel made to the user based on the updated model. Also provided is a distributed cloud computer system that integrates cloud computing with a Distributed Internet Services system and cloud computing methods, particularly, for improving user experience during e-commerce transactions. A non-transitory storage medium tangibly stores processor-executable instructions to execute the methods.