Abstract: A method of designing an integrated circuit (IC) device includes identifying, with a processor, a pin failing a test to determine an antenna effect, identifying, with the processor, a net corresponding to the identified pin failing the test to determine the antenna effect, and creating, with the processor, an engineering change order (ECO) script based on the identified net to insert a diode to address the antenna effect.

Abstract: The present application discloses an optical imaging lens, comprising, in order from an object side to an image side along an optical axis: a first lens having a positive refractive power; a second lens having a positive refractive power; a third lens having a negative refractive power; a fourth lens; a fifth lens having a negative refractive power; and a sixth lens having a positive refractive power, wherein a distance TTL from an object side surface of the first lens to an imaging plane of the optical imaging lens on the optical axis and an entrance pupil diameter EPD of the optical imaging lens satisfy TTL/EPD<1.9; and a total effective focal length f of the optical imaging lens satisfies 6.0 mm<f<7.5 mm.

Abstract: Recombinant Aspergillus genetically modified to increase expression of g8846, renamed herein as aconitic acid exporter (aexA), are provided, which in some examples are also genetically inactivated for an endogenous cis-aconitic acid decarboxylase (cadA) gene. Such recombinant Aspergillus produce more aconitic acid as compared to native Aspergillus. Also provided are methods of using such recombinant Aspergillus to increase production of aconitic acid and other organic acids, such as citric acid, itaconic acid, and 3-hydroxypropionic acid (3-HP).

Abstract: Provided in the present invention is a method for constructing a multispecific antibody. The method comprises the steps of: (i) constructing a first polynucleotide and a second polynucleotide, respectively, wherein the first polynucleotide and the second polynucleotide respectively encode a first polypeptide containing a CL region and a second polypeptide containing a CH1 region, and a disulfide bond may be formed between the CL region of the first polypeptide and the CH1 region of the second polypeptide, such that the antibody has a heterodimeric form; and (ii) expressing the first polynucleotide and the second polynucleotide to obtain the first polypeptide and the second polypeptide, and dimerize the first polypeptide and the second polypeptide to form a multispecific antibody with a heterodimeric form.

Abstract: A method of designing an integrated circuit (IC) device includes identifying, with a processor, a pin failing a test to determine an antenna effect, identifying, with the processor, a net corresponding to the identified pin failing the test to determine the antenna effect, and creating, with the processor, an engineering change order (ECO) script based on the identified net to insert a diode to address the antenna effect.