Abstract: A multi-target kinase inhibitor is shown in formula (I), in which R is selected from formula (a), formula (b), formula (c), formula (d), formula (e) and formula (f). The multi-target kinase inhibitor can effectively inhibit the enzymatic activities of RET, VEGFR3 and PDGFRA, and can effectively treat diseases that are regulated and controlled by multi-target kinases and are related to abnormal signal transduction pathways of the multi-target kinases, including cancers of breast, respiratory tract, brain, reproductive organ, digestive tract, urinary tract, eye, liver, skin, head and/or neck and distant metastatic cancers thereof, and lymphoma, sarcoma, leukemia and the like. The active ingredients of the pharmaceutical composition of the present invention comprise a multi-target kinase inhibitor, which accounts for 1-50 wt % of the composition.

Abstract: A closed-loop control system for intelligent soot blowing of a utility boiler is provided, including an intelligent soot blowing server, a distributed control system, a physical isolation device, a client and a heating surface soot blower group, where the intelligent soot blowing server communicates with the DCS via the physical isolation device, reads data from the DCS, and sends a soot blowing alarm signal or a soot blowing control signal to the DCS after processing the data; the client and the heating surface soot blower group establish communication links with the DCS separately; a program and a control flow of the closed-loop control system for intelligent soot blowing is developed; a time protection soot blowing flow for a heating surface of an air pre-heater is set in the control flow; a screen of the closed-loop control system for intelligent soot blowing is set up and installed in the DCS.