Abstract: The present invention is a solid effervescent mixture for oral absorption which comes in the following forms: tablets, pills, granules, chewing gum, and candy. The formulation and preparation methods of the solid effervescent mixture are also disclosed. The solid effervescent formulation is administrated orally without water for dissolving and swallowing. In general, the present invention is directed to a solid or other mixture that comprises an orally administrable therapeutic agent or agents, in combination with an effervescent formulation that may be used as an absorption enhancer for the therapeutic agents across the buccal, sublingual, and/or gingival mucosa in order to relieve local and systemic symptoms rapidly.