Abstract: Provided are a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, ether, ester, prodrug and solvate thereof. The compound can be used for preventing and/or treating cancers.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for determining routing. An exemplary method comprises: inputting a plurality of to-be-optimized routing solution candidates to a Siamese neural network comprising a plurality of value prediction networks, each of the value prediction networks being trained to predict a cost associated with a to-be-optimized routing solution candidate; identifying one or more to-be-optimized routing solution candidates from the plurality of to-be-optimized routing solution candidates based on outputs of the Siamese neural network; inputting the one or more identified to-be-optimized routing solution candidates to a routing optimizer to obtain one or more optimized routing solution candidates; and determining an optimized routing solution with a lowest cost from the one or more optimized routing solution candidates.

Abstract: A target detection method and apparatus, in which the method includes: obtaining a target candidate region in a to-be-detected image; determining at least two part candidate regions from the target candidate region by using an image segmentation network, where each part candidate region corresponds to one part of a to-be-detected target; and extracting, from the to-be-detected image, local image features corresponding to the part candidate regions; and learning the local image features of the part candidate regions by using a bidirectional long short-term memory LSTM network, to obtain a part relationship feature used to describe a relationship between the part candidate regions; and detecting the to-be-detected target in the to-be-detected image based on the part relationship feature. As a result, image data processing precision in target detection can be improved, application scenarios of target detection can be diversified, and target detection accuracy can be improved.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for determining routing. An exemplary method comprises: inputting a plurality of to-be-optimized routing solution candidates to a Siamese neural network comprising a plurality of value prediction networks, each of the value prediction networks being trained to predict a cost associated with a to-be-optimized routing solution candidate; identifying one or more to-be-optimized routing solution candidates from the plurality of to-be-optimized routing solution candidates based on outputs of the Siamese neural network; inputting the one or more identified to-be-optimized routing solution candidates to a routing optimizer to obtain one or more optimized routing solution candidates; and determining an optimized routing solution with a lowest cost from the one or more optimized routing solution candidates.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for risk detection. One exemplary method may comprise: obtaining a first subset of a plurality of risk-detection rules, the first subset being associated with a first coverage score; constructing, based on the first subset, a lower-bound data mapping that outputs an approximate coverage score for an input subset; and constructing, based on the first subset, an upper-bound data mapping comprising a set of parameters; and generating a third subset of the plurality of risk-detection rules; and in response to the first coverage score exceeding the third coverage score, selecting rules in the first subset for risk-detection on a new transaction.

Abstract: A virtual reality interaction method comprises: continuously acquiring image information in front of a user; recognizing a preset interactive object by recognizing a preset identifier in the image information, a surface of the preset interactive object having one or more of the preset identifiers; recognizing a hand action of the user according to the image information; and simulating an interactive action of the user on the preset interactive object in a virtual reality environment according to the hand action and a position of the preset interactive object. The virtual reality interaction method provided by the present disclosure can accurately simulate an interactive action of the user on a real object in a virtual reality environment, thereby improving user experience of virtual reality.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for optimizing resource allocation are provided. One of the methods includes: processing a plurality of first objective functions in parallel to determine a plurality of allocation plans, wherein each of the allocation plans corresponds to allocating zero or more of a plurality of resources associated with a platform to a user, and the plurality of first objective functions share one or more dual multipliers; determining a plurality of profits and costs for the platform in parallel based on the plurality of the allocation plans; aggregating the calculated profits and costs using parallel reduction; updating the one or more dual multipliers based on the aggregated costs to determine whether an exit condition is satisfied; if the exit condition is not satisfied, repeating the processing the plurality of the first objective functions based on the updated dual multipliers.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for determining routing using reinforcement learning (RL) are provided. One of the methods includes: initializing a state of an RL model based on a routing solution, wherein the RL model comprises a plurality of improvement actions for applying to the state; applying one or more of the plurality of improvement actions to the state to obtain updated routing solutions until a predetermined condition is satisfied; applying a perturbation action to obtain a perturbed routing solution and feeding the perturbed routing solution back to the RL model for the RL model to perform the applying one or more of the plurality of improvement actions according to the policy; and determining a routing solution with a minimum cost from the updated routing solutions.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for optimizing resource allocation are provided. One of the methods includes: processing a plurality of first objective functions in parallel to determine a plurality of allocation plans, wherein each of the allocation plans corresponds to allocating zero or more of a plurality of resources associated with a platform to a user, and the plurality of first objective functions share one or more dual multipliers; determining a plurality of profits and costs for the platform in parallel based on the plurality of the allocation plans; aggregating the calculated profits and costs using parallel reduction; updating the one or more dual multipliers based on the aggregated costs to determine whether an exit condition is satisfied; if the exit condition is not satisfied, repeating the processing the plurality of the first objective functions based on the updated dual multipliers.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for determining routing using reinforcement learning (RL) are provided. One of the methods includes: initializing a state of an RL model based on a routing solution, wherein the RL model comprises a plurality of improvement actions for applying to the state; applying one or more of the plurality of improvement actions to the state to obtain updated routing solutions until a predetermined condition is satisfied; applying a perturbation action to obtain a perturbed routing solution and feeding the perturbed routing solution back to the RL model for the RL model to perform the applying one or more of the plurality of improvement actions according to the policy; and determining a routing solution with a minimum cost from the updated routing solutions.

Abstract: Highly specific and novel methods for analyzing glycans and proteoglycans are provided. The present invention provides glycan-reactive isobaric Aldehyde-Reactive Tags (iARTs) and the quantification of iARTs-labeled glycans by tandem mass spectrometry. The iARTs have an amine as an active group to react with aldehyde at the reducing end of glycans through reductive amination and demonstrated complete labeling. Due to the isobaric nature of the iARTs, differentially labeled glycans do not differ in mass, and quantitative information is provided by the isotope-encoded reporter ions generated from MS/MS or MS3 spectra. Quantitative information is thus derived from signal of the reporter ions on same precursor. Uses of the information generated by the inventive methods for diagnosis and treatment are also disclosed.

Abstract: A virtual reality interaction method comprises: continuously acquiring image information in front of a user; recognizing a preset interactive object by recognizing a preset identifier in the image information, a surface of the preset interactive object having one or more of the preset identifiers; recognizing a hand action of the user according to the image information; and simulating an interactive action of the user on the preset interactive object in a virtual reality environment according to the hand action and a position of the preset interactive object. The virtual reality interaction method provided by the present disclosure can accurately simulate an interactive action of the user on a real object in a virtual reality environment, thereby improving user experience of virtual reality.

Abstract: A bottom door of a carriage includes a telescoping cylinder and at least two sets of door bodies, each set of the door body is provided with one set of driving mechanisms, each of the driving mechanisms includes a rotating shaft and a driving rod, and the rotating shaft is connected with the respective door body by the driving rod, to allow the door body to be driven to rotate when the rotating shaft rotates; each of the rotating shaft is driven to rotate by the telescoping cylinder, and at least two of the rotating shafts are configured to be driven to rotate successively by the telescoping cylinder.

Abstract: Semiconductor devices including a cathode layer, an anode layer, an active layer disposed between the cathode layer and the anode layer, wherein the active layer includes a perovskite layer, and a passivation layer disposed directly on a surface of the active layer between the cathode layer and the active layer, the passivation layer including a zwitterionic amino acid, such as valine or phenylalanine or other amino acid that passivates both cationic and anionic defects in the surface of the active layer.

Abstract: The disclosure provides quaternary ammonium containing isobaric tag reagents useful in the analysis of biomolecules and methods of making and using the quaternary ammonium containing isobaric tag reagents. The quaternary ammonium containing isobaric tag reagents are particularly useful for glycan analysis, especially quantitative glycan profiling such as glycan quantitation by tandem mass spectrometry.

Abstract: Highly specific and novel methods for analyzing glycans and proteoglycans are provided. The present invention provides glycan-reactive isobaric Aldehyde-Reactive Tags (iARTs) and the quantification of iARTs-labeled glycans by tandem mass spectrometry. The iARTs have an amine as an active group to react with aldehyde at the reducing end of glycans through reductive amination and demonstrated complete labeling. Due to the isobaric nature of the iARTs, differentially labeled glycans do not differ in mass, and quantitative information is provided by the isotope-encoded reporter ions generated from MS/MS or MS3 spectra. Quantitative information is thus derived from signal of the reporter ions on same precursor. Uses of the information generated by the inventive methods for diagnosis and treatment are also disclosed.

Abstract: The present invention discloses a method and an apparatus to automatically remove crosstalk, which can automatically mask G.fast frequencies that will produce crosstalk between an existing transmission line and each port of a DPU/DSLAM equipment without unnecessary manual operation, to automatically remove crosstalk interference between G.fast and the existing transmission line, and is applicable for various generic interfaces. According to the present invention, the installation time is greatly reduced, human errors are also reduced, and the installation can be done correctly by ordinary technicians, which is advantageous to the promotion of G.fast systems.

Abstract: A virtual reality interaction method comprises: continuously acquiring image information in front of a user; recognizing a preset interactive object by recognizing a preset identifier in the image information, a surface of the preset interactive object having one or more of the preset identifiers; recognizing a hand action of the user according to the image information; and simulating an interactive action of the user on the preset interactive object in a virtual reality environment according to the hand action and a position of the preset interactive object. The virtual reality interaction method provided by the present disclosure can accurately simulate an interactive action of the user on a real object in a virtual reality environment, thereby improving user experience of virtual reality.

Abstract: Provided are a method and system for upgrading firmware. The method includes: an upgrading control single board receives a firmware upgrading request from a master control single board, wherein the firmware upgrading request carries firmware upgrading parameter information; the upgrading control single board determines, according to the firmware upgrading parameter information, a sublink to be upgraded corresponding to the firmware upgrading parameter information; and the upgrading control single board acquires, from the master control single board, firmware upgrading data corresponding to the sublink to be upgraded, and upgrades, by adopting the firmware upgrading data, one or more pieces of firmware on the sublink to be upgraded. According to the solution, under a power-on state of a bare single board to be upgraded, remote firmware upgrading can be performed for the single board, so that the risk of influence of firmware upgrading operation on normal running of the system is lowered.

Abstract: Highly specific and novel methods for analyzing glycans and proteoglycans are provided. Uses of the information generated by the inventive methods for diagnosis and treatment are also disclosed.