Patents by Inventor Shuangming Ye

Shuangming Ye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12239613
    Abstract: The present invention provides a preparation method for a carotenoid preparation having high bioavailability and high stability, comprising the following steps: a) dissolving part of a water-soluble colloid and a filling substance in water to form an aqueous phase; b) adding a carotenoid crystal to the aqueous phase and stirring for dispersion so as to form a dispersion liquid; c) loading the dispersion liquid into a first-stage grinding machine for first grinding to form a first-stage grinding liquid; d) adding the remaining water-soluble colloid and filling substance to the first-stage grinding liquid, loading same into a second grinding machine for secondary grinding to obtain a second-stage grinding liquid; and e) drying the moisture in the second-stage grinding liquid to obtain carotenoid dry powder or particles.
    Type: Grant
    Filed: March 10, 2020
    Date of Patent: March 4, 2025
    Assignee: ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY
    Inventors: Xinde Xu, Di Zhou, Tian Xie, Shuangming Ye, Shengnan Wang
  • Publication number: 20220160653
    Abstract: The present invention provides a preparation method for a carotenoid preparation having high bioavailability and high stability, comprising the following steps: a) dissolving part of a water-soluble colloid and a filling substance in water to form an aqueous phase; b) adding a carotenoid crystal to the aqueous phase and stirring for dispersion so as to form a dispersion liquid; c) loading the dispersion liquid into a first-stage grinding machine for first grinding to form a first-stage grinding liquid; d) adding the remaining water-soluble colloid and filling substance to the first-stage grinding liquid, loading same into a second grinding machine for secondary grinding to obtain a second-stage grinding liquid; and e) drying the moisture in the second-stage grinding liquid to obtain carotenoid dry powder or particles.
    Type: Application
    Filed: March 10, 2020
    Publication date: May 26, 2022
    Inventors: Xinde XU, Di ZHOU, Tian XIE, Shuangming YE, Shengnan WANG
  • Patent number: 7485738
    Abstract: This invention has disclosed a method for preparation of food-grade zeaxanthin through chemical isomerizaton reaction from lutein. The technical issues to be solved in this invention are quite low product yield obtained with existing methods, need of purification treatment process, and inadaptability to industrialized production. The technical schemes of this invention are: a. Mix xanthophyll crystal or its fatty acid ester with food-grade glycol or propylene glycol, for full dissolution under 60-90° C. temperature. Add organic alkali into the mixed liquor acquired from step 1, for isomerization reaction to take place under inertial environment. c. Dilute the reaction solution gained from step b with the mixed solution of deionized water and ethanol, and separate the obtained crystal with conventional separating method. d. Vacuum dries the acquired crystal from step c, to get the zeaxanthin crystal.
    Type: Grant
    Filed: September 18, 2007
    Date of Patent: February 3, 2009
    Assignee: Zhejiang Medicine Co., Ltd., XinChang Pharmaceutical Factory
    Inventors: Xinde Xu, Lihua Zhang, Boqiu Chen, Di Zhou, Shuangming Ye, Chiyu Ding, Hongping Lv, Bin Shao
  • Publication number: 20080081932
    Abstract: This invention has disclosed a method for preparation of food-grade zeaxanthin through chemical isomerizaton reaction from lutein. The technical issues to be solved in this invention are quite low product yield obtained with existing methods, need of purification treatment process, and inadaptability to industrialized production. The technical schemes of this invention are: a. Mix xanthophyll crystal or its fatty acid ester with food-grade glycol or propylene glycol, for full dissolution under 60-90° C. temperature. Add organic alkali into the mixed liquor acquired from step 1, for isomerization reaction to take place under inertial environment. c. Dilute the reaction solution gained from step b with the mixed solution of deionized water and ethanol, and separate the obtained crystal with conventional separating method. d. Vacuum dries the acquired crystal from step c, to get the zeaxanthin crystal.
    Type: Application
    Filed: September 18, 2007
    Publication date: April 3, 2008
    Applicants: Zhejiang Medicine Co., Ltd., Xinchang Pharmaceutical Factory
    Inventors: Xinde Xu, Lihua Zhang, Boqiu Chen, Di Zhou, Shuangming Ye, Chiyu Ding, Hongping Lv, Bin Shao
  • Patent number: 7271298
    Abstract: A process for isolation and purification of xanthophylls crystals from plant oleoresin is disclosed. The organic solvents involved in the process is no other than food grade alcohol. The process includes saponifying the plant oleoresin containing xanthophyll diesters, neutralizing the saponified reaction mixture with an acid and washing water-soluble impurities and other fat-soluble oil with warm water and alcohol, respectively. The process can improve purity and yield of products, by which the content and the recovery of xanthophylls are as high as 90% and 80% respectively. And the process is economical and easy to perform in industrial production.
    Type: Grant
    Filed: January 23, 2006
    Date of Patent: September 18, 2007
    Assignee: Zhe Jiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
    Inventors: Xinde Xu, Bin Shao, Di Zhou, Shuangming Ye, Yanfeng Wang, Boqiu Chen
  • Publication number: 20070032683
    Abstract: A process for isolation and purification of xanthophylls crystals from plant oleoresin is disclosed. The organic solvents involved in the process is no other than food grade alcohol. The process includes saponifying the plant oleoresin containing xanthophyll diesters, neutralizing the saponified reaction mixture with an acid and washing water-soluble impurities and other fat-soluble oil with warm water and alcohol, respectively. The process can improve purity and yield of products, by which the content and the recovery of xanthophylls are as high as 90% and 80% respectively. And the process is economical and easy to perform in industrial production.
    Type: Application
    Filed: January 23, 2006
    Publication date: February 8, 2007
    Applicant: Zhe Jiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
    Inventors: Xinde Xu, Bin Shao, Di Zhou, Shuangming Ye, Yanfeng Wang, Boqiu Chen