Abstract: A novel class of inhibitors of protein kinates that are useful in the treatment of cell proliferative diseases and conditions, and especially those characterised by over-expression of CDK4, CDK6 and/or cyclin D, including certain cancers of lung, breast, brain, central nervous system, colorectal cancer and leukaemias.

Abstract: The present disclosure discloses a time service and positioning network system for an underground chain-shaped large space in a coal mine. The system adopts a base station-level network internal time synchronization method which takes an optical fiber time service as a main part and takes a satellite time service as an auxiliary part to construct a time service and positioning network system with an unified time within the ad-hoc network base stations, based on the ad-hoc network base stations linearly arranged in the underground chain-shaped large space in the coal mine. Through the network construction, the network stabilization and the network application, the system unifies the time reference of the base station-level network and improves the positioning accuracy of the network application by utilization of the base station-level network internal time synchronization method.

Abstract: The present disclosure discloses a time service and positioning network system for an underground chain-shaped large space in a coal mine. The system adopts a base station-level network internal time synchronization method which takes an optical fiber time service as a main part and takes a satellite time service as an auxiliary part to construct a time service and positioning network system with an unified time within the ad-hoc network base stations, based on the ad-hoc network base stations linearly arranged in the underground chain-shaped large space in the coal mine. Through the network construction, the network stabilization and the network application, the system unifies the time reference of the base station-level network and improves the positioning accuracy of the network application by utilization of the base station-level network internal time synchronization method.

Abstract: A transboundary-area water-body monitoring and early warning system includes a monitoring device placed in water body to monitor the water body. The monitoring device comprises a housing body. A control mechanism, a communication mechanism, a sensor and a power box are arranged within the housing body. Power ends of the control mechanism, of the sensor, and of the communication mechanism are electrically connected to an output end of the power box. Control terminals of the communication mechanism and of the sensor are electrically connected to a control terminal of the control mechanism. The control mechanism is configured to receive a signal sent by the sensor, and send the signal from the sensor to a background computer through the communication mechanism. The housing body comprises a lower housing and an upper housing. The lower housing is sealably connected to the upper housing.

Abstract: Disclosed are salts of N-Cyclopentyl-5-(2-((5-((4-ethylpiperazin-1-yl) methyl) pyridin-2-yl) amino)-5-fluoropyrim-idin-4-yl)-4-methylthiazol-2-amine and polymorphs thereof, which are inhibitors of protein kinases, in particular cyclin-dependent kinase 4/6 (CDK4/6), and can be used to treat proliferative disorders, such as cancer, and other diseases related to protein kinase/CDK activity.

Abstract: 2-oxo-N-(4-(pyrimidin-4-yloxy/thio)phenyl)-1,2-dihydropyridine-3-carboxamide derivatives are disclosed for use in the prevention and/or treatment of proliferative cell diseases and conditions including cancers. The compounds are considered to be capable of inhibiting cell proliferation and cause cancer cell apoptosis by inhibiting the activity of receptor tyrosine kinases (RTKs) such as TYRO3, AXL, MER and/or MET.

Abstract: Methods and uses of Rilpivirine and analogues thereof in the treatment and/or prevention of proliferative cell diseases and conditions are disclosed. Among the diseases and conditions that may be treated and/or prevented, are cancers characterised by Aurora A dysregulation.

Abstract: The present disclosure discloses a remote sensing-based extraction method for a type of a river channel, including: obtaining multi-source remote sensing data of a target area including a river channel; preprocessing the multi-source remote sensing data, and obtaining corresponding reflectance data; according to the reflectance data, analyzing a water index and a vegetation index of the target area; and according to the water index and the vegetation index, constructing first preset conditions for determining whether there is water in the river channel and second preset conditions for determining whether the river channel is a non-dry river channel to determine the type of the river channel. Types of river channels can be divided into four types: non-dry river channels, seasonal dry river channels, temporary water channels, and dry river channels.

Abstract: A class of thiazole-pyrimidine compounds is disclosed for use in the treatment of proliferative cell diseases and conditions in the CNS including glioblastoma. The compounds are considered to be capable of blocking tumour cell proliferation by inhibiting the activity of CDK4 and/or CDK6 and are capable of crossing the blood brain barrier.

Abstract: A novel class of inhibitors of protein kinases useful in the treatment of proliferative cell diseases and conditions including cancers, and especially those characterised by over-expression of CDK8 and/or one or more aberrant CDK8 activity, including certain cancers of lung, breast, brain, ovary, prostate, colorectal cancer and leukaemias. The inhibitors have the general structure I.

Abstract: Disclosed are a tartrate of 3-(5-fluoro-4-(4-methyl-2-(methylamino)thiazol-5-yl) pyrimidin-2-ylamino)-benzenesulfonamide and a polymorph thereof, which are inhibitors of protein kinases, in particular cyclin-dependent kinase 9 (CDK9), and can be used to treat proliferative disorders, such as cancer, and other diseases related to protein kinase/CDK activity.

Abstract: The present disclosure provides methods and systems for vehicle verification. The method may include receiving vehicle verification information related to a vehicle to be verified from a client, wherein the vehicle verification information includes a plurality of images acquired by the client via an imaging device, and the vehicle verification information responds to at least one vehicle verification instruction. The method may further include determining a verification result of the vehicle based on the vehicle verification information.

Abstract: A novel class of inhibitors of protein kinates that are useful in the treatment of cell proliferative diseases and conditions, and especially those characterised by over-expression of CDK4, CDK6 and/or cyclin D, including certain cancers of lung, breast, brain, central nervous system, colorectal cancer and leukaemias.

Abstract: A novel class of heteroaryl compounds for use in the prevention and/or treatment of proliferative diseases and conditions including cancers. The compounds are considered to be capable of inhibiting cell proliferation by inhibiting the activity of FLT3 and its mutant forms and/or other protein kinases such as CDKs.

Abstract: A novel class of inhibitors of protein kinases useful in the treatment of proliferative cell diseases and conditions including cancers, and especially those characterised by over-expression of CDK8 and/or one or more aberrant CDK8 activity, including certain cancers of lung, breast, brain, ovary, prostate, colorectal cancer and leukaemias. The inhibitors have the general structure I.

Abstract: A transboundary-area water-body monitoring and early warning system includes a monitoring device placed in water body to monitor the water body. The monitoring device comprises a housing body. A control mechanism, a communication mechanism, a sensor and a power box are arranged within the housing body. Power ends of the control mechanism, of the sensor, and of the communication mechanism are electrically connected to an output end of the power box. Control terminals of the communication mechanism and of the sensor are electrically connected to a control terminal of the control mechanism. The control mechanism is configured to receive a signal sent by the sensor, and send the signal from the sensor to a background computer through the communication mechanism. The housing body comprises a lower housing and an upper housing. The lower housing is sealably connected to the upper housing.

Abstract: A novel class of inhibitors of protein kinases that are useful in the treatment of cell proliferative diseases and conditions, and especially those characterised by over-expression of one or more CDK enzyme and/or by one or more aberrant CDK activity, including certain cancers of lung, breast, brain, ovary, prostate, colorectal cancer and leukaemias. The inhibitors have the general structure (I).

Abstract: Disclosed are a tartrate of 3-(5-fluoro-4-(4-methyl-2-(methylamino)thiazol-5-yl) pyrimidin-2-ylamino)-benzenesulfonamide and a polymorph thereof, which are inhibitors of protein kinases, in particular cyclin-dependent kinase 9 (CDK9), and can be used to treat proliferative disorders, such as cancer, and other diseases related to protein kinase/CDK activity.

Abstract: A novel class of inhibitors of protein kinases useful in the treatment of proliferative cell diseases and conditions including cancers, and especially those characterised by over-expression of CDK8 and/or one or more aberrant CDK8 activity, including certain cancers of lung, breast, brain, ovary, prostate, colorectal cancer and leukaemias. The inhibitors have the general structure I.

Abstract: A novel class of inhibitors of protein kinases that are useful in the treatment of cell proliferative diseases and conditions, and especially those characterised by over-expression of CDK4, CDK6 and/or cyclin D, including certain cancers of lung, breast, brain, central nervous system, colorectal cancer and leukaemias.