Patents by Inventor Shuenn-Chen Yang

Shuenn-Chen Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dnazyme for silencing the expression of EGFR
    Patent number: 9856480
    Abstract: The invention provides DNAzymes which are capable to silence the expression of EGFR at allele-specific level. These allele-specific DNAzymes against EGFR T790M mutation will knockdown the expression of EGFR T790M mRNA while keeping EGFR wild-type mRNA intact. Hence, these allele-specific DNAzymes against EGFR T790M mutation may overcome T790M-derived TKI resistance accompanied with lower unwanted side effects on normal cells in lung cancer patients.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: January 2, 2018
    Assignees: National Taiwan University, ACADEMIA SINICA
    Inventors: Pan-Chyr Yang, Wei-Yun Lai, Konan Peck, Cheng-Ju Chang, Chi-Yuan Chen, Shuenn-Chen Yang
  • Antofine and cryptopleurine derivatives as anticancer agents
    Patent number: 9216977
    Abstract: The present invention provides compounds of Formula (I-IV): compositions containing the same, and methods of use thereof such as for the treatment of cancer.
    Type: Grant
    Filed: September 22, 2010
    Date of Patent: December 22, 2015
    Assignees: The University of North Carolina at Chapel Hill, National Taiwan University
    Inventors: Kuo-Hsiung Lee, Xiaoming Yang, Qian Shi, Kenneth F. Bastow, Che-Ming Teng, Tse-Ming Hong, Pan-Chyr Yang, Shuenn-Chen Yang
  • ANTOFINE AND CRYPTOPLEURINE DERIVATIVES AS ANTICANCER AGENTS
    Publication number: 20120283220
    Abstract: The present invention provides compounds of Formula (I-IV): compositions containing the same, and methods of use thereof such as for the treatment of cancer.
    Type: Application
    Filed: September 22, 2010
    Publication date: November 8, 2012
    Inventors: Kuo-Hsiung Lee, Xiaoming Yang, Qian Shi, Kenneth F. Bastow, Che-Ming Teng, Tse-Ming Hong, Pan-Chyr Yang, Shuenn-Chen Yang
  • Collapsin response mediator protein-1
    Patent number: 7354709
    Abstract: This invention is based on the discovery of an association of Collapsin Response Mediator Protein-1 (CRMP-1) with tumor metastasis. The level of CRMP-1 protein or mRNA can be used as an indicator of cellular invasiveness and of a test compound's ability to alter cellular invasiveness. The level of CRMP-1 protein can also be altered, e.g., to reduce invasiveness.
    Type: Grant
    Filed: June 25, 2002
    Date of Patent: April 8, 2008
    Assignees: National Taiwan University, Academia Sinica, National Health Research Institutes
    Inventors: Pan-Chyr Yang, Jin-Yuan Shih, Jeremy J. W. Chen, Konan Peck, Cheng-Wen Wu, Tse-Ming Hong, Shuenn-Chen Yang
  • Collapsin response mediator protein-1
    Publication number: 20030077624
    Abstract: This invention is based on the discovery of an association of Collapsin Response Mediator Protein-1 (CRMP-1) with tumor metastasis. The level of CRMP-1 protein or mRNA can be used as an indicator of cellular invasiveness and of a test compound's ability to alter cellular invasiveness. The level of CRMP-1 protein can also be altered, e.g., to reduce invasiveness.
    Type: Application
    Filed: June 25, 2002
    Publication date: April 24, 2003
    Inventors: Pan-Chyr Yang, Jin-Yuan Shih, Jeremy J. W. Chen, Konan Peck, Cheng-Wen Wu, Tse-Ming Hong, Shuenn-Chen Yang
  • Metastasis-associated genes
    Publication number: 20030054387
    Abstract: Many genes are identified as being metastasis associated. Identifying and profiling of these genes expression can be used to evaluate a sample, to diagnose tumor invasive potential or metastatic development in a sample, or screen for a test compound useful in the prevention or treatment of tumor metastasis.
    Type: Application
    Filed: June 25, 2002
    Publication date: March 20, 2003
    Inventors: Jeremy J.W. Chen, Pan-Chyr Yang, Konan Peck, Tse-Ming Hong, Shuenn-Chen Yang, Cheng-Wen Wu