Abstract: A sensor includes: a substrate, a chip, and a protective layer. The chip is arranged on a surface of the substrate, the protective layer includes a silica gel protective layer, a silica gel active layer, and a strength-increasing protective layer. the silica gel protective layer is coated on the chip and adheres to the substrate; the silica gel active layer is coated on an outer surface of the silica gel protective layer, and adhesion of the silica gel active layer is greater than adhesion of the silica gel protective layer; the strength-increasing protective layer is coated on and adheres to an outer surface of the silica gel active layer, and the strength-increasing protective layer adheres to the substrate; and a strength of the strength-increasing protective layer is greater than a strength of the silica gel protective layer.

Abstract: The present invention relates to the field of oncology, particularly the early diagnostic of lung cancer, the monitoring of lung cancer patients and the prediction of the clinical outcome of patients. The invention relates to a method for diagnosing lung cancer or diagnosing relapse of lung cancer in patients by determination of the level of methylation of gene(s) and the kit to implement said method.

Abstract: A galvanometer positioning tool and a laser printer. The galvanometer positioning tool includes: a base provided with a bearing surface and provided with a first concave spherical surface; a bracket placed on the bearing surface, a positioning assembly being provided on a side surface of the bracket facing the bearing surface, a galvanometer being mounted on the bracket; and a reflection center of the galvanometer located on the spherical center of the sphere where the first concave spherical surface is located. The rotation assembly includes a first rotation rod fixedly connected to the second rotation rod and rotatably connected to the base. The second rotation rod is slidably connected to the bracket, and when the first rotation rod rotates relative to the base, the first rotation rod is capable of driving the bracket to rotate with the y-axis of the galvanometer as a rotation axis.

Abstract: A sensor includes: a substrate, a chip, and a protective layer. The chip is arranged on a surface of the substrate, the protective layer includes a silica gel protective layer, a silica gel active layer, and a strength-increasing protective layer. the silica gel protective layer is coated on the chip and adheres to the substrate; the silica gel active layer is coated on an outer surface of the silica gel protective layer, and adhesion of the silica gel active layer is greater than adhesion of the silica gel protective layer; the strength-increasing protective layer is coated on and adheres to an outer surface of the silica gel active layer, and the strength-increasing protective layer adheres to the substrate; and a strength of the strength-increasing protective layer is greater than a strength of the silica gel protective layer.

Abstract: The invention relates to a method for diagnosing or identifying gastric cancer in a subject. The inventors indeed identified three DNA methylation biomarkers that, alone, or preferably in combination, can help diagnosing or following-up gastric cancer patients very specifically, discriminating with other type of cancers. Further, it can be used for determining, and/or adapting a suitable therapeutic regimen for a subject diagnosed for gastric cancer. The present invention also relates to kits comprising primers or probes to detect, diagnose, or identify hypermethylated genes.

Abstract: Specific, accurate, and cost effective primers for performing digital PCR, compositions and kits containing the primer and methods for using and making the same are useful for detecting nucleic acid mutations. A primer useful as a first forward primer in performing digital PCR to detect a target nucleic acid in a sample, includes: a detection portion located upstream to a target sequence binding portion, and including a second forward primer binding portion having a sequence substantially complementary to a second forward primer, and a probe binding portion downstream to the second forward primer binding portion having a sequence substantially complementary to a probe; the target sequence binding portion includes a mismatch portion having a sequence not complementary to the target nucleic acid, and an amplification determinant portion downstream to the mismatch portion having a sequence complementary to a gene allele or a variant thereof encoded by the target nucleic acid.

Abstract: The invention relates to a method for diagnosing or identifying pancreas cancer in a subject. The inventors indeed identified two DNA methylation biomarkers that, alone, preferably in combination, can help diagnosing or following-up pancreatic cancer patients very specifically, discriminating with other type of cancers. Further, it can be used for determining, adapting a suitable therapeutic regimen for a subject diagnosed for pancreas cancer. The present invention also relates to kit comprising primers or probes to detect, diagnose, identify hypermethylated genes.

Abstract: Specific, accurate, and cost effective primers for performing digital PCR, compositions and kits containing the primer and methods for using and making the same are useful for detecting nucleic acid mutations. A primer useful as a first forward primer in performing digital PCR to detect a target nucleic acid in a sample, includes: a detection portion located upstream to a target sequence binding portion, and including a second forward primer binding portion having a sequence substantially complementary to a second forward primer, and a probe binding portion downstream to the second forward primer binding portion having a sequence substantially complementary to a probe; the target sequence binding portion includes a mismatch portion having a sequence not complementary to the target nucleic acid, and an amplification determinant portion downstream to the mismatch portion having a sequence complementary to a gene allele or a variant thereof encoded by the target nucleic acid.

Abstract: The invention provides a fluidized bed polymerization reactor, including: a column, in which a liquid distributor and a gas distributor above the liquid distributor are arranged, so that the reaction zone being divided into a first zone and a second zone through the gas distributor; and a circulating unit for circulating the gas material originated from the top zone of the column into the bottom zone thereof in a form of gas-liquid mixture. The gas-liquid mixture is undergone a gas-liquid separation in the bottom zone, the gas phase portion obtained being fed to the gas distributor and then into the second zone while the liquid phase portion obtained being entered into the first zone through the liquid distributor, so that the temperature in the first zone is lower than that in the second zone. Therefore, polymer with a molecular weight distributed in a relatively wide range can be obtained. The invention further provides a method for preparing polymer.

Abstract: The invention provides a fluidized bed polymerization reactor, including: a column, in which a liquid distributor and a gas distributor above the liquid distributor are arranged, so that the reaction zone being divided into a first zone and a second zone through the gas distributor; and a circulating unit for circulating the gas material originated from the top zone of the column into the bottom zone thereof in a form of gas-liquid mixture. The gas-liquid mixture is undergone a gas-liquid separation in the bottom zone, the gas phase portion obtained being fed to the gas distributor and then into the second zone while the liquid phase portion obtained being entered into the first zone through the liquid distributor, so that the temperature in the first zone is lower than that in the second zone. Therefore, polymer with a molecular weight distributed in a relatively wide range can be obtained. The invention further provides a method for preparing polymer.

Abstract: A composite catalyst useful in the production of polyethylene, which comprises at least a first catalyst and a second catalyst separated by a polymer layer, with the first catalyst and the second catalyst being identical or different, is described. A composite catalyst useful in the production of polyethylene with a broad molecular weight distribution in a single polymerization reactor, which comprises at least a first catalyst and a second catalyst separated by a polymer layer, with the first catalyst and the second catalyst being different, is also described. A process for preparing said catalysts and a process for the production of a polyethylene by using said catalysts are also described.

Abstract: A composite catalyst useful in the production of polyethylene, which comprises at least a first catalyst and a second catalyst separated by a polymer layer, with the first catalyst and the second catalyst being identical or different, is described. A composite catalyst useful in the production of polyethylene with a broad molecular weight distribution in a single polymerization reactor, which comprises at least a first catalyst and a second catalyst separated by a polymer layer, with the first catalyst and the second catalyst being different, is also described. A process for preparing said catalysts and a process for the production of a polyethylene by using said catalysts are also described.