Abstract: A noise cancelling headphone includes a headphone body, a audio player and a central processing unit. The headphone body includes a headband, a first speaker unit and a second speaker unit. The elongated headband is bent and shaped to fittedly and adjustably wear on a user's head, wherein the headband has a first and a second end portion. The first speaker unit and the second speaker unit are attached on the first and the second end portion of the headband respectively. The audio player is provided on the headphone body, and is arranged to read a predetermined kind of audio signals. The central processing unit is received in the headphone body, and is arranged to process the audio signals outputted from the audio player and drive the first speaker unit and the second speaker unit to generate corresponding audible sound.