Abstract: The present inventors discovered that oligonucleotides which suppress midkine expression and antibodies which suppress midkine activity can be used to prevent post-surgical intraperitoneal adhesions.

Abstract: The present inventors discovered that oligonucleotides which suppress midkine expression and antibodies which suppress midkine activity can be used to prevent post-surgical intraperitoneal adhesions.

Abstract: The present inventors discovered that oligonucleotides which suppress midkine expression and antibodies which suppress midkine activity can be used to prevent post-surgical intraperitoneal adhesions.

Abstract: It is intended to provide a pluripotent cell having the following properties: (1) being contained in a mixed-cell type population obtained by enzymatic treatment of the tissue collected from an animal; (2) being contained in a sedimented cell population obtained by centrifugating the mixed-cell type population of the property (1); (3) selectively proliferating by culturing in a medium containing 2% (v/v) or lower serum and 1 to 100 ng/ml of fibroblast growth factor-2; and (4) being differentiated into cells having the characteristics of adipocytes, osteoblasts, chondrocytes, tendon cells, myocardial cells, myoblasts, neurocytes or vascular endothelial cells by adjusting the culture condition; cells having differentiated from the above cell; and a method of conveniently obtaining the pluripotent cell in a large amount.

Abstract: The present inventors discovered that oligonucleotides which suppress midkine expression and antibodies which suppress midkine activity can be used to prevent post-surgical intraperitoneal adhesions.

Abstract: The following are provided: a method for manufacturing artificial cartilages characterized in that undifferentiated mesenchymal cells are cultured in a cartilage differentiation inducing medium, and the cells are irradiated with ultrasound, as a method in which chondrocytes can be obtained in a short time in an amount sufficient for performing the treatment of cartilage disorder with surgical operation when a conservative therapy such as limitation of movement exhibits no effect, among various treatments of cartilage disorder; an artificial cartilage that has been produced by the method; and an apparatus for manufacturing artificial cartilages comprising a culture vessel containing cultured undifferentiated mesenchymal cells, an ultrasound transducer for applying ultrasound to the vessel, a control means for controlling the ultrasound, and a holding water-tank for installing the ultrasound transducer and the culture vessel in the holding water-tank in such a state that they are in contact with each other.