Abstract: Compounds or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds disclosed herein or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.

Abstract: A data analysis apparatus (100) according to this invention includes a controller (10) configured to accept an operation of selection of an analysis data item(s) (500, 510, 520, 530), to accept an operation of selection of a script(s) to be used to analyze data based on the analysis data item(s) (500, 510, 520, 530), to accept an operation of adjustment of a parameter(s) to be used to execute the script(s), and to analyze the data by executing the script(s) based on the adjusted parameter(s).

Abstract: The cell image analysis method includes: an image acquisition step of acquiring a plurality of images of a cell captured at a plurality of imaging distances that are different from each other in the bright field; an index information acquisition step of acquiring index information that is information regarding an index for evaluating a difference between the plurality of images acquired in the image acquisition step; an imaging distance determination step of determining such an imaging distance that a rate of a change in the index information with respect to a change in the imaging distance is equal to or less than a predetermined threshold value; a region extraction step of extracting a cell region included in an image captured at the imaging distance determined in the imaging distance determination step; and a region correction step of performing correction on the cell region extracted in the region extraction step.

Abstract: Provided is a prediction apparatus for predicting a health-oriented behavior tendency of a prediction object, the prediction apparatus including: a health-oriented behavior estimation model storage unit that stores a health-oriented behavior estimation model for estimating a health-oriented behavior based on a relationship between a health-oriented behavior and human characteristics; a human characteristic scale calculation unit that calculates a plurality of human characteristic scales based on human characteristic data indicating human characteristics of a prediction object; and a health-oriented behavior prediction unit that predicts a health-oriented behavior tendency based on the plurality of calculated human characteristic scales by using the health-oriented behavior estimation model.

Abstract: A suction pad includes a body and a sponge member. The sponge member made of a material having a semi-open and semi-closed cell structure includes a plurality of cavities opening toward a workpiece, a tubular stopper attached to the body is disposed in each of the cavities of the sponge member, and a suction passage formed in each stopper communicates with a negative pressure chamber formed in the body. The height of the stopper is set to a dimension that prevents the sponge member from being compressed to a maximum compression amount and allows the sponge member to be compressed until the sponge member exhibits airtightness.

Abstract: A suction pad includes a body and a sponge member. The body includes a negative pressure chamber, and a plurality of communication passages communicating with the negative pressure chamber. The sponge member includes a plurality of cavities opening toward a workpiece. The cavities communicate with the negative pressure chamber through the communication passages, and flow passage adjustment valves for adjusting a flow passage area are arranged in the communication passages, respectively. The suction pad further includes a pressure detection port for detecting pressure in at least one cavity among the plurality of cavities.

Abstract: An optical member having a porous layer having both low scattering and film strength is provided. The optical member is an optical member, having a porous layer in which a plurality of silicon oxide particles are bound with an inorganic binder on a base material, and the porous layer contains a fluorine-containing organic acid having 5 or more and 11 or less fluorine atoms in one molecule.

Abstract: A balloon catheter includes a catheter shaft, a balloon, and a protruding portion. The balloon is connected to the catheter shaft. The balloon includes an inflatable portion and a distal end connecting portion. The protruding portion protrudes radially outward with respect to a center axis of the catheter shaft. The protruding portion has at least one of a first protruding portion provided on the distal end connecting portion of the balloon, or a second protruding portion provided on a distal end extending portion. The distal end connecting portion includes at least a region where a protrusion amount is smaller than a protrusion amount of the protruding portion.

Abstract: A balloon for a catheter includes an inflatable portion, a distal end connecting portion, and a proximal end connecting portion. The balloon for the catheter also includes an inner side thick film portion and a thin film portion having differing thicknesses from each other. The thickness of the inner side thick film portion is greater than the thickness of the thin film portion. An inner surface at the inner side thick film portion protrudes further toward an inner side than an inner surface at the thin film portion. An outer surface at the inner side thick film portion does not protrude further to an outer side in the radial direction than an outer surface at the thin film portion.

Abstract: Provided is an antiviral agent that is suitable not only for application in articles but also for application in living organisms, and that is safer for living organisms. The antiviral agent contains mannosylerythritol lipids (MELs) as an active ingredient, preferably in an amount of 0.000001 to 100 wt %, and is applicable to living organisms and/or articles.

Abstract: A transfer apparatus transfers a transfer substance or a surface shape of a transfer web in a transfer section from the transfer web that is carried along a web route to a transfer target object that is carried along a carrying surface. The transfer apparatus includes a gap adjustment mechanism that adjusts the size of a gap between the carrying surface and the web route in the transfer section, and a controller that controls the gap adjustment mechanism to adjust the size of the gap to be a size corresponding to the thickness of the transfer target object.

Abstract: A program is configured to cause a computer to execute operations, the operations comprising displaying, on a display, an image of an equipment layout in a virtual space corresponding to an interior space of a vehicle, upon accepting a candidate selection operation to select equipment to be used for providing a service in the interior space of the vehicle as candidate equipment and a location in the interior space of the vehicle as a candidate location, determining, with reference to vehicle data defining a specification of the vehicle, whether to allow installation of the candidate equipment at the candidate location, and upon determining to allow installation of the candidate equipment at the candidate location, updating the equipment layout by arranging a model corresponding to the candidate equipment at a location corresponding to the candidate location in the virtual space.

Abstract: An estimation device (200) generates quality prediction data (540) indicating a quality of a drug substance of a biopharmaceutical manufactured by culturing cells, by inputting, into a prediction model (420), measurement data (510) including a measurement result obtained by measuring a substance in a culturing vessel at least one timing after a predetermined time period has passed since the cells have been seeded in a medium. The prediction model (420) is generated by executing a learning process using training data (530) that includes measurement data including a measurement result obtained by measuring a substance in a culturing vessel at a plurality of timings after seeding of the cells in the medium, and quality data obtained by analyzing a drug substance of the biopharmaceutical manufactured from the cells.

Abstract: A capillary array includes N analysis capillaries filled with a separation medium having a refractive index of n3 and used for electrophoretic analysis and N±1 lens capillaries filled with a medium having a refractive index of n4 and not used for the electrophoretic analysis, in which the N analysis capillaries and the N±1 lens capillaries are alternately arranged on the same array plane. When an outer diameter is defined as 2R, an inner diameter is defined as 2r, a refractive index of a medium of an outside is n1, and a refractive index of a material is defined as n2 for each of the N analysis capillaries and the N±1 lens capillaries, and when a refractive index n3 takes any value within the range of 1.33?n3?1.42, R, r, n1, n2, n3, and n4 satisfy a predetermined relationship, whereby the N analysis capillaries are efficiently simultaneously irradiated with the laser beam incident from a side of the array plane.

Abstract: An information processing device includes a controller configured to acquire a detected value of a sensor that detects presence or absence of a person within a predetermined range outside one or more openings that is formed in a wall surface of a first building, each of the one or more openings using light control glass, the wall surface facing outside, and control transmittance of the light control glass based on the detected value of the sensor. A building includes one or more opening that is formed in at least a wall surface that faces outside, the opening using light control glass; a sensor that detects presence or absence of a person within a predetermined range outside the one or more openings; and a control device that controls transmittance of the light control glass based on a detected value of the sensor.

Abstract: When arraying laser-irradiation portions of a plurality of capillaries on the same array plane, simultaneous irradiation of the capillaries with a laser beam incident from the side is enabled by filling the capillaries with a separation medium having a low refractive index of n3<1.36 and by setting n1=1.00, n2=1.46, R/r<5.9, and ?Z?9 ?m, wherein a distance in a direction perpendicular to the array plane between two capillaries, which are farthest from each other in the perpendicular direction among the capillaries in the laser-irradiation portions, is denoted by 2×?Z, wherein an outer radius, an inner radius, a refractive index of an external medium, a refractive index of a material, and a refractive index of an internal medium of each of the capillaries in the laser-irradiation portions are denoted by R, r, n1, n2, and n3, respectively.

Abstract: When laser-irradiation portions of N capillaries with capillary numbers n=1, 2, . . . , and N are arranged on a same plane, a laser-irradiation intensity of each capillary is denoted by L(n), and an output intensity of each capillary by a computer when a light emitting substance having an equal concentration exists inside each capillary is denoted by H(n), an absolute value of an average value of a second derivative of H(n) becomes smaller than an absolute value of an average value of a second derivative of L(n) for any refractive index n3 of a separation medium in a range of 1.33?n3?1.41 by digital correction by the computer, which changes according to the refractive index n3 (see FIG. 11).

Abstract: An article includes a film on a surface thereof, the film containing a resin, an organic azo-based particle, and a Ti- and O-containing particle so that the film is not separated or cracked and has a good design and good heat-shielding properties.

Abstract: A lubricating oil composition with a resin (A) and a base oil (B), the resin (A) is in a range of 0.01 to 50 parts by mass per 100 parts of (A) and (B), the resin (A) satisfies the following requirements: (A-1) the resin (A) is a polymer including a constituent unit from 4-methyl-1-pentene in a range of 60 to 99 mol % and a constituent unit from an ?-olefin having 2 to 20 carbon atoms (excluding 4-methyl-1-pentene) in a range of 1 to 40 mol % (provided that 4-methyl-1-pentene and the ?-olefin is 100 mol %); (A-2) intrinsic viscosity [?] measured in decalin at 135° C. is in a range of 0.01 to 5.0 dl/g; (A-3) a melting point (Tm) is in a range of 110 to 150° C. as determined by DSC; and the base oil (B) has (B-1) kinematic viscosity at 100° C. is in a range of 1 to 50 mm2/s.

Abstract: An optical waveguide element of the present disclosure includes: a waveguide for propagating light; a clad including an upper clad whose lower surface is in contact with one surface of the waveguide and whose upper surface exposed to the outside is formed with a rough surface, and a lower clad whose upper surface is in contact with the other surface of the waveguide and whose lower surface is formed with a reflective surface; an incident end surface provided at one end of the waveguide and the clad; and an emission end surface provided at the other end of the waveguide and the clad, whereby incident light is optically coupled to the waveguide with high efficiency.