Patents by Inventor Shui-Pang Tam

Shui-Pang Tam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for treating atherosclerosis
    Patent number: 8703698
    Abstract: Peptides and mimetics of selected domains of mammalian serum amyloid A isoform 2.1 (SAA2.1) and compounds and compositions thereof are provided that enhance the effect on macrophage cholesterol ester hydrolase activity and/or inhibit acyl CoA:cholesterol acyl transferase activity. Methods of using these compositions in the treatment and/or prevention of atherosclerosis as well as coronary heart disease and cardiovascular disease are also provided.
    Type: Grant
    Filed: February 8, 2010
    Date of Patent: April 22, 2014
    Assignee: The University of Chicago
    Inventors: Robert Kisilevsky, Shui-Pang Tam, John B. Ancsin, Zongchao Jia
  • Compositions and Methods for Treating Atherosclerosis
    Publication number: 20110268768
    Abstract: Peptides and mimetics of selected domains of mammalian serum amyloid A isoform 2.1 (SAA2.1) and compounds and compositions thereof are provided that enhance the effect on macrophage cholesterol ester hydrolase activity and/or inhibit acyl CoA:cholesterol acyl transferase activity. Methods of using these compositions in the treatment and/or prevention of atherosclerosis as well as coronary heart disease and cardiovascular disease are also provided.
    Type: Application
    Filed: November 19, 2010
    Publication date: November 3, 2011
    Applicant: Queen's University at Kingston
    Inventors: Robert Kisilevsky, Shui-Pang Tam, John B. Ancsin, Zongchao Jia
  • Compositions and Methods for Treating Atherosclerosis
    Publication number: 20100279926
    Abstract: Peptides and mimetics of selected domains of mammalian serum amyloid A isoform 2.1 (SAA2.1) and compounds and compositions thereof are provided that enhance the effect on macrophage cholesterol ester hydrolase activity and/or inhibit acyl CoA:cholesterol acyl transferase activity. Methods of using these compositions in the treatment and/or prevention of atherosclerosis as well as coronary heart disease and cardiovascular disease are also provided.
    Type: Application
    Filed: February 8, 2010
    Publication date: November 4, 2010
    Inventors: Robert Kisilevsky, Shui-Pang Tam, John B. Ancsin, Zongchao Jia
  • Compositions and methods for treating atherosclerosis
    Patent number: 7700544
    Abstract: Peptides and mimetics of selected domains of mammalian serum amyloid A isoform 2.1 (SAA2.1) and compounds and compositions thereof are provided that enhance the effect on macrophage cholesterol ester hydrolase activity and/or inhibit acyl CoA:cholesterol acyl transferase activity. Methods of using these compositions in the treatment and/or prevention of atherosclerosis as well as coronary heart disease and cardiovascular disease are also provided.
    Type: Grant
    Filed: November 7, 2005
    Date of Patent: April 20, 2010
    Assignee: Queens's University at Kingston
    Inventors: Robert Kisilevsky, Shui-Pang Tam, John B. Ancsin, Zongchao Jia
  • Labeled Macrophages and Methods of Use Thereof
    Publication number: 20090016956
    Abstract: Methods of making and using labeled macrophages are described.
    Type: Application
    Filed: April 28, 2008
    Publication date: January 15, 2009
    Inventors: Robert Bender, Allan M. Green, Perry Kim, Robert Kisilevsky, Douglas S. McNair, Shui-pang Tam
  • Compositions and Methods for Treating Atherosclerosis
    Publication number: 20080221028
    Abstract: Peptides and mimetics of selected domains of mammalian serum amyloid A isoform 2.1 (SAA2.1) and compounds and compositions thereof are provided that enhance the effect on macrophage cholesterol ester hydrolase activity and/or inhibit acyl CoA:cholesterol acyl transferase activity. Methods of using these compositions in the treatment and/or prevention of atherosclerosis as well as coronary heart disease and cardiovascular disease are also provided.
    Type: Application
    Filed: October 15, 2007
    Publication date: September 11, 2008
    Inventors: Robert Kisilevsky, Shui-Pang Tam, John B. Ancsin, Zongchao Jia
  • Compositions and methods for treating atherosclerosis
    Patent number: 7291590
    Abstract: Peptides and mimetics of selected domains of mammalian serum amyloid A isoform 2.1 (SAA2.1) and compounds and compositions thereof are provided that enhance the effect on macrophage cholesterol ester hydrolase activity and/or inhibit acyl CoA:cholesterol acyl transferase activity. Methods of using these compositions in the treatment and/or prevention of atherosclerosis as well as coronary heart disease and cardiovascular disease are also provided.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: November 6, 2007
    Assignee: Queen's University at Kingston
    Inventors: Robert Kisilevsky, Shui-Pang Tam, John B. Ancsin, Zongchao Jia
  • Compositions and methods for treating atherosclerosis
    Publication number: 20060111299
    Abstract: Peptides and mimetics of selected domains of mammalian serum amyloid A isoform 2.1 (SAA2.1) and compounds and compositions thereof are provided that enhance the effect on macrophage cholesterol ester hydrolase activity and/or inhibit acyl CoA:cholesterol acyl transferase activity. Methods of using these compositions in the treatment and/or prevention of atherosclerosis as well as coronary heart disease and cardiovascular disease are also provided.
    Type: Application
    Filed: November 7, 2005
    Publication date: May 25, 2006
    Inventors: Robert Kisilevsky, Shui-Pang Tam, John Ancsin, Zongchao Jia
  • Compositions and methods for treating atherosclerosis
    Publication number: 20040265982
    Abstract: Peptides and mimetics of selected domains of mammalian serum amyloid A isoform 2.1 (SAA2.1) and compounds and compositions thereof are provided that enhance the effect on macrophage cholesterol ester hydrolase activity and/or inhibit acyl CoA:cholesterol acyl transferase activity. Methods of using these compositions in the treatment and/or prevention of atherosclerosis as well as coronary heart disease and cardiovascular disease are also provided.
    Type: Application
    Filed: June 10, 2004
    Publication date: December 30, 2004
    Inventors: Robert Kisilevsky, Shui-Pang Tam, John B. Ancsin, Zongchao Jia
  • Antioxidant responsive element
    Patent number: 6120994
    Abstract: The present invention relates, in general, to antioxidant responsive elements (AREs). In particular, the present invention relates to a DNA construct comprising an ARE having the DNA sequence 5'-RGR AC NNN GCT-3' (SEQ ID NO: 1) operably linked to a heterologous protein coding sequence; cells and non-human organisms comprising the DNA construct; a method of screening for a compound that increases transcription of an MRNA regulated by an antioxidant responsive element; and a purified compound that binds to an antioxidant responsive element.
    Type: Grant
    Filed: May 23, 1997
    Date of Patent: September 19, 2000
    Assignee: Queen's University at Kingston
    Inventor: Shui-Pang Tam
  • DNA constructs and methods for screening for increased expression of human apo AI gene
    Patent number: 5994061
    Abstract: Methods for screening for a drug that increases expression of the human apolioprotein (apo) AI gene and related DNA constructs. A first method has the steps of: (a) introducing into mammalian cells a DNA construct including, functionally joined together in the 5'.fwdarw.
    Type: Grant
    Filed: September 29, 1995
    Date of Patent: November 30, 1999
    Assignee: Queen's University at Kingston
    Inventors: Shui-Pang Tam, Xia Zhang