Patents by Inventor SHUI QIU

SHUI QIU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ?-transaminase mutant based on ancestral sequence reconstruction
    Patent number: 12698484
    Abstract: The amino acid sequence of a w-transaminase mutant derived from mutation of ?-transaminase from Aspergillus terreus, is as shown in SEQ ID NO. 4 or SEQ ID NO. 6. Compared with the wild-type enzyme, the half-lives of the ?-transaminase mutants are all above 24 h, while the half-life of the wild-type is only 6.90 min. The half-inactivation temperature of the mutants are 49.00° C. and 49.03° C., respectively, which are about 11° C. higher than that of the wild-type (37.89° C.), such that the thermal stability is significantly improved.
    Type: Grant
    Filed: December 5, 2022
    Date of Patent: August 4, 2026
    Assignee: ZHEJIANG UNIVERSITY OF SCIENCE & TECHNOLOGY
    Inventors: Jun Huang, Tingting Cai, Shui Qiu, Lehe Mei, Jiaren Cao, Changjiang Lyu, Fangfang Fan, Sheng Hu, Ye Li, Weirui Zhao, Feng Wang, Yuanyuan Li
  • AN OMEGA-TRANSAMINASE MUTANT BASED ON ANCESTRAL SEQUENCE RECONSTRUCTION
    Publication number: 20250304928
    Abstract: The present invention discloses an ?-transaminase mutant based on ancestral sequence reconstruction and relates to the technical field of molecular biology. The amino acid sequence of said ?-transaminase mutant derived from mutation of ?-transaminase from Aspergillus terreus, is as shown in SEQ ID NO. 4 or SEQ ID NO. 6. Compared with the wild-type enzyme, the half-lives of the ?-transaminase mutants are all above 24 h, while the half-life of the wild-type is only 6.90 min. The half-inactivation temperature of the mutants are 49.00° C. and 49.03° C., respectively, which are about 11° C. higher than that of the wild-type (37.89° C.), such that the thermal stability is significantly improved.
    Type: Application
    Filed: December 5, 2022
    Publication date: October 2, 2025
    Inventors: JUN HUANG, TINGTING CAI, SHUI QIU, LEHE MEI, JIAREN CAO, CHANGJIANG LYU, FANGFANG FAN, SHENG HU, YE LI, WEIRUI ZHAO, FENG WANG, YUANYUAN LI