Abstract: A UV light sterilization device includes a main body with an accommodation space defined therein for a predetermined item to be placed in a horizontal direction, a power supply module mounted in one side plate of the main body and providing an electrical connection port, and a UV lamp set with a drive control circuit assembled on the bottom side of the top cover of the main body and electrically connected to the electrical connection port, the drive control circuit having a plurality of evenly distributed UV LED chips for downwardly irradiating the surface of the predetermined item that is placed in the main body.