Patents by Inventor Shuichi Hirono

Shuichi Hirono has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7772285
    Abstract: A benzophenone derivative represented by the following formula: wherein R1 represents, for example, an optionally substituted heterocyclic group, or a substituted phenyl group; Z represents, for example, an alkylene group; R2 represents, for example, a carboxyl group optionally protected with alkyl; R3 represents, for example, an optionally protected hydroxyl group; R4 represents, for example, an optionally substituted cycloalkyloxy group; and R5 represents, for example, a hydrogen atom, or a salt thereof has anti-arthritic activity, inhibits bone destruction caused by arthritis, and provides high safety and excellent pharmacokinetics and thus is useful as therapeutic agent for arthritis. These compounds have inhibitory effect on AP-1 activity and are useful as preventive or therapeutic agent for diseases in which excessive expression of AP-1 is involved.
    Type: Grant
    Filed: November 13, 2002
    Date of Patent: August 10, 2010
    Assignee: Toyama Chemical Co., Ltd.
    Inventors: Hisaaki Chaki, Hironori Kotsubo, Tadashi Tanaka, Yukihiko Aikawa, Shuichi Hirono, Shunichi Shiozawa
  • Publication number: 20090118169
    Abstract: A compound comprising the atom corresponding to N3 and the two or more atoms selected from N1, N2, N4 and N5, said atoms constitute the pharmacophore represented by the following formula: wherein N1 represents an atom to which a donative hydrogen atom in a hydrogen-bond donating group is bonded or a hydrogen-bond accepting atom in a hydrogen-bond accepting group; N3 represents a hydrogen-bond accepting atom in a hydrogen-bond accepting group; and N2, N4 and N5 independently represents an arbitrary carbon atom constituting a hydrophobic group and defined by the interatomic distances between N1, N2, N3, N4 and N5; and, in the optimized three-dimensional structure thereof, the distances between the atom corresponding to N3 and the two or more atoms selected from N1, N2, N4 and N5, in the optimized steric structure thereof, are the interatomic distances in a pharmacophore; or a salt thereof; inhibits the activity of transcription factor AP-1 and is useful as an agent for preventing and treating the diseases i
    Type: Application
    Filed: November 16, 2007
    Publication date: May 7, 2009
    Applicant: TOYAMA CHEMICAL CO., LTD.
    Inventors: Hisaaki Chaki, Tadakazu Takakura, Keiichi Tsuchida, Hironori Kotsubo, Yukihiko Aikawa, Shuichi Hirono, Shunichi Shiozawa
  • Patent number: 7314888
    Abstract: A compound or a salt thereof having the atom corresponding to N3 and the two or more atoms selected from N1, N2, N4 and N5, said atoms constitute the pharmacophore represented by the following formula: and inhibits the activity of transcription factor AP-1 and is useful as an agent for preventing and treating the diseases into which over expression of AP-1 participates and as an AP-1 inhibitor.
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: January 1, 2008
    Assignee: Toyama Chemical Co., Ltd.
    Inventors: Hisaaki Chaki, Tadakazu Takakura, Keiichi Tsuchida, Hironori Kotsubo, Yukihiko Aikawa, Shuichi Hirono, Shunichi Shiozawa
  • Patent number: 6937940
    Abstract: With compounds for drugs, agricultural chemicals, etc., the invention provides a novel method for superposing molecular structures of those compounds.
    Type: Grant
    Filed: June 13, 2001
    Date of Patent: August 30, 2005
    Assignee: Kyorin Pharmaceutical Co., Ltd.
    Inventors: Shuichi Hirono, Kazuhiko Iwase
  • Publication number: 20050113400
    Abstract: A benzophenone derivative represented by the following formula: wherein R1 represents, for example, an optionally substituted heterocyclic group, or a substituted phenyl group; Z represents, for example, an alkylene group; R2 represents, for example, a carboxyl group optionally protected with alkyl; R3 represents, for example, an optionally protected hydroxyl group; R4 represents, for example, an optionally substituted cycloalkyloxy group; and R5 represents, for example, a hydrogen atom, or a salt thereof has anti-arthritic activity, inhibits bone destruction caused by arthritis, and provides high safety and excellent pharmacokinetics and thus is useful as therapeutic agent for arthritis. These compounds have inhibitory effect on AP-1 activity and are useful as preventive or therapeutic agent for diseases in which excessive expression of AP-1 is involved.
    Type: Application
    Filed: November 13, 2002
    Publication date: May 26, 2005
    Inventors: Hisaaki Chaki, Hironori Kotsubo, Tadashi Tanaka, Yukihiko Aikawa, Shuichi Hirono, Shunichi Shiozawa
  • Publication number: 20040038429
    Abstract: The invention provides a technique for finding out compounds with potential to become leads in the compounds of medicinal drugs, agricultural chemicals, etc.
    Type: Application
    Filed: May 12, 2003
    Publication date: February 26, 2004
    Inventors: Shuichi Hirono, Kazuhiko Iwase
  • Publication number: 20030149533
    Abstract: With compounds for drugs, agricultural chemicals, etc., the invention provides a novel method for superposing molecular structures of those compounds.
    Type: Application
    Filed: December 13, 2002
    Publication date: August 7, 2003
    Inventors: Shuichi Hirono, Kazuhiko Iwase
  • Patent number: 6384065
    Abstract: The spiro compounds of the present invention represented by the general formula: wherein A, R2, R3, R4, R5, R6 and n are as defined in the specification, exhibit an AP-1 activity inhibitory action and, based on the AP-1 inhibitory action, suppresses the expression of a wide variety of genes and are useful as an agent for treating and preventing autoimmune diseases with lessoned side reactions.
    Type: Grant
    Filed: November 8, 2000
    Date of Patent: May 7, 2002
    Assignee: Toyama Chemical Co., Ltd.
    Inventors: Hisaaki Chaki, Yukihiko Aikawa, Mikako Miyajima, Morihiro Nishio, Hiroshi Kuroda, Keiichi Tanaka, Shuichi Hirono, Shunichi Shiozawa
  • Patent number: 6070127
    Abstract: A method of superposing molecular conformations of a plurality of compounds containing a plurality of characteristic groups is provided involving the steps of:(1) dividing the plurality of characteristic groups into four types selected from hydrophobicity, hydrogen-bonding donor, hydrogen-bonding acceptor and hydrogen-bonding donor/acceptor;(2) fixing a molecule of a first compound from the plurality of compounds having a largest molecular volume and translating, rotating or both a center of mass of each of the remaining compounds of the plurality of compounds to superpose the remaining compounds with the first compound to provide a superposed group of compounds, such that characteristic groups of the same type are overlapped;(3) assigning a score to combinations of characteristic groups present in the superposed group of compounds;(4) summing scores from (3) for the superposed group of compounds to provide a score value for the superposed group of compounds; and(5) repeating steps (1) to (4) until a highest
    Type: Grant
    Filed: October 24, 1997
    Date of Patent: May 30, 2000
    Assignee: Kyorin Pharmaceutical Co., Ltd.
    Inventors: Shuichi Hirono, Kazuhiko Iwase
  • Patent number: 5004805
    Abstract: A hepatocyte growth factor comprising a proteinous substance derived from human blood and showing the following physicochemical properties and physiologic activity:(i) its molecular weight is estimated to be approximately 76,000 to 92,00 by SDS-PAGE analysis (under non-reductive conditon);(ii) it possesses HGF activity;(iii) the HGF activity is inactivated by heat treatment for 10 minutes at 80.degree. C.;(iv) the HGF activity may be lost by digestion with trypsin or with chymotrypsin; and(v) it has a high affinity for heparin.
    Type: Grant
    Filed: June 4, 1987
    Date of Patent: April 2, 1991
    Assignees: Shuji Hashimoto, Yasushi Daikuhara, Eiichi Gohda, Hirohito Tsubouchi, Mitsubishi Kasei Corporation
    Inventors: Eiichi Gohda, Hirohito Tsubouchi, Hiroyuki Nakayama, Shuichi Hirono, Kozo Takahashi, Shuji Hashimoto, Yasushi Daikuhara