Patents by Inventor Shuichi Tsuji

Shuichi Tsuji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sugar chain synthases
    Publication number: 20060057696
    Abstract: The present invention provides O-glycan ?2,8-sialyltransferase which has novel substrate specificity and substrate selectivity, and ?-galactoside ?2,6-sialyltransferase which has novel action and substrate specificity. The sialyltransferase of the present invention can be used as a medicament for suppression of cancer metastasis, prevention of virus infection, suppression of inflammatory response, or activation of neural cells.
    Type: Application
    Filed: January 30, 2003
    Publication date: March 16, 2006
    Inventors: Shou Takashima, Masafumi Tsujimoto, Shuichi Tsuji
  • Sugar-chain synthetase and process for producing the same
    Patent number: 6218161
    Abstract: Novel GalNAc&agr;2,6-sialyltransferases P-B1 and P-B3; GalNAc&agr;2,6-sialyltransferase genes encoding the above GalNAc&agr;2,6-sialyltransferases P-B1 and P-B3; and an extracellularly releasable protein catalyzing GalNAc&agr;2,6-sialic acid transfer which comprises a polypeptide portion as being an active domain of the GalNAc&agr;2,6-sialyltransferase P-B1 or P-B3 together with a signal peptide are provided. Also provided is a process for preparing a sialyltransferases which enables efficient recovery of a sialyltransferase expressed in a large quantity in microorganisms.
    Type: Grant
    Filed: August 28, 1998
    Date of Patent: April 17, 2001
    Assignee: The Institute of Physical and Chemical Research
    Inventors: Shuichi Tsuji, Nobuyuki Kurosawa, Toshiro Hamamoto, Young-Choon Lee, Takashi Nakaoka, Naoya Kojima
  • Sia.alpha. 2,3, Gal.beta. 1, 4Glc NAc.alpha. 2,8-sialyltransferase
    Patent number: 6017743
    Abstract: The present invention provides a nucleotide sequence encoding Sia.alpha.2,3Gal.beta.1,4GlcNAc .alpha.2,8-sialyltransferase and an enzymatically active fragment thereof. The present invention also provides a nucleotide sequence encoding an extracellularly releasable protein capable of catalyzing Sia.alpha.2,3Gal.beta.1,4GlcNAc .alpha.2,8-sialyltransfer which comprises an enzymatically active fragment of the Sia.alpha.2,3Gal.beta.1,4GlcNAc .alpha.2,8-sialyltransferase together with a nucleotide sequence encoding at least one signal peptide. The present invention also provides recombinant vectors comprising nucleotide sequences encoding Sia.alpha.2,3Gal.beta.1,4GlcNAc .alpha.2,8-sialyltransferase. Processes for preparing extracellularly releasable polypeptide fragments of Sia.alpha.2,3Gal.beta.1,4GlcNAc .alpha.2,8-sialyltransferase are provided as well.
    Type: Grant
    Filed: October 24, 1997
    Date of Patent: January 25, 2000
    Assignee: The Institute of Physical and Chemical Research
    Inventors: Shuichi Tsuji, Yukiko Yoshida, Naoya Kojima, Nobuyuki Kurosawa, Toshiro Hamamoto
  • Sugar-chain synthetase and process for producing the same
    Patent number: 5854042
    Abstract: Novel GalNAc .alpha. 2,6-sialyltransferases P-B1 and P-B3; GalNAc .alpha. 2,6-sialyltransferase genes encoding the above GalNAc .alpha. 2,6-sialyltransferases P-B1 and P-B3; and an extracellularly releasable protein catalyzing GalNAc .alpha. 2,6-sialic acid transfer which comprises a polypeptide portion as being an active domain of the GalNAc .alpha. 2,6-sialyltransferase P-B1 or P-B3 together with a signal peptide are provided. Also provided is a process for preparing a sialyltransferases which enables efficient recovery of a sialyltransferase expressed in a large quantity in microorganisms.
    Type: Grant
    Filed: August 19, 1996
    Date of Patent: December 29, 1998
    Assignee: The Institute of Physical and Chemical Research
    Inventors: Shuichi Tsuji, Nobuyuki Kurosawa, Toshiro Hamamoto, Young-Choon Lee, Takashi Nakaoka, Naoya Kojima
  • Sia.alpha. 2,3Gal.beta. 1,4GlcNAc .alpha. 2,8-sialyltransferase
    Patent number: 5798244
    Abstract: The subject invention provides Sia.alpha.2,3 Gal.beta.1,4GlcNAc.alpha.2,8-sialyltransferase and an enzymatically active fragment thereof, and a nucleotide sequence encoding said sialyltransferase. The subject invention also provides an extracellularly releasable protein capable of catalyzing Sia.alpha.2,3Gal.beta.1,4GlcNAc.alpha.2,8-sialyltransfer which comprises the enzymatically active fragment of the Sia.alpha.2,3Gal.beta.1,4GlcNAc.alpha.2,8-sialyltransferase together with a signal peptide.
    Type: Grant
    Filed: April 3, 1996
    Date of Patent: August 25, 1998
    Assignee: The Institute of Physical and Chemical Research
    Inventors: Shuichi Tsuji, Yukiko Yoshida, Naoya Kojima, Nobuyuki Kurosawa, Toshiro Hamamoto