Patents by Inventor Shuji Hinuma
Shuji Hinuma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20030138817Abstract: DNA primers effective in screening G protein coupled receptor protein-encoding DNA fragments are provided. The primers which are complementary to nucleotide sequences that are in community with (homologous to) the nucleotide sequences encoding amino acid sequences corresponding to or near the first membrane-spanning domain or the sixth membrane-spanning domain each of known various G protein coupled receptor proteins were designed and synthesized. Methods of amplifying G protein coupled receptor protein-encoding DNAs using the above DNA primers, and novel target G protein coupled receptor protein-encoding DNAs are also provided. Screening of DNA libraries can be efficiently carried out. Human pituitary gland or amygdala-derived and mouse pancreas-derived G protein coupled receptor proteins, etc.Type: ApplicationFiled: October 22, 2002Publication date: July 24, 2003Applicant: Takeda Chemical Industries, Ltd.Inventors: Shuji Hinuma, Yasuaki Ito, Ryo Fujii
-
Publication number: 20030118586Abstract: Rabbit gastropyrolic part smooth muscle-derived G protein coupled receptor proteins, partial peptides thereof; and DNAs containing said protein or partial peptide-encoding DNA are provided. The receptor protein and the DNA coding for said protein can be used for {circle over (1)} determination of ligands; {circle over (2)} acquisition of antibody and antiserum; {circle over (3)} construction of expression system for of a recombinant type receptor protein; {circle over (4)} development of the receptor binding assay system using said expression system and screening of the candidate compounds for pharmaceuticals; {circle over (5)} conducting a drug design based upon a comparison with structurally analogous ligands and receptors; {circle over (6)} preparation of probes and PCR primers for a gene diagnosis; {circle over (7)} preparation of transgenic animals; and {circle over (8)} preparation of model patient animals deficient in the receptor protein DNA.Type: ApplicationFiled: June 28, 2002Publication date: June 26, 2003Inventors: Shuji Hinuma, Ryo Fujii, Yuji Kawamata
-
Publication number: 20030113909Abstract: Rabbit gastropyrolic part smooth muscle-derived G protein coupled receptor proteins, partial peptides thereof; and DNAs containing said protein or partial peptide-encoding DNA are provided. The receptor protein and the DNA coding for said protein can be used for {circle over (1)} determination of ligands; {circle over (2)} acquisition of antibody and antiserum; {circle over (3)} construction of expression system for of a recombinant type receptor protein; {circle over (4)} development of the receptor binding assay system using said expression system and screening of the candidate compounds for pharmaceuticals; {circle over (5)}conducting a drug design based upon a comparison with structurally analogous ligands and receptors; {circle over (6)} preparation of probes and PCR primers for a gene diagnosis; {circle over (7)} preparation of transgenic animals; and {circle over (8)}preparation of model patient animals deficient in the receptor protein DNA.Type: ApplicationFiled: August 14, 2001Publication date: June 19, 2003Applicant: Takeda Chemical Industries, Ltd.Inventors: Shuji Hinuma, Ryo Fujii, Yuji Kawamata
-
Publication number: 20030092618Abstract: This invention relates to a novel polypeptide involving in the modulation of central nervous system function, circulatory function, immune function, gastrointestinal function, metabolic function, reproductive function, etc., it can be used as a drug for treating or preventing a variety of diseases, e.g. HIV infection or AIDS (acquired immune deficiency syndrome) or the like.Type: ApplicationFiled: June 27, 2002Publication date: May 15, 2003Applicant: Takeda Chemical Industries, Ltd.Inventors: Shuji Hinuma, Kazuhiko Tatemoto, Masaki Hosoya, Yugo Habata, Ryo Fujii, Chieko Kitada
-
Publication number: 20030082648Abstract: The present invention provides novel G protein-coupled receptor proteins derived from mouse heart and rat whole brain, which are useful in screening agonists/antagonists, etc., DNAs encoding these proteins, and the like.Type: ApplicationFiled: September 12, 2002Publication date: May 1, 2003Inventors: Shuji Hinuma, Shoji Fukusumi
-
Patent number: 6538107Abstract: DNA primers effective in screening G protein coupled receptor protein-encoding DNA fragments are provided. The primers which are complementary to nucleotide sequences that are in community with (homologous to) the nucleotide sequences encoding amino acid sequences corresponding to or near the first membrane-spanning domain or the sixth membrane-spanning domain each of known various G protein coupled receptor proteins were designed and synthesized. Methods of amplifying G protein coupled receptor protein-encoding DNAs using the above DNA primers, and novel target G protein coupled receptor protein-encoding DNAs are also provided. Screening of DNA libraries can be efficiently carried out. Human pituitary gland or amygdala-derived and mouse pancreas-derived G protein coupled receptor proteins, etc.Type: GrantFiled: December 14, 1999Date of Patent: March 25, 2003Assignee: Takeda Chemical Industries, Ltd.Inventors: Shuji Hinuma, Yasuaki Ito, Ryo Fujii
-
Patent number: 6514988Abstract: A gonadotropin-releasing hormone antagonistic composition, which comprises an optionally substituted condensed-bicyclic compound consisting of a homo or hetero 5 to 7 membered ring and a homo or hetero 5 to 7 membered ring is effective as a propylactic or therapeutic agent for the prevention or treatment of several hormone dependent diseases, for example, a sex hormone dependent cancer (e.g. prostatic cancer, cancer of uterine cervix, breast cancer, pituitary adenoma), benign prostatic hypertrophy, myoma of the uterus, endometriosis, precocious puberty, amenorrhea, premenstrual syndrome, pplycystic ovary syndrome and acne vulgaris; is effective as a fertility controlling agent in both sexes (e.g.Type: GrantFiled: September 29, 2000Date of Patent: February 4, 2003Assignee: Takeda Chemical Industries, Ltd.Inventors: Shuichi Furuya, Nobuo Choh, Koichi Kato, Shuji Hinuma
-
Publication number: 20030008329Abstract: Galanin receptor proteins, production and use thereof including screening of galanin receptor agonists and antagonists are provided. Galanin receptor proteins, etc. or salts thereof, partial peptides thereof, DNAs coding for the above galanin receptor protein, processes for producing the above receptor protein, methods of screening for a galanin receptor agonist and/or antagonist or screening kits therefor, agonist and/or antagonist compounds or salts thereof obtained by the above screening method or the screening kit, pharmaceutical compositions containing the above compound or its salt, and antibodies against the above receptor protein are provided. It is allowable to efficiently screen a galanin receptor agonist or antagonist by using the galanin receptor protein, the partial peptide thereof, the galanin receptor protein-encoding DNA, the receptor protein-containing cell or its membrane fraction.Type: ApplicationFiled: March 4, 2002Publication date: January 9, 2003Applicant: Takeda Chemical Industries, Ltd.Inventors: Shuji Hinuma, Ryo Fujii, Shoji Fukusumi, Tetsuya Ohtaki, Masaki Hosoya, Kazuhiro Ohgi, Haruo Onda
-
Patent number: 6492324Abstract: This invention relates to a novel polypeptide involving in the modulation of central nervous system function, circulatory function, immune function, gastrointestinal function, metabolic function, reproductive function, etc., it can be used as a drug for treating or preventing a variety of diseases, e.g. HIV infection or AIDS (acquired immune deficiency syndrome) or the like.Type: GrantFiled: February 22, 1999Date of Patent: December 10, 2002Assignee: Takeda Chemical Industries, Ltd.Inventors: Shuji Hinuma, Kazuhiko Tatemoto, Masaki Hosoya, Yugo Habata, Ryo Fujii, Chieko Kitada
-
Publication number: 20020168720Abstract: This invention relates to a human amygdaloid nucleus-derived G protein coupled receptor protein or a salt thereof, a partial peptide of the G protein coupled receptor protein, DNA encoding the G protein coupled receptor protein, a method of producing the G protein coupled receptor protein, a method of identifying a ligand to the G protein coupled receptor protein, a method or kit for screening out compounds capable of changing the binding activity of a ligand to the G protein coupled receptor protein, a compound or a salt thereof obtained by the screening method or by using the screening kit, a pharmaceutical composition comprising the compound or a salt thereof, and an antibody against the G protein coupled receptor protein or a partial peptide.Type: ApplicationFiled: February 4, 2002Publication date: November 14, 2002Applicant: Takeda Chemical Industries Ltd.Inventors: Shuji Hinuma, Junichi Sakamoto, Masaki Hosoya
-
Publication number: 20020143152Abstract: The present invention relates to the murine- derived ligand polypeptide for the G protein-coupled receptor proteins.Type: ApplicationFiled: January 10, 2002Publication date: October 3, 2002Inventors: Shuji Hinuma, Shoji Fukusumi
-
Patent number: 6399325Abstract: Galanin receptor proteins, production and use thereof including screening of galanin receptor agonists and antagonists are provided. Galanin receptor proteins, etc. or salts thereof, partial peptides thereof, DNAs coding for the above galanin receptor protein, processes for producing the above receptor protein, methods of screening for a galanin receptor agonist and/or antagonist or screening kits therefor, agonist and/or antagonist compounds or salts thereof obtained by the above screening method or the screening kit, pharmaceutical compositions containing the above compound or its salt, and antibodies against the above receptor protein are provided. It is allowable to efficiently screen a galanin receptor agonist or antagonist by using the galanin receptor protein, the partial peptide thereof, the galanin receptor protein-encoding DNA, the receptor protein-containing cell or its membrane fraction.Type: GrantFiled: October 11, 1995Date of Patent: June 4, 2002Assignee: Takeda Chemical Industries, Ltd.Inventors: Shuji Hinuma, Ryo Fujii, Shoji Fukusumi, Tetsuya Ohtaki, Masaki Hosoya, Kazuhiro Ohgi, Haruo Onda
-
Publication number: 20020009771Abstract: This invention relates to a human amygdaloid nucleus-derived G protein coupled receptor protein or a salt thereof, a partial peptide of the G protein coupled receptor protein, DNA encoding the G protein coupled receptor protein, a method of producing the G protein coupled receptor protein, a method of identifying a ligand to the G protein coupled receptor protein, a method or kit for screening out compounds capable of changing the binding activity of a ligand to the G protein coupled receptor protein, a compound or a salt thereof obtained by the screening method or by using the screening kit, a pharmaceutical composition comprising the compound or a salt thereof, and an antibody against the G protein coupled receptor protein or a partial peptide.Type: ApplicationFiled: February 6, 1997Publication date: January 24, 2002Inventors: SHUJI HINUMA, JUNICHI SAKAMOTO, MASAKI HOSOYA
-
Patent number: 6228984Abstract: The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervous system function modulators, and pancreatic function modulators, and (2) development of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.Type: GrantFiled: February 7, 1997Date of Patent: May 8, 2001Assignee: Takeda Chemical Industries, Ltd.Inventors: Shuji Hinuma, Yugo Habata, Yuji Kawamata, Masaki Hosoya, Ryo Fujii, Shoji Fukusumi, Chieko Kitada
-
Patent number: 6187788Abstract: A gonadotropin-releasing hormone antagonistic composition, which comprises an optionally substituted condensed-bicyclic compound consisting of a homo or hetero 5 to 7 membered ring and a homo or hetero 5 to 7 membered ring is effective as a propylactic or therapeutic agent for the prevention or treatment of several hormone dependent diseases, for example, a sex hormone dependent cancer (e.g. prostatic cancer, cancer of uterine cervix, breast cancer, pituitary adenoma), benign prostatic hypertrophy, myoma of the uterus, endometriosis, precocious puberty, amenorrhea, premenstrual syndrome, polycystic ovary syndrome and acne vulgaris; is effective as a fertility controlling agent in both sexes (e.g.Type: GrantFiled: October 1, 1998Date of Patent: February 13, 2001Assignee: Takeda Chemical Industries, Ltd.Inventors: Shuichi Furuya, Nobuo Choh, Koichi Kato, Shuji Hinuma
-
Patent number: 6180792Abstract: The thienopyrimidine derivatives of the present invention are described in the following formula: The thienopyrimidine derivatives of the present invention are useful for treating mammals suffering from disorders related to gonadotropin realeasing hormone (GnRH).Type: GrantFiled: January 12, 2000Date of Patent: January 30, 2001Assignee: Takeda Chemical Industries, Ltd.Inventors: Shuichi Furuya, Nobuo Choh, Koichi Kato, Shuji Hinuma
-
Patent number: 6117645Abstract: Disclosed are CHO cells which are capable of continued production of human LH-RH receptor proteins, or cell membrane fractions thereof; recombinant human LH-RH receptor proteins or partial peptides thereof; methods for screening compounds which have affinity for an LH-RH receptor by contacting the compound with the CHO cells or the cell membrane fractions thereof, or the recombinant human LH-RH receptor proteins or the partial peptides thereof; kits for screening them; the compounds which have affinity for the LH-RH receptor obtained by methods for the screening or kits for the screening; and pharmaceutical compositions containing the compound, thereby being able to early provide prophylactic or therapeutic compositions, for example, for prostate cancer, uterine cancer, breast cancer, a pituitary tumor, endometriosis, hysteromyoma or precocious puberty. They are also useful as a pregnancy controlling composition such as contraceptive or a menstrual cycle controlling composition.Type: GrantFiled: June 2, 1997Date of Patent: September 12, 2000Assignee: Takeda Chemical Industries, Ltd.Inventors: Haruo Onda, Shoichi Ohkubo, Shuji Hinuma
-
Patent number: 6114139Abstract: DNA primers effective in screening G protein coupled receptor protein-encoding DNA fragments are provided. The primers which are complementary to nucleotide sequences that are in community with (homologous to) the nucleotide sequences encoding amino acid sequences corresponding to or near the first membrane-spanning domain or the sixth membrane-spanning domain each of known various G protein coupled receptor proteins were designed and synthesized. Methods of amplifying G protein coupled receptor protein-encoding DNAs using the above DNA primers, and novel target G protein coupled receptor protein-encoding DNAs are also provided. Screening of DNA libraries can be efficiently carried out. Human pituitary gland or amygdala-derived and mouse pancreas-derived G protein coupled receptor proteins, etc.Type: GrantFiled: September 14, 1995Date of Patent: September 5, 2000Assignee: Takeda Chemical Industries, Ltd.Inventors: Shuji Hinuma, Masaki Hosoya, Ryo Fujii, Tetsuya Ohtaki, Shoji Fukusumi, Kazuhiro Ohgi
-
Patent number: 6111076Abstract: Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.Type: GrantFiled: September 30, 1998Date of Patent: August 29, 2000Assignee: Takeda Chemical Industries, Ltd.Inventors: Shoji Fukusumi, Shuji Hinuma, Ryo Fujii
-
Patent number: 6048711Abstract: A novel G-protein coupled receptor protein, a partial peptide and their salts are disclosed. DNA encoding the receptor protein, production of the receptor protein, determination of a ligand to the receptor protein, a method for screening for compounds which inhibit ligand binding to the receptor protein, a kit for screening for such compounds are also disclosed. The receptor protein, its partial peptide and their salts are used for screening for candidate compounds of drugs and the like.Type: GrantFiled: October 28, 1997Date of Patent: April 11, 2000Assignee: Takeda Chemical Industries, Ltd.Inventors: Shuji Hinuma, Shoji Fukusumi, Yuji Kawamata